公开(公告)号：US11332479B2

公开(公告)日：2022-05-17

申请号：US16731277

申请日：2019-12-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gamal El-din Mahmoud ,  Hong Seok Choi ,  Kyung Ho Yoo ,  Dong Keun Han ,  Chang Hyun Oh ,  Abdel-Maksoud Mohammed ,  I. El-Gamal Mohammed ,  Usama M. Ammar

IPC: C07D498/04 ,  C07D513/04 ,  A61P35/00

Abstract: Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

公开(公告)号：US10570155B2

公开(公告)日：2020-02-25

申请号：US16315263

申请日：2017-07-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gamal El-din Mahmoud ,  Hong Seok Choi ,  Kyung Ho Yoo ,  Dong Keun Han ,  Chang Hyun Oh ,  Abdel-Maksoud Mohammed ,  I. El-Gamal Mohammed

IPC: C07D513/04 ,  C07D498/04 ,  A61P35/00

Abstract: Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

公开(公告)号：US09968712B1

公开(公告)日：2018-05-15

申请号：US15377372

申请日：2016-12-13

Applicant: Korea Institute of Science and Technology

Inventor： Dong Keun Han ,  Yoon Ki Joung ,  Eugene Lih ,  Yun Ah Kim

IPC: A61K9/00 ,  A61L27/58 ,  A61L27/56 ,  A61L27/10 ,  A61L27/54 ,  A61L27/34 ,  A61L27/18 ,  A61L27/36 ,  A61L27/26 ,  C12N5/00

CPC classification number: A61L27/58 ,  A61K9/0024 ,  A61L27/10 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2400/18 ,  C12N5/0068 ,  C12N2533/90

Abstract: Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

公开(公告)号：US08852624B2

公开(公告)日：2014-10-07

申请号：US13633342

申请日：2012-10-02

Applicant: Korea Institute of Science and Technology

Inventor： Dong Keun Han ,  Yoon Ki Joung ,  Jong Hee Kang ,  Ji Yeon Choi ,  Chang Hun Kum

IPC: A61K9/50 ,  A61K31/74

CPC classification number: A61L17/145 ,  A61L27/306 ,  A61L27/34 ,  A61L27/446 ,  A61L27/58 ,  A61L31/088 ,  A61L31/10 ,  A61L31/128 ,  A61L31/148 ,  A61L2420/04 ,  B82Y5/00 ,  C08L67/04

Abstract: A biomedical implant according to this invention comprises ceramic complex, which includes a surface-modified basic ceramic particles, which are basic ceramic particles modified their surface with first biodegradable polymers, and the second biodegradable polymers. The first and second biodegradable polymer are combined each other and form a stereo complex. The biomedical implant has a superior effect to suppress inflammation caused by degradation of biodegradable polymers with improving its mechanical property.

Abstract translation: 根据本发明的生物医学植入物包括陶瓷复合物，其包括表面改性的碱性陶瓷颗粒，其是用第一可生物降解聚合物改性其表面的碱性陶瓷颗粒和第二可生物降解聚合物。 第一和第二生物可降解聚合物彼此组合并形成立体复合物。 生物医学植入物具有优异的抑制可生物降解聚合物降解引起的炎症的作用，具有改善其机械性能。