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公开(公告)号：US20220347450A1
公开(公告)日：2022-11-03
申请号：US17862315
申请日：2022-07-11
Inventor： Jungkwun KIM , Keun Ho LEE , Jung Dong KIM , Dohyeon JEONG
Abstract: Lithography fabrication methods for producing polymeric microneedles, microprobes, and other micron-sized structures with sharp tips. The fabrication process utilizes a single-step bottom-up exposure of photosensitive resin through a photomask micro-pattern, with a corresponding change/increase in refractive index of the resin creating a meta-state waveguide within the resin which focuses down additional transmitted energy and forms a converging shape (first harmonic microcone). Energy is diffracted through the tip of the first harmonic microcone as a second harmonic beam to form a second converging shape (second harmonic shape) adjacent the first microcone, followed by additional tertiary harmonic microcones, which can be built upon these structures with application of additional energy.
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公开(公告)号：US20220104748A1
公开(公告)日：2022-04-07
申请号：US17552954
申请日：2021-12-16
Applicant: RAPHAS CO., LTD.
Inventor： Keun Ho LEE , Eun Jin AN , Jung Hyun BAE , Jung Dong KIM , Do Hyeon JEONG
Abstract: The present disclosure relates to a microneedle array for bio-sensing or a biosensor using the microneedle array. The microneedle array for bio-sensing does not include an additional electrode or an additional conductive coating, have a solid structure, and is homogeneous throughout the solid structure. The microneedle array for bio-sensing is composed of a material including poly (3,4-ethylendeddioxythiophene):poly (styrenesulfonate) (PEDOT:PSS).
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公开(公告)号：US20210345996A1
公开(公告)日：2021-11-11
申请号：US17380258
申请日：2021-07-20
Applicant: RAPHAS CO., LTD.
Inventor： Keun Ho LEE , Eun Jin AN , Seong Jin KIM , Chang Yub SUNG , Jung Dong KIM , Do Hyeon JEONG , Kwang Hoon LEE
Abstract: The present disclosure relates to a minimally-invasive skin biopsy method. The minimally-invasive skin biopsy method according to the present disclosure includes: preparing a microneedle patch; attaching the microneedle patch to a skin of an object; maintaining a state in which the microneedle patch is attached to the skin of the object for a predetermined period of time; and detaching the microneedle patch from the skin of the object after the predetermined period of time, and analyzing a protein component of the object, which adheres to a microneedle of the microneedle patch. The microneedle is made of a biocompatible polymer substance.
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公开(公告)号：US20230148950A1
公开(公告)日：2023-05-18
申请号：US17995559
申请日：2020-06-11
Applicant: RAPHAS CO., LTD.
Inventor： Do Hyeon JEONG , Jung Dong KIM , Keun Ho LEE , Kwang Hoon LEE
IPC: A61B5/00 , G01N33/68 , G01N33/573 , A61B10/02
CPC classification number: A61B5/445 , A61B5/685 , A61B10/02 , G01N33/573 , G01N33/6869 , G01N2333/5406 , G01N2333/5437 , G01N2800/202
Abstract: A minimally-invasive atopic dermatitis test method comprises the steps of: applying, to the skin of a subject, a microneedle patch including a plurality of microneedles made of a biodegradable hyaluronic acid polymer and having a solid core structure and a bottom layer which is a base on which the plurality of microneedles are formed; maintaining the microneedle patch attached to the skin of the subject for a predetermined time; separating the microneedle patch from the skin of the subject after a predetermined time has passed to input the microneedle patch to a quantitative test; reading the amount of interleukin-4 and interleukin-13 adsorbed onto the surface of the microneedles of the microneedle patch in the quantitative test step; and evaluating atopic dermatitis activity on the basis of the reading of the amount of interleukin-4 and interleukin-13.
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