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    PHOSPHOR-INTEGRATED NANOPARTICLES FOR TARGET SUBSTANCE DETECTION
    1.
    发明申请
    PHOSPHOR-INTEGRATED NANOPARTICLES FOR TARGET SUBSTANCE DETECTION 有权

    公开(公告)号：US20220107306A1

    公开(公告)日：2022-04-07

    申请号：US17423216

    申请日：2019-11-13

    Applicant: Konica Minolta, Inc.

    Inventor： Takeshi ISODA

    IPC: G01N33/533 ,  C12N15/115 ,  G01N33/574

    Abstract: To provide phosphor-integrated nanoparticles for target substance detection, having improved staining performance for labeling and detecting a target protein at high accuracy. The phosphor-integrated nanoparticles for target substance detection are obtained by surface-modifying phosphor-integrated nanoparticles with a surface modification molecule. The surface modification molecule is at least one kind of surface modification molecule selected from the group consisting of a single-chain antibody containing a heavy chain variable region and an aptamer.

    PHOSPHOR-INTEGRATED NANOPARTICLES USED IN FLUORESCENCE OBSERVATION
    3.
    发明申请
    PHOSPHOR-INTEGRATED NANOPARTICLES USED IN FLUORESCENCE OBSERVATION 审中-公开

    公开(公告)号：US20180011086A1

    公开(公告)日：2018-01-11

    申请号：US15544721

    申请日：2015-01-21

    Applicant: Konica Minolta, Inc.

    Inventor： Takeshi ISODA ,  Masaru TAKAHASHI

    IPC: G01N33/533 ,  C09K11/02 ,  G01N33/58 ,  C09K11/08 ,  C08K5/00

    CPC classification number: G01N33/533 ,  C08K5/0025 ,  C09K11/02 ,  C09K11/0805 ,  C09K11/0883 ,  G01N33/48 ,  G01N33/53 ,  G01N33/582

    Abstract: The present invention may provide phosphor-integrated nanoparticles whose precipitation and/or aggregation, particularly aggregation can be inhibited upon carrying out immunostaining therewith and which can thus be used for staining even after long-term storage without requiring a complicated operation, the phosphor-integrated nanoparticles preferrably maintaining excellent performance, such as staining properties, even after long-term storage. The phosphor-integrated nanoparticles of the present invention have an average sphericity (f) of 0.80 to 0.95 and preferably have an average circumference ratio (R) of 0.50 to 0.95. More preferably, the matrix of the particles contains an organic compound, the phosphor-integrated nanoparticles have an average particle size of 300 nm or less, and a biological component-binding molecule is bound on the particle

    METHOD FOR QUANTIFYING BIOLOGICAL MATERIAL BASED ON MULTIPLE IMMUNOSTAINING
    5.
    发明申请
    METHOD FOR QUANTIFYING BIOLOGICAL MATERIAL BASED ON MULTIPLE IMMUNOSTAINING 审中-公开
    基于多种免疫学方法定量生物材料的方法

    公开(公告)号：US20170016911A1

    公开(公告)日：2017-01-19

    申请号：US15124557

    申请日：2015-03-23

    Applicant: Konica Minolta, Inc.

    Inventor： Hideki GOUDA ,  Takeshi ISODA ,  Yasuhiro WATANABE ,  Kohsuke GONDA ,  Noriaki OHUCHI ,  Mika WATANABE

    IPC: G01N33/68 ,  G01N15/14 ,  G01N21/64 ,  G01N1/30 ,  G01N33/58

    CPC classification number: G01N33/6872 ,  G01N1/30 ,  G01N15/1429 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/582 ,  G01N2001/302 ,  G01N2021/6439 ,  G01N2496/80

    Abstract: The present invention provides a method capable of more accurately quantifying a biological material expressed on the cell membrane in pathological samples. The present invention is directed to a method for quantifying a biological material (target biological material) expressed on the cell membrane, the method including the steps of: (1a) immunostaining the target biological material with a fluorescent material; (1b) immunostaining another biological material (reference biological material) on the cell membrane with another fluorescent material; (2) using immunostaining images for the target and reference biological materials to identify the fluorescence signal corresponding to the target biological material and to measure the fluorescence signals corresponding to the target and reference biological materials; and (3) correcting the measured value of the fluorescence signal corresponding to the target biological material by a given method to quantify the expression level.

