公开(公告)号：US20230166056A1

公开(公告)日：2023-06-01

申请号：US17921777

申请日：2021-04-26

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Peter D. Hodson ,  Adam J. Stuart

IPC: A61M15/00 ,  B65D55/16

CPC classification number: A61M15/0025 ,  A61M15/009 ,  B65D55/16

Abstract: An actuator (100) for an inhaler includes a sleeve (106) having a first end (102) and a second end (104). The sleeve is substantially hollow and defines a longitudinal axis (110) along its length. A base (108) is formed at the first end of the sleeve. A mouthpiece (112) is joined to the sleeve and the base. The mouthpiece is substantially hollow and defines a delivery opening (114). The actuator includes a cover (116) removably attached to the mouthpiece for covering the delivery opening. The actuator further includes a retaining member for retaining the cover to the sleeve upon removal of the cover from the mouthpiece. The retaining member includes a ring (120) disposed around the sleeve. The ring is at least selectively rotatable about the longitudinal axis and slidable along the longitudinal axis relative to the sleeve. The retaining member further includes a strap (122) extending from the ring and attached to the cover.

公开(公告)号：US11207477B2

公开(公告)日：2021-12-28

申请号：US16613578

申请日：2018-05-15

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Peter D. Hodson

IPC: A61M15/00 ,  A61K9/12 ,  A61K31/137 ,  A61K31/46 ,  A61K47/06 ,  A61K47/34

Abstract: Formulations containing pharmaceutical active agent, propellant, and water at least partially adsorbed on or absorbed within one or more nylon pellets or nylon components of, for example, an inhaler such as a metered dose inhaler. Canisters, typically sealed canisters, containing such formulations. Inhalers, such as metered dose inhalers, containing such canisters. Methods of making and using the same.

公开(公告)号：US11376378B2

公开(公告)日：2022-07-05

申请号：US16064367

申请日：2016-12-21

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Romain U. G. Guion ,  Christopher G. Blatchford ,  David J. Cottenden ,  Iain G. McDerment ,  Christopher B. J. Groombridge ,  Peter D. Hodson ,  John P. Bunting ,  Adam J. Stuart ,  Simon L. Calcutt ,  Stephanie Willis ,  Stephen Pitson

IPC: A61M15/00 ,  A61M16/00

Abstract: A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

公开(公告)号：US11273272B2

公开(公告)日：2022-03-15

申请号：US16331227

申请日：2017-09-05

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Adam J. Stuart ,  Peter D. Hodson

IPC: A61M15/00

Abstract: A breath-responsive inhaler having a trigger mechanism for triggering delivery of a medicament to a user, the trigger mechanism including a medicament source, having a primed position in which the inhaler is primed for use and an actuated position in which the medicament source is actuated to dispense a dose of medicament, a toggle mechanism for selectively permitting movement of the source from its primed position to its actuated position, the toggle mechanism comprising a vane positioned in the air flow path, the vane being pivoted about a vane pivot, and wherein the trigger mechanism is triggered by movement of the vane upon inhalation of the user to move the toggle mechanism between a primed condition in which the medicament source is maintained in its primed position by cooperation with the toggle mechanism and an actuated condition in which the toggle mechanism is disengaged from cooperation with the medicament source.

公开(公告)号：US20210386943A1

公开(公告)日：2021-12-16

申请号：US17419436

申请日：2019-12-27

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Peter D. Hodson ,  Parfes Mohammed ,  Adam J. Stuart ,  Paul H.R. Jolly

IPC: A61M15/00

Abstract: An inhaler having an air inlet, a medicament source, and an outlet for delivering an air and medicament admixture to a user, the inhaler including a primary power supply for powering the controller and a sensor for detecting a recent shake event, wherein, the sensor is independent of the primary power source and, in use, the sensor provides the controller with a signal indicative of any recent shake event upon the powering up of the controller prior to use of the inhaler.

