公开(公告)号：US20210138012A1

公开(公告)日：2021-05-13

申请号：US17150168

申请日：2021-01-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yoon-Young SUNG ,  Yun Mi LEE ,  Eun Jung SON ,  Heung Joo YUK ,  Young-Sil LEE

IPC: A61K36/42 ,  A61P11/06 ,  A23L33/00 ,  A23L33/105

Abstract: A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.

公开(公告)号：US20150343005A1

公开(公告)日：2015-12-03

申请号：US14759471

申请日：2014-01-10

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook KIM ,  Jung Hyun KIM ,  Chan Sik KIM ,  Young Sook KIM ,  Eun Jin SHON ,  Yun Mi LEE ,  Dong Ho JUNG ,  Ik Soo LEE ,  Gyu Hyeong JO ,  Joo Hwan KIM

IPC: A61K36/25 ,  A61K31/155 ,  A61K36/708 ,  A61K36/488 ,  A23L1/30 ,  A61K36/482 ,  A61K36/45 ,  A61K36/73 ,  A61K36/87 ,  A61K36/718 ,  A61K36/16

CPC classification number: A61K36/25 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/155 ,  A61K36/16 ,  A61K36/45 ,  A61K36/482 ,  A61K36/488 ,  A61K36/708 ,  A61K36/718 ,  A61K36/73 ,  A61K36/87 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.

Abstract translation: 本发明涉及一种用于预防，治疗或改善糖尿病并发症或血管性水肿的药物组合物和健康功能性食品组合物，其含有恒河螺旋叶和黄连的混合提取物作为活性成分。 更具体地，本发明涉及用于预防，治疗或改善糖尿病并发症或血管性水肿的药物组合物和健康功能性食品组合物，其进一步含有大黄，葛根，银杏叶，焦糖精，蓝莓，越桔，覆盆子的提取物 ，或葡萄籽作为活性成分，以及中草螺旋叶和黄连的混合提取物。

公开(公告)号：US20240123015A1

公开(公告)日：2024-04-18

申请号：US18278227

申请日：2021-12-13

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Young Sook KIM ,  Heung Joo YUK ,  Yun Mi LEE ,  Yoon-Young SUNG ,  Eun Jung SON

IPC: A61K36/538 ,  A61P21/00

CPC classification number: A61K36/538 ,  A61P21/00 ,  A61K2236/331 ,  A61K2236/333

Abstract: A composition for strengthening, developing, differentiating, or regenerating muscle, or preventing, ameliorating, or treating muscle loss or muscle fatigue includes a Schizonepeta tenuifolia extract as an effective component. The Schizonepeta tenuifolia extract as an effective component has the effects of restoring the viability of muscle cells, increasing the endurance time on the rotarod performance test, i.e., the holding time without falling off from the rod, compared to the control group, reducing the content of LDH, AST, and ALT in blood, increasing the grip strength, enhancing the expression amount of energy metabolism-related genes in muscle tissues, increasing the density of muscle fibers in muscle tissues, inducing a change in the fibroblast arrangement to have a well-organized structure, and reducing the expression of MuRF1 in muscle tissues, as compared to the control group.

公开(公告)号：US20190099465A1

公开(公告)日：2019-04-04

申请号：US16086672

申请日：2017-04-07

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Ohn Soon KIM ,  Yun Mi LEE ,  Young-Sil LEE ,  Eun Jung SON

IPC: A61K36/9062 ,  A61K45/06 ,  A61P19/06 ,  A23L33/105

CPC classification number: A61K36/9062 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/21 ,  A61K45/06 ,  A61K2236/331 ,  A61P19/06

Abstract: The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of Alpinia oxyphylla as an effective ingredient. Because the extract of Alpinia oxyphylla of the present invention can reduce the uric acid amount in blood of an animal model and is derived from natural products, and the raw materials can be easily obtained, it can be widely used in industries that are related to hyperuricemia or metabolic disorders related with hyperuricemia. It can be effectively used for prevention, amelioration, or treatment of gout or gouty arthritis, in particular.

公开(公告)号：US20170182107A1

公开(公告)日：2017-06-29

申请号：US15313341

申请日：2015-05-21

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook KIM ,  Junghyun KIM ,  Chan-Sik KIM ,  Eunjin SHON ,  Yun Mi LEE ,  Sojin CHOI ,  Ik Soo LEE ,  Young Sook KIM ,  Dong Ho JUNG ,  Bo-Jeong PYUN ,  Seung-Hyun JUNG

IPC: A61K36/65 ,  A61K36/54

CPC classification number: A61K36/65 ,  A61K36/54

Abstract: The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy. and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.

公开(公告)号：US20200268827A1

公开(公告)日：2020-08-27

申请号：US16646387

申请日：2018-09-12

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yun Mi LEE ,  Eun Jung SON ,  Ji Youn KIM

IPC: A61K36/9062 ,  A61P19/02

Abstract: A method for treating osteoarthritis according to an embodiment of the present invention includes administering to a subject in need thereof a composition comprising an extract of Alpinia oxyphylla. The extract of Alpinia oxyphylla can reduce the expression of IL-1β, IL-6, TNF-α and COX-2 as an inflammatory factor and also the expression of MMP-9 as a cartilage degeneration-inducing factor, and can heal the cartilage damage, and thus it can be advantageously used as a functional health food composition for prevention or improvement of osteoarthritis or a therapeutic agent for osteoarthritis.

公开(公告)号：US20170209510A1

公开(公告)日：2017-07-27

申请号：US15313654

申请日：2015-05-21

Applicant: Korea Institute of Oriental Medicine

Inventor： Jin Sook KIM ,  Junghyun KIM ,  Chan-Sik KIM ,  Eunjin SHON ,  Yun Mi LEE ,  Young Sook KIM ,  Sojin CHOI ,  Ik Soo LEE ,  Dong Ho JUNG ,  Bo-Jeong PYUN ,  Seung-Hyun JUNG

IPC: A61K36/65 ,  A61K36/484

CPC classification number: A61K36/65 ,  A61K36/484 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/37 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.