    Abstract translation: 本发明提供能够更准确地定量病理样品中在细胞膜上表达的生物材料的方法。 本发明涉及一种量化在细胞膜上表达的生物材料（靶生物材料）的方法，所述方法包括以下步骤：（1a）用荧光材料免疫染色目标生物材料; （1b）用另一种荧光材料在细胞膜上免疫染色另一种生物材料（参考生物材料）; （2）使用靶标和参考生物材料的免疫染色图像来鉴定对应于目标生物材料的荧光信号并测量与靶标和参照生物材料相对应的荧光信号; 和（3）通过给定的方法校正与目标生物材料相对应的荧光信号的测量值以量化表达水平。

    STAINING AGENT FOR STAINING TISSUE, PRODUCTION METHOD FOR STAINING AGENT FOR STAINING TISSUE AND TISSUE STAINING KIT INCLUDING STAINING AGENT FOR STAINING TISSUE
    6.
    发明申请
    STAINING AGENT FOR STAINING TISSUE, PRODUCTION METHOD FOR STAINING AGENT FOR STAINING TISSUE AND TISSUE STAINING KIT INCLUDING STAINING AGENT FOR STAINING TISSUE 有权
    用于染色组织的染色剂，用于染色组织的染色剂的生产方法和组织染色试剂盒，包括用于染色组织的染色剂

    公开(公告)号：US20160018300A1

    公开(公告)日：2016-01-21

    申请号：US14773148

    申请日：2014-03-06

    Applicant: KONICA MINOLTA, INC.

    Inventor： Kensaku TAKANASHI ,  Yasushi NAKANO ,  Takeshi ISODA ,  Hideki GOUDA

    IPC: G01N1/30 ,  G01N33/52

    CPC classification number: G01N1/30 ,  G01N33/52 ,  G01N2001/302

    Abstract: An object of the present invention is to provide: a staining agent for tissue staining which has an improved fluorescence signal evaluation accuracy; and a tissue staining kit comprising the staining agent. The staining agent for tissue staining contains, as a staining component, dye-resin particles comprising thermosetting resin particles and a fluorescent dye immobilized on the resin particles, wherein the resin particles contains a substituent having an electric charge opposite to that of the fluorescent dye and forms an ionic bond or a covalent bond with the fluorescent dye, and the dye-resin particles have a particle size variation coefficient of 15% or less.

    Abstract translation: 本发明的目的是提供：具有改善的荧光信号评价精度的组织染色用染色剂; 和包含染色剂的组织染色试剂盒。 用于组织染色的染色剂包含作为染色成分的染料树脂颗粒，其包含固定在树脂颗粒上的热固性树脂颗粒和荧光染料，其中树脂颗粒含有具有与荧光染料相反的电荷的取代基， 与荧光染料形成离子键或共价键，染料树脂粒子的粒径变化系数为15％以下。

    IMMUNOASSAY METHOD LESS AFFECTED BY IMPURITIES
    7.
    发明申请
    IMMUNOASSAY METHOD LESS AFFECTED BY IMPURITIES 有权
    免疫力不受影响的免疫方法

    公开(公告)号：US20150355176A1

    公开(公告)日：2015-12-10

    申请号：US14655998

    申请日：2013-11-15

    Applicant: KONICA MINOLTA, INC.

    Inventor： Takeshi ISODA ,  Tomonori KANEKO

    IPC: G01N33/543 ,  G01N33/574

    CPC classification number: G01N33/54393 ,  G01N21/648 ,  G01N33/50 ,  G01N33/57484 ,  G01N2021/6439 ,  G01N2333/42 ,  G01N2333/4724 ,  G01N2333/96433 ,  G01N2400/00 ,  G01N2400/02

    Abstract: An object of the present invention is to provide a method of measuring the amount of a compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin, which method is suitable for reduction of noise originating from impurities and determination of the exact amount of a target compound.The present invention provides a method of measuring the amount of a target compound containing a sugar chain in a biological sample by a sandwich immunoassay method using a labeled lectin (including cases where a target compound-capturing substance other than an antibody is used as a ligand), the method containing adding a sugar chain compound which competes (crosses) with impurities contained in the biological sample in binding with the labeled lectin.

    Abstract translation: 本发明的目的是提供一种通过使用标记的凝集素的夹心免疫测定法测量生物样品中含有糖链的化合物的量的方法，该方法适用于减少源自杂质的噪声和测定 目标化合物的确切量。 本发明提供了通过使用标记的凝集素的夹心免疫测定法（包括使用除了抗体以外的目标化合物捕获物质作为配体的情况）来测定生物样品中含有糖链的目标化合物的量的方法 ），该方法包含加入与标记的凝集素结合的与生物样品中所含杂质竞争（杂交）的糖链化合物。

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