公开(公告)号：US11707584B2

公开(公告)日：2023-07-25

申请号：US16609234

申请日：2018-04-30

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Peter D. Hodson ,  Stephen J. Howgill

IPC: A61M15/00

CPC classification number: A61M15/0093

Abstract: An inhaler (60) has a breath actuated trigger mechanism (100) reactive to an inhalation flow to trigger the release of a substance to be inhaled. The inhaler (60) has an inspiration flow which is subject to a higher degree of flow governing post-triggering than pre-triggering. This allows the triggering flow rate to be closer to, or even higher than, the governing flow rate of the inhaler.

公开(公告)号：US11083855B2

公开(公告)日：2021-08-10

申请号：US16064413

申请日：2016-12-13

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： William T. Richardson ,  John P. Bunting ,  Peter D. Hodson ,  Christopher B. J. Groombridge ,  David J. Cottenden

IPC: A61M15/00 ,  B65D83/38 ,  B65D83/16

Abstract: An auto-reset dose release firing system (101) and a method of using same. The system can include an a stored energy device (109); a first plunger (103) movable between first, second, and third positions, the first plunger configured to be operatively coupled to a medicament canister (51); and a second plunger (104) movable between first and second positions; the first and second plunger being movable with respect to one another and shaped to define an evacuable chamber (185) therebetween. The first plunger and the second plunger can move together from their respective first positions to their respective second positions, due to a reduced pressure in the chamber, to cause a dose release valve (54) to fire. After firing, air can be allowed to move into the chamber to allow the first plunger to move with respect to the second plunger to its third position to allow the dose release valve to reset.

公开(公告)号：US11020548B2

公开(公告)日：2021-06-01

申请号：US16154470

申请日：2018-10-08

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Adam J. Stuart ,  Peter D. Hodson

IPC: A61M15/00 ,  G06M1/04 ,  G06M1/08

Abstract: The present disclosure relates to a dose indicator for a pressure-actuated metered dose inhaler (pMDI) device. In an embodiment, the dose indicator comprises a chassis element having a viewing portion, a display element located within the chassis element, a resilient deformable element, and an indexing element having an axis, translation of the indexing element along its axis from a first position to a second position causing deformation of the resilient deformable element in the same direction as translation of the indexing element resulting in generally greater displacement of portions of the resilient deformable element nearer to the axis relative to portions thereof further from the axis, the displacement of the portions of the resilient deformable element in the same direction as translation of the indexing element inducing indexing of the display element from a current position to a subsequent position relative to the viewing portion of the chassis element.

公开(公告)号：US20230233777A1

公开(公告)日：2023-07-27

申请号：US17779028

申请日：2020-11-18

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： John P. Bunting ,  Lee M. Hodges ,  Peter D. Hodson ,  Stephen J. Howgill ,  Adam J. Stuart ,  Kerry Ward

IPC: A61M15/00 ,  A61M16/20 ,  A61M16/00

CPC classification number: A61M15/0065 ,  A61M16/201 ,  A61M16/0003 ,  A61M2202/0225

Abstract: Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.

公开(公告)号：US20230057979A1

公开(公告)日：2023-02-23

申请号：US17792834

申请日：2021-01-12

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： John P. Bunting ,  Sarah J. Dexter ,  Peter D. Hodson ,  Alexander D. Slowey

IPC: A61K9/00 ,  A61K31/137 ,  A61K31/56 ,  A61K31/573 ,  A61K45/06 ,  A61K47/02 ,  A61K9/12

Abstract: A pressurized medicinal composition comprising at least 40%, by weight, of liquid carbon dioxide, a fluid that forms a homogeneous solution with liquid carbon dioxide, and at least one active pharmaceutical ingredient dissolved or suspended in the composition. The composition may have a liquid to supercritical transition temperature greater than 40° C. Also, metered dose inhalers comprising an actuator, and a canister equipped with a metering valve, wherein the canister houses a reservoir comprising a pressurized carrier fluid mixture for dissolving or suspending at least one active pharmaceutical ingredient, the carrier fluid mixture comprising liquid carbon dioxide and a second component that is a liquid at room temperature and pressure.