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公开(公告)号：US20230048408A1
公开(公告)日：2023-02-16
申请号：US17792723
申请日：2021-01-15
发明人： Willem Huijbers , Marco Matters , Rudolf Mathias Johannes Nicolaas Lamerichs , Raymond Van Ee , Adraianus Johannes Maria Denissen , Joanne Henriette Desiree Monique Westerink , Timmy Robertus Maria Leufkens
摘要： The present invention relates to an apparatus for task determination during brain activity analysis. The apparatus comprises an input unit (20), a processing unit (30), and an output unit (40). The input unit is configured to provide the processing unit with measurement data of the brain of a patient performing a task during brain activity analysis. The processing unit is configured to determine a measure of brain activity based on the measurement data of the brain. The processing unit is configured to determine: that the patient should perform a different task to the task they are currently performing and select the different task; or that the patient should continue performing the task that they are currently performing; or that the patient should stop performing the task; The determination comprises utilization of information relating to the task and the determined measure of brain activity and information relating to a plurality of reference tasks and associated plurality of reference measures of brain activity. The output unit is configured to output an indication that the patient should perform the different task, that the patient should continue performing the task, or that the patient should stop performing the task.
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公开(公告)号：US20240277228A1
公开(公告)日：2024-08-22
申请号：US18568299
申请日：2022-06-09
发明人： Raymond Van Ee , Maria Estrella Mena Benito , Joanne Henriette Desiree Monique Westerink , Marieke van Dooren , Timmy Robertus Maria Leufkens , Willem Huijbers , Adrianus Johannes Maria Denissen
IPC分类号： A61B5/00
CPC分类号： A61B5/0036 , A61B5/0042 , A61B5/4848 , A61B5/741 , A61B5/742 , A61B5/7455
摘要： A system and method for controlling rhythmic sensory stimulation provided to a subject with post-stroke depression, PSD, during an MRI scan. A control unit is configured to control a rhythmic sensory stimulation signal such that the signal is rhythmically synchronous to a scanning rhythm of an MRI scanner performing the MRI scan.
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公开(公告)号：US20230404475A1
公开(公告)日：2023-12-21
申请号：US18032203
申请日：2021-10-19
发明人： Raymond Van Ee , Joanne Henriëtte Desirée Monique Westerink , Timmy Robertus Maria Leufkens , Maria Estrella Mena Benito , Adrianus Johannes Maria Denissen , Willem Huijbers
CPC分类号： A61B5/4809 , A61M2021/0083 , A61M21/00 , A61B5/7267
摘要： A system and method for analyzing the brain activity of a subject during a transition between brain states. Brain activity data including data representative of a transition between brain states is received from a brain monitoring system and processed to obtain a value for one or more transition parameters. The one or more transition parameters are parameters that characterize the transition between brain states and may be used as a biomarker for identifying mental disorders.
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公开(公告)号：US20240298955A1
公开(公告)日：2024-09-12
申请号：US18039308
申请日：2021-12-14
发明人： Willem Huijbers , Marieke van Dooren , Raymond Van Ee , Rudolf Mathias Johannes Nicolaas Lamerichs , Timmy Robertus Maria Leufkens , Marco Matters , Joanne Henriëtte Desirée Monique Westerink , Adrianus Johannes Maria Denissen
IPC分类号： A61B5/383
CPC分类号： A61B5/383
摘要： In order to enable more accurate calibration of brain, there is provided a system for creating a hemodynamic brain atlas for calibration of brain hemodynamics. The system comprises a non-invasive transcranial neurostimulation device, a non-invasive neuromonitoring device, and a computing device. The non-invasive transcranial neurostimulation device is configured to induce neuronal activity to evoke a hemodynamic response in a target region of interest (ROI) of a brain of a human subject. The non-invasive neuromonitoring device is configured to monitor the evoked hemodynamic response in the target ROI. The computing device configured to determine a set of parameters representing a hemodynamic response function, HRF, of the evoked hemodynamic response in the target ROI, and to associate the set of parameters of the HRF with the target ROI to form the hemodynamic brain atlas.
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公开(公告)号：US20230375649A1
公开(公告)日：2023-11-23
申请号：US18031031
申请日：2021-10-15
发明人： Maria Estrella Mena Benito , Joanne Henriëtte Desirée Monique Westerink , Raymond Van Ee , Timmy Robertus Maria Leufkens , Marieke Van Dooren , Adrianus Johannes Maria Denissen , Willem Huijbers , Marco Matters
CPC分类号： G01R33/4806 , A61B5/165 , G01R33/5608 , G16H10/20 , G16H30/40
摘要： It is proposed to obtain information about a stress or anxiety level of a subject within a predetermined time period before, during and/or after a capture time of a fMRI scan image. Using this information, embodiments may provide additional/supplementary information that may aid, assist or otherwise improve interpretation of the fMRI scan image.
