公开(公告)号：US20210138012A1

公开(公告)日：2021-05-13

申请号：US17150168

申请日：2021-01-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yoon-Young SUNG ,  Yun Mi LEE ,  Eun Jung SON ,  Heung Joo YUK ,  Young-Sil LEE

IPC: A61K36/42 ,  A61P11/06 ,  A23L33/00 ,  A23L33/105

Abstract: A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.

公开(公告)号：US20190099465A1

公开(公告)日：2019-04-04

申请号：US16086672

申请日：2017-04-07

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Ohn Soon KIM ,  Yun Mi LEE ,  Young-Sil LEE ,  Eun Jung SON

IPC: A61K36/9062 ,  A61K45/06 ,  A61P19/06 ,  A23L33/105

CPC classification number: A61K36/9062 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/21 ,  A61K45/06 ,  A61K2236/331 ,  A61P19/06

Abstract: The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of Alpinia oxyphylla as an effective ingredient. Because the extract of Alpinia oxyphylla of the present invention can reduce the uric acid amount in blood of an animal model and is derived from natural products, and the raw materials can be easily obtained, it can be widely used in industries that are related to hyperuricemia or metabolic disorders related with hyperuricemia. It can be effectively used for prevention, amelioration, or treatment of gout or gouty arthritis, in particular.