公开(公告)号：US20210138012A1

公开(公告)日：2021-05-13

申请号：US17150168

申请日：2021-01-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yoon-Young SUNG ,  Yun Mi LEE ,  Eun Jung SON ,  Heung Joo YUK ,  Young-Sil LEE

IPC: A61K36/42 ,  A61P11/06 ,  A23L33/00 ,  A23L33/105

Abstract: A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.

公开(公告)号：US20240123015A1

公开(公告)日：2024-04-18

申请号：US18278227

申请日：2021-12-13

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Young Sook KIM ,  Heung Joo YUK ,  Yun Mi LEE ,  Yoon-Young SUNG ,  Eun Jung SON

IPC: A61K36/538 ,  A61P21/00

CPC classification number: A61K36/538 ,  A61P21/00 ,  A61K2236/331 ,  A61K2236/333

Abstract: A composition for strengthening, developing, differentiating, or regenerating muscle, or preventing, ameliorating, or treating muscle loss or muscle fatigue includes a Schizonepeta tenuifolia extract as an effective component. The Schizonepeta tenuifolia extract as an effective component has the effects of restoring the viability of muscle cells, increasing the endurance time on the rotarod performance test, i.e., the holding time without falling off from the rod, compared to the control group, reducing the content of LDH, AST, and ALT in blood, increasing the grip strength, enhancing the expression amount of energy metabolism-related genes in muscle tissues, increasing the density of muscle fibers in muscle tissues, inducing a change in the fibroblast arrangement to have a well-organized structure, and reducing the expression of MuRF1 in muscle tissues, as compared to the control group.