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公开(公告)号：US20240272257A1
公开(公告)日：2024-08-15
申请号：US18692096
申请日：2022-09-01
发明人： Rudolf Mathias Johannes Nicolaas Lamerichs , Timmy Robertus Maria Leufkens , Joanne Henriëtte Desirée Monique Westerink
IPC分类号： G01R33/48 , A61B5/055 , G01R33/50 , G01R33/565
CPC分类号： G01R33/4806 , A61B5/055 , G01R33/50 , G01R33/56554
摘要： Disclosed herein is a medical system (100, 300) where execution of machine executable instructions (120) causes a computational system (104) to: receive (200) a time series of a R2-star map (122) for a brain volume (500); receive (202) a stimulus signal (124) descriptive of an occurrence of a sensory stimulus; receive (204) a selection of one or more seed voxels (126) identified in the time series of the R2-star map; calculate (206) a denoised time series of the R2-star map (128); calculate (208) a correlation map (130) between the seed voxels and the denoised time series of the R2-star map; determine (210) an activated region (132) of the brain volume using voxels identified in the correlation map; provide (212) a hemodynamic response (134) function for each voxel and each occurrence of the sensory stimulus; and provide (214) a subject specific hemodynamic response function (136) by averaging the hemodynamic response functions.
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公开(公告)号：US20240004470A1
公开(公告)日：2024-01-04
申请号：US18039509
申请日：2021-12-06
发明人： Marieke Van Dooren , Timmy Robertus Maria Leufkens , Raymond Van Ee , Mark Thomas Johnson , Maria Estrella Mena Benito , Willem Huijbers
CPC分类号： G06F3/015 , A61B5/377 , A61B5/055 , A61M21/00 , A61M2021/0016 , A61M2021/0022 , A61M2021/0044 , A61M2021/0066
摘要： Disclosed herein is a medical instrument (100, 300) comprising an activity measurement system (110, 301, 302) configured for measuring brain activity data (136) from a subject (102), a memory (120) storing machine executable instructions (130) and storing a simulation model (132), wherein the simulation model is configured to generating simulation data (134), wherein the simulation model is configured for modifying the simulation data using a model parameter (140), a virtual reality system (106, 106′, 106″, 106′″, 106″″) configured for rendering the simulation data; and a computational system (114) for controlling the medical instrument. Execution of the machine executable instructions causes the computational system to set (200) the model parameter to an initial value (142). Execution of the machine executable instructions further causes the computational system to repeatedly: generate (202) the simulation data using the simulation model; render (204) the simulation data using the virtual reality system; measure (206) the brain activity data using the activity measurement system; calculate (208) a neural activity metric (138) descriptive of neural activity of the subject from the brain activity data; increase (210) the model parameter to adjust the simulation model if the neural activity metric is below a first predetermined value (144); and decrease (212) the model parameter to adjust the simulation model if the neural activity metric is above a second predetermined value (146).
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8.发明公开公开(公告)号：US20240001067A1
公开(公告)日：2024-01-04
申请号：US18036903
申请日：2021-11-23
发明人： Marieke Van Dooren , Timmy Robertus Maria Leufkens , Raymond Van Ee , Rudolf Mathias Johannes Nicolaas Lamerichs , Marco Matters , Maria Estrella Mena Benito , Willem Huijbers , Joanne Henriette Desiree Monique Westerink , Adrianus Johannes Maria Denissen
摘要： The present invention relates to attention bias modification treatment. In order to improve the treatment effect, an ABM system is proposed with a neural brain response monitoring device, such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and/or electroencephalography (EEG), to provide real-time information regarding neural brain responses in order to personalize and optimize the ABM treatment.
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公开(公告)号：US20230255491A1
公开(公告)日：2023-08-17
申请号：US18015979
申请日：2021-07-13
发明人： Maria Estrella Mena benito , Joanne Henriëtte Desirée Monique Westerink , Raymond Van Ee , Timmy Robertus Maria Leufkens
CPC分类号： A61B5/0036 , A61B5/0042 , A61B5/055 , A61B5/163 , A61B5/165 , A61B5/4848 , G01R33/4806 , A61H5/00
摘要： Two subsequent fMRI images taken during or around an EMDR therapy treatment are compared. A change in a trauma level metric in relevant brain anatomy of a traumatized patient is determined and communicated, such that the success of the EMDR therapy can be more objectively assessed and/or the information may be used to tailor the EMDR therapy a during or after a therapy session.
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