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1.发明申请Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles 审中-公开遗传因素，蛋白质和相关方法，包括向克（+）热嗜酸粒细胞应用额外的遗传信息公开(公告)号：US20110275135A1
公开(公告)日：2011-11-10
申请号：US12800045
申请日：2010-05-05
Applicant: Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
IPC: C12N9/02 , C12N9/14 , C12N9/00 , C12N9/90 , C07K14/195 , C12N9/16 , C12N9/10 , C12N9/12 , C07H21/00 , C12N9/52
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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公开(公告)号：US20140273236A1
公开(公告)日：2014-09-18
申请号：US14209634
申请日：2014-03-13
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
IPC: C12N15/87
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
Abstract translation: 本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。
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3.发明申请TYPE II RESTRICTION MODIFICATION SYSTEM METHYLATION SUBUNIT OF ALICYCLOBACILLUS ACIDOCALDARIUS 有权乙型胆碱酯酶II型限制性修饰体系甲基化亚型公开(公告)号：US20140093936A1
公开(公告)日：2014-04-03
申请号：US14055966
申请日：2013-10-17
Applicant: BATTELLE ENERGY ALLIANCE, LLC
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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公开(公告)号：US09045758B2
公开(公告)日：2015-06-02
申请号：US14209634
申请日：2014-03-13
Applicant: Coskata, Inc.
Inventor： Andrew Reeves
CPC classification number: C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
Abstract: This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
Abstract translation: 本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。
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5.发明授权公开(公告)号：US08569030B2
公开(公告)日：2013-10-29
申请号：US13604979
申请日：2012-09-06
Applicant: Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
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Patent Agency Ranking
公开(公告)号：US20090186816A1
公开(公告)日：2009-07-23
申请号：US12143886
申请日：2008-06-23
Applicant: Michal Minczuk , Monika A. Papworth , Aaron Klug
Inventor： Michal Minczuk , Monika A. Papworth , Aaron Klug
IPC: A61K38/00 , C12N15/63 , C07H21/04 , C07K14/00 , C12N9/14 , A61K31/7088 , C12N5/00 , C12P21/06 , C12N15/00
CPC classification number: A61K38/1709 , A61K38/45 , A61K38/46 , C07K14/47 , C07K2319/07 , C07K2319/095 , C07K2319/81 , C12N9/1007 , C12N9/14 , C12Y201/01072 , C12Y306/03014
Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
Abstract translation: 提供了将线粒体蛋白递送至线粒体的方法。 还提供了包含编码与线粒体靶向序列（MTS）和核出口信号（NES）融合的DNA结合多肽的编码序列的核酸构建体，以及编码的蛋白质。 该构建体成功地将DNA结合蛋白递送至线粒体。 基于上述构建体的嵌合甲基化酶被成功地递送至线粒体，导致mtDNA的修饰。
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公开(公告)号：US20170283453A1
公开(公告)日：2017-10-05
申请号：US15507628
申请日：2015-08-31
Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN
Inventor： Robert NEELY , Volker LEEN , Johan HOFKENS
CPC classification number: C07H19/16 , C07H19/167 , C12N9/1007 , C12Q1/6876 , C12Q2600/154 , C12Y201/01072
Abstract: Cofactor analogues for methyltransferases are disclosed. The compounds are represented by formula (I) wherein R1 is COOH or COO—; X is an organic or inorganic anion carrying one or more negative charges; Y and Y′ are H, or an alkyl; R2 is NH2, NHBoc, or H; and Z is S or Se. R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond, an aromatic carbocyclic or heterocyclic system in β-position to the sulfonium center, unsaturated c-c bond, or c-heteroatom bond where the heteroatom is O, N, S.
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公开(公告)号：US20170223914A1
公开(公告)日：2017-08-10
申请号：US15419700
申请日：2017-01-30
Applicant: Michael E Fromm
Inventor： Michael E Fromm
CPC classification number: A01H1/02 , A01G7/00 , A01H3/00 , C12Y201/01072 , C12Y306/03
Abstract: Methods for using seeds comprising an epigenetic trait for reproducibly producing seed lots for sale with similar agronomic performance over multiple years and production cycles are provided.
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9.发明申请公开(公告)号：US20170107524A1
公开(公告)日：2017-04-20
申请号：US15395184
申请日：2016-12-30
Applicant: Battelle Energy Alliance, LLC
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
IPC: C12N15/74 , C07K14/195
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
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10.发明授权Type II restriction-modification system methylation subunit of Alicyclobacillus acidocaldarius 有权II型限制性修饰系统酸性脂环酸杆菌的甲基化亚基公开(公告)号：US09029114B2
公开(公告)日：2015-05-12
申请号：US14055966
申请日：2013-10-17
Applicant: Battelle Energy Alliance, LLC
Inventor： Brady D. Lee , Deborah T. Newby , Jeffrey A. Lacey , David N. Thompson , Vicki S. Thompson , William A. Apel , Francisco F. Roberto , David W. Reed
CPC classification number: C12N15/74 , C07K14/195 , C12N9/00 , C12N9/1007 , C12N9/52 , C12N15/87 , C12Y201/01072
Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.
Abstract translation: 提供了分离和/或纯化的多肽和编码来自酸热环酸杆菌的多肽的核酸序列。 进一步提供的是使用分离和/或纯化的多肽和/或酸碱热杆菌的核酸序列调节或改变细胞内部或外部的重组的方法。
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