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公开(公告)号：US20150119353A1
公开(公告)日：2015-04-30
申请号：US14380633
申请日：2013-02-21
Applicant: KCI Licensing, Inc.
Inventor： Neal Vail
IPC: A61K31/738 , A01N57/12 , A61K31/69 , A61K31/702 , A61K31/661 , A01N43/16 , A01N55/08
CPC classification number: A61K31/738 , A01N43/16 , A01N55/08 , A01N57/12 , A61K31/661 , A61K31/69 , A61K31/702 , A61K31/715 , A61K31/722 , A61K31/80 , A61K45/06 , A61K47/32 , A61K47/34 , A61L24/0015 , A61L24/08 , A61L2300/404 , A61P17/02 , A61K2300/00 , C08L5/08
Abstract: The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions, In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, the ability to promote cell attachment, biocompatiblility, and/or biodegradability. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.
Abstract translation: 本发明提供了包含聚阳离子和聚阳离子的新组合物，以及这些新组合物的制备和使用。一方面，新组合物是复合凝聚剂。 本文所述的组合物可以具有几种所需的性质，包括在水中的低界面张力，可调节的内聚强度，抗微生物活性，在生理pH附近或附近溶解的适合性，促进细胞附着的能力，生物相容性和/或生物降解性。 因此，在各种实施方案中，复合凝聚层可用于例如在体内的水基应用。
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Patent Agency Ranking
公开(公告)号：US20150038400A1
公开(公告)日：2015-02-05
申请号：US14458446
申请日：2014-08-13
Applicant: KCI Licensing, Inc.
Inventor： Neal Vail
Abstract: The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions. In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, biocompatiblility, and/or biodegradability. The compositions can have the ability of promoting cell attachment, cell adhesion, cell migration, cell differentiation, and/or morphogenesis. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.
Abstract translation: 本教导提供了包含聚阳离子和聚阳离子的新组合物，以及这些新组合物的制备和用途。 一方面，新组合物是复合凝聚剂。 本文所述的组合物可以具有几种所需的性质，包括在水中的低界面张力，可调节的内聚强度，抗微生物活性，在生理pH附近或附近溶解的适合性，生物相容性和/或生物降解性。 组合物可以具有促进细胞附着，细胞粘附，细胞迁移，细胞分化和/或形态发生的能力。 因此，在各种实施方案中，复合凝聚层可用于例如在体内的水基应用。
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公开(公告)号：US20160108144A1
公开(公告)日：2016-04-21
申请号：US14766191
申请日：2014-01-14
Applicant: KCI LICENSING, INC.
Inventor： Neal Vail
CPC classification number: C08F28/02 , A61L24/0015 , A61L24/043 , C08G83/00
Abstract: The present teachings provide novel polymers, and methods of preparing and using thereof. The novel polymers each includes a sulfide, sulfonyl, or sulfonyl bond. The novel polymer are used to make polycations and/or polyanions, which can be used, for example, to produce adhesive complex coacervates.
Abstract translation: 本教导提供新型聚合物及其制备和使用方法。 新型聚合物各自包括硫化物，磺酰基或磺酰基键。 新型聚合物用于制备聚阳离子和/或聚阴离子，其可用于例如生产粘合剂复合凝聚层。
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公开(公告)号：US20130273145A1
公开(公告)日：2013-10-17
申请号：US13786067
申请日：2013-03-05
Applicant: KCI Licensing, Inc.
Inventor： Neal Vail
Abstract: The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions. In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, biocompatiblility, and/or biodegradability. The compositions can have the ability of promoting cell attachment, cell adhesion, cell migration, cell differentiation, and/or morphogenesis. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.
Abstract translation: 本教导提供了包含聚阳离子和聚阳离子的新组合物，以及这些新组合物的制备和用途。 一方面，新组合物是复合凝聚剂。 本文所述的组合物可以具有几种所需的性质，包括在水中的低界面张力，可调节的内聚强度，抗微生物活性，在生理pH附近或附近溶解的适合性，生物相容性和/或生物降解性。 组合物可以具有促进细胞附着，细胞粘附，细胞迁移，细胞分化和/或形态发生的能力。 因此，在各种实施方案中，复合凝聚层可用于例如在体内的水基应用。
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公开(公告)号：US10077324B2
公开(公告)日：2018-09-18
申请号：US14766191
申请日：2014-01-14
Applicant: KCI Licensing, Inc.
Inventor： Neal Vail
CPC classification number: C08F28/02 , A61L24/0015 , A61L24/043 , C08G83/00
Abstract: The present teachings provide novel polymers, and methods of preparing and using thereof. The novel polymers each includes a sulfide, sulfonyl, or sulfonyl bond. The novel polymer are used to make polycations and/or polyanions, which can be used, for example, to produce adhesive complex coacervates.
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公开(公告)号：US10004645B2
公开(公告)日：2018-06-26
申请号：US14489208
申请日：2014-09-17
Applicant: KCI Licensing, Inc.
Inventor： Dmitry Zimnitsky , Neal Vail
CPC classification number: A61F13/02 , A61B90/39 , A61B2090/3966 , A61F13/00068 , A61F13/0216 , A61F13/0226 , A61F13/0276 , A61F2013/00536 , A61M1/0088 , A61M2205/32
Abstract: A method of manufacturing a manifold pad that is, at least in part, radiopaque includes providing a manifold member having a plurality of flow channels; providing a radioopacifier; and heating the manifold member and the radioopacifier in a heating vessel at an elevated temperature to form the manifold pad. The manifold pad may distribute reduced pressure at a tissue site and allow for detection using radiography. Systems, manifold pads, and other methods are also presented.
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