公开(公告)号：US20170283453A1

公开(公告)日：2017-10-05

申请号：US15507628

申请日：2015-08-31

Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN

Inventor： Robert NEELY ,  Volker LEEN ,  Johan HOFKENS

IPC: C07H19/16 ,  C12Q1/68 ,  C12N9/10

CPC classification number: C07H19/16 ,  C07H19/167 ,  C12N9/1007 ,  C12Q1/6876 ,  C12Q2600/154 ,  C12Y201/01072

Abstract: Cofactor analogues for methyltransferases are disclosed. The compounds are represented by formula (I) wherein R1 is COOH or COO—; X is an organic or inorganic anion carrying one or more negative charges; Y and Y′ are H, or an alkyl; R2 is NH2, NHBoc, or H; and Z is S or Se. R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond, an aromatic carbocyclic or heterocyclic system in β-position to the sulfonium center, unsaturated c-c bond, or c-heteroatom bond where the heteroatom is O, N, S.