公开(公告)号：US20240151728A1

公开(公告)日：2024-05-09

申请号：US18487614

申请日：2023-10-16

Applicant: Korea Institute of Science and Technology ,  SEOUL NATIONAL UNIVERSITY R&db FOUNDATION

Inventor： Jihye SEONG ,  Mihue Jang ,  Haenim Lee ,  Hyejin Yoo ,  Chang-Han Lee ,  Jiyun Jeong ,  Hang-Rae Kim ,  Soojin Lee

IPC: G01N33/574 ,  G01N33/533 ,  G01N33/542 ,  G01N33/68

CPC classification number: G01N33/57492 ,  G01N33/533 ,  G01N33/542 ,  G01N33/6845 ,  C12N2503/00

Abstract: The disclosure relates to a fluorescence resonance energy transfer (FRET)-based biosensor for sensing chimeric antigen receptor (CAR) activity and use thereof, and in particular, to a FRET-based biosensor, which simultaneously detects binding of an antigen-binding receptor domain to a cancer antigen and consequent activation of T cells, and a method of screening for CAR activity in a live cell by using the FRET-based biosensor.

公开(公告)号：US20220396553A1

公开(公告)日：2022-12-15

申请号：US17415382

申请日：2018-12-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ae Nim PAE ,  Yun Kyung KIM ,  Sang Min LIM ,  Sungsu LIM ,  Jihye SEONG ,  Jae Wook LEE ,  Ji Yeon SONG ,  Seulgi SHIN ,  Hyean Jeong JEONG ,  Woo Seung SON ,  Haeun LEE ,  Da Mi LIM ,  Seok Kyu KIM ,  Jee Yun AHN ,  Chae Won KIM ,  Ashwini Machhindra LONDHE ,  Lizaveta GOTINA ,  Hyojin KIM ,  Hye Yeon LEE ,  Nam Gyung KIM ,  Eunji CHA ,  Kunhee KIM ,  Ji Woong LIM

IPC: C07D241/42 ,  C07D239/34 ,  C07D239/30 ,  C07D239/26 ,  C07D277/28 ,  C07C255/66 ,  C07D487/04 ,  C07D471/04 ,  C07D231/12 ,  C07D209/14 ,  C07D231/56 ,  C07D215/38 ,  C07D417/12 ,  C07D417/04 ,  C07D277/82 ,  C07D237/14

Abstract: The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

公开(公告)号：US20210096133A1

公开(公告)日：2021-04-01

申请号：US16778306

申请日：2020-01-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jihye SEONG ,  Hyun-bin KIM

IPC: G01N33/58 ,  C07K14/705 ,  C07K14/435

Abstract: Provided are a red fluorescent protein-based biosensor for measuring the activity of dopamine receptor D1, a method of measuring the activity of dopamine receptor D1 using the biosensor, and a method of detecting a ligand binding to dopamine receptor D1.

公开(公告)号：US20180312509A1

公开(公告)日：2018-11-01

申请号：US15738225

申请日：2017-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Youngjae KIM ,  Jihye SEONG ,  Ghil Soo NAM ,  Yong Seo CHO

IPC: C07D487/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/4162 ,  A61K31/55 ,  A61P25/22 ,  A61P25/24 ,  C07D498/04 ,  Y02P20/55

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.