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公开(公告)号：US09346850B2
公开(公告)日：2016-05-24
申请号：US14204074
申请日：2014-03-11
Applicant: KANEKA CORPORATION
Inventor： Hiroshi Murao , Ken-ichiro Morio , Masaru Mitsuda
CPC classification number: C07K1/061 , C07K1/02 , C07K1/14 , C07K5/06078 , C07K5/06095 , C07K5/0806 , C07K5/0808 , C07K5/101
Abstract: The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active ester of an acid component is decreased to 1% or less in a liquid phase peptide synthesis method. According to the invention, a target peptide of high purity can be simply and efficiently produced by a continuous liquid phase synthesis method. Further, the present invention is related to a method of producing a peptide, characterized in using an amide-type solvent immiscible with water in a liquid phase peptide synthesis method. According to the invention, various peptides can be produced by the liquid phase synthesis method without being restricted by the amino acid sequence of the target peptide.
Abstract translation: 本发明涉及一种生产肽的方法，其特征在于在缩合反应之后将反应混合物与碱反应以在碱性条件保持下进行水解，直到酸组分的剩余未反应的活性酯的比例降低至 在液相肽合成方法中为1％以下。 根据本发明，可以通过连续液相合成法简单有效地制备高纯度的靶肽。 此外，本发明涉及一种制备肽的方法，其特征在于在液相肽合成方法中使用与水不混溶的酰胺型溶剂。 根据本发明，可以通过液相合成法制备各种肽，而不受目标肽的氨基酸序列的限制。
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公开(公告)号：US10189007B2
公开(公告)日：2019-01-29
申请号：US15029551
申请日：2014-10-14
Applicant: KANEKA CORPORATION
Inventor： Asuka Hayashi , Yoshikazu Kawai , Ken-ichiro Morio
IPC: B01J20/24 , C07K17/12 , B01J20/285 , B01J20/30 , B01J20/32 , B01J20/286 , C08J9/28 , C08B15/10 , C08J9/16 , C07K1/14 , C07K1/22
Abstract: The objective of the present invention is to provide a method for easily and efficiently producing cellulose beads which have pore shape suitable for an adsorbent and of which adsorption performance is excellent without using highly toxic and highly corrosive auxiliary raw material and without industrially disadvantageous cumbersome step. The method for producing porous cellulose beads according to the present invention is characterized in comprising (a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a crosslinking agent to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.
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公开(公告)号：US10040053B2
公开(公告)日：2018-08-07
申请号：US15029293
申请日：2014-10-14
Applicant: KANEKA CORPORATION
Inventor： Kento Kanaya , Yoshikazu Kawai , Takahiro Okubo , Ken-ichiro Morio
IPC: B01J20/24 , B01J20/285 , B01D15/00 , B01J20/32 , C02F1/28 , C12P19/14 , B01J20/26 , B01J20/30 , B01J20/28 , C08J9/00 , B01J20/00 , B01J39/00 , C02F1/42 , C02F1/52 , B01D21/01 , C07K1/22 , C08J9/26 , G01N30/52 , B01J20/286
Abstract: The objective of the present invention is to provide to a method for easily producing high-performance porous cellulose beads having high mechanical strength. Also, the objective of the present invention is to provide an adsorbent produced from the high-performance porous cellulose beads. According to the present invention, high-performance porous cellulose beads can be easily produced from porous cellulose beads, and an adsorbent having high strength and high adsorption amount can be easily produced from the high-performance porous cellulose beads.
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