公开(公告)号：US20150272444A1

公开(公告)日：2015-10-01

申请号：US14431962

申请日：2013-08-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Konstantin Maslov ,  Todd Nicholas Erpelding ,  Ladislav Jankovic ,  Lihong Wang

IPC: A61B5/00 ,  G06F17/50 ,  G06F17/10 ,  A61B8/00

CPC classification number: A61B5/0095 ,  A61B5/0035 ,  A61B5/7278 ,  A61B8/4416 ,  A61B8/4444 ,  A61B2562/12 ,  F04C2270/041 ,  G01N21/1702 ,  G06F17/10 ,  G06F17/50

Abstract: A photoacoustic medical-imaging device includes a wavelength conversion assembly (108) configured for outputting laser pulses at a targeted wavelength. It also includes a photoacoustic probe configured for acoustic coupling to a patient, for directing the pulses, and for acquiring, in response, radiofrequency data for photoacoustic imaging. It may include an optical fiber bundle (120) that comprises an optical fiber having an input end, and be configured for illuminating, with a homogenous beam, so as to conform to an acceptance angle (160) of the fiber at that end. It may also include a light collimator, and a diffuser for receiving the outputted laser pulses from the collimator. The diffuser may be configured for spreading a focus of the pulsed light (148) over an input aperture of the bundle to equalize the light received by different constituent optical fibers of the bundle. The assembly may include a dye cell (132), and may reside in the probe.

Abstract translation: 光声医学成像装置包括被配置为输出目标波长的激光脉冲的波长转换组件（108）。 它还包括被配置用于与患者的声学耦合的光声探针，用于引导脉冲，并且响应地获取用于光声成像的射频数据。 它可以包括光纤束（120），其包括具有输入端的光纤，并且被配置为用均匀光束照射，以便符合在该端的光纤的接收角（160）。 它还可以包括光准直器和用于从准直器接收输出的激光脉冲的漫射器。 扩散器可以被配置为将脉冲光（148）的焦点扩散在束的输入孔上，以使由束的不同构成光纤接收的光均衡。 组件可以包括染料单元（132），并且可以驻留在探针中。

公开(公告)号：US20140243737A1

公开(公告)日：2014-08-28

申请号：US14349496

申请日：2012-09-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Todd Nicholas Erpelding ,  Ralf Seip ,  Christopher Stephen Hall ,  Balasundar Iyyavu Raju

IPC: A61M37/00

CPC classification number: A61M37/0092 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/6805 ,  A61B6/032 ,  A61B6/037 ,  A61B8/08 ,  A61B8/4227 ,  A61M2037/0007

Abstract: Ultrasound mediated delivery (USMD), real-time quantitative feedback derived (S264) therefrom, and proceeding by the system based on the feedback all are, in some embodiments, operable automatically and without need for user intervention. USMD may occur in a clinical setting accompanied by assays (S276) or real-time feedback, or by means of a wearable device that, based on feedback, regulates USMD in real time. Optionally, the user is provided an indication (S281) as to progress or success, of a treatment. Electrodes (128) may be attached across tissue in which transient pores are produced via sonoporation in the USMD procedure, and in vivo measurement is taken of an electrical parameter responsive to permeability. Therapeutic agent (S202) may be administered after particles activated for sonoporation are cleared from the circulation, to avoid, when it might exist, adverse interaction between the particles and agent.

Abstract translation: 在一些实施例中，超声介导递送（USMD），从其导出的实时定量反馈（S264）以及由系统基于反馈进行的所有这些都是可自动操作的，而不需要用户干预。 USMD可能发生在伴随测定（S276）或实时反馈的临床设置中，或者通过基于反馈实时调节USMD的可穿戴设备发生。 可选地，向用户提供关于治疗的进展或成功的指示（S281）。 电极（128）可以穿过在USMD程序中经由声孔产生瞬时孔的组织，并且体内测量响应于渗透性的电参数。 治疗剂（S202）可以在用于进行超声波活化的颗粒从循环中清除之后施用，以避免在可能存在的情况下颗粒和试剂之间的不利相互作用。

公开(公告)号：US10099044B2

公开(公告)日：2018-10-16

申请号：US14348122

申请日：2012-09-27

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Balasundar Iyyavu Raju ,  Christopher Stephen Hall ,  Ralf Seip ,  Todd Nicholas Erpelding

IPC: A61M37/00

Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.

公开(公告)号：US20140243736A1

公开(公告)日：2014-08-28

申请号：US14348122

申请日：2012-09-27

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Balasundar Iyyavu Raju ,  Christopher Stephen Hall ,  Ralf Seip ,  Todd Nicholas Erpelding

IPC: A61M37/00

CPC classification number: A61M37/0092 ,  A61M2037/0007

Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.

Abstract translation: 用于使用能量来运送物质（144）的装置，以在活化部位保护另一物质（156）的另一物质（156）的副作用，在另一个位置被递送和/或将被递送。 激活可以是非侵入性的，远程的，并且能量束（140）可以是超声波束。 第一种物质可以在特定的能量水平被激活，然后第二种物质在较低的水平被激活，使得携带第一物质的颗粒群在第二物质的活化期间不会被无意地激活。 该装置可以包括用于控制施加的能量水平的系统。