公开(公告)号：US20210133953A1

公开(公告)日：2021-05-06

申请号：US16472439

申请日：2017-12-18

Applicant: Konica Minolta, Inc.

Inventor： Hiroaki KEMMOCHI ,  Yasuyuki MOTOKUI ,  Noboru KOYAMA

IPC: G06T7/00 ,  G01N21/64

Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.

公开(公告)号：US20200371106A1

公开(公告)日：2020-11-26

申请号：US16491768

申请日：2018-03-09

Applicant: Konica Minolta, Inc.

Inventor： Masaru TAKAHASHI ,  Yasuyuki MOTOKUI ,  Noboru KOYAMA

IPC: G01N33/574 ,  A61B5/00 ,  C12Q1/6804

Abstract: Disclosed herein is a method including: acquiring one or more pieces of information including information about expression status of a specific biomarker in a lesion collected from a human by using a laboratory animal transplanted with the lesion; and using the information to estimate therapeutic efficacy through analysis

公开(公告)号：US20200003778A1

公开(公告)日：2020-01-02

申请号：US16481013

申请日：2018-02-02

Applicant: Konica Minolta, Inc.

Inventor： Masaru TAKAHASHI ,  Takeshi SHIRAISHI ,  Noboru KOYAMA

IPC: G01N33/574 ,  G01N33/58

Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.

公开(公告)号：US20210311024A1

公开(公告)日：2021-10-07

申请号：US15999859

申请日：2017-02-15

Applicant: Konica Minolta, Inc.

Inventor： Hideki GOUDA ,  Takeshi SHIRAISHI ,  Takeshi ISODA ,  Noboru KOYAMA ,  Hisatake OKADA

IPC: G01N33/50 ,  G01N33/574

Abstract: An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.

公开(公告)号：US20210041446A1

公开(公告)日：2021-02-11

申请号：US15999660

申请日：2017-02-15

Applicant: KONICA MINOLTA, INC.

Inventor： Masaru TAKAHASHI ,  Etsuko FUTAYA ,  Hisatake OKADA ,  Noboru KOYAMA

IPC: G01N33/574 ,  C12Q1/6886 ,  G01N21/64

Abstract: The present invention provides a method of obtaining information for the diagnosis or treatment, mainly of cancer or an immune system-related disease, the method including the step of quantifying the expression level of a cancer-associated protein or a nucleic acid in a tumor cell; and/or the step of quantifying the expression level of a protein or a nucleic acid in an immune cell, using a specimen derived from tumor tissue of a human or a non-human.