公开(公告)号：US20200207649A1

公开(公告)日：2020-07-02

申请号：US16390007

申请日：2019-04-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seong Pil JEONG ,  Jae Woo CHOI ,  Kyungjin CHO ,  Hien Thi NGUYEN ,  Youngjae KIM ,  Am JANG ,  Seunghak LEE ,  Seockheon LEE

IPC: C02F3/04 ,  E03B3/06 ,  E03B3/34 ,  C02F1/00 ,  C02F3/34

Abstract: Provided is an aquifer storage and recovery system, in which microbes extracted from an underground aquifer are involved in an assimilable organic carbon (AOC) removal mechanism and applied to an aerobic reactor, and a predetermined portion of assimilable organic carbon in raw water is removed through the aerobic reactor.

公开(公告)号：US20200325043A1

公开(公告)日：2020-10-15

申请号：US16677679

申请日：2019-11-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seong Pil JEONG ,  Kyungjin CHO ,  Jae Woo CHOI ,  Seok Won HONG ,  Seunghak LEE ,  Eun-Ju KIM ,  Jae Shik CHUNG ,  Hien Thi NGUYEN ,  Youngjae KIM

IPC: C02F1/52 ,  E03B3/34

Abstract: The present invention is an aquifer storage and recovery system using a natural coagulant, in which in purifying raw water through aquifer storage and recovery, assimilable organic carbon (AOC) included in the raw water is effectively removed using a natural coagulant produced in the aquifer storage and recovery process, thereby reducing the time required to purify raw water by aquifer storage and recovery.

公开(公告)号：US20180312509A1

公开(公告)日：2018-11-01

申请号：US15738225

申请日：2017-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Youngjae KIM ,  Jihye SEONG ,  Ghil Soo NAM ,  Yong Seo CHO

IPC: C07D487/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/4162 ,  A61K31/55 ,  A61P25/22 ,  A61P25/24 ,  C07D498/04 ,  Y02P20/55

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.

公开(公告)号：US20160244408A1

公开(公告)日：2016-08-25

申请号：US14629821

申请日：2015-02-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Gyo Chang KEUM ,  Youngjae KIM ,  MI Young YEOM

IPC: C07D209/86 ,  C07D401/06 ,  C07D413/06 ,  C07D403/06

CPC classification number: C07D209/86 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: Disclosed are carbazole derivatives and pharmaceutically acceptable salts thereof that act on the 5-HT7 receptor. The carbazole derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for the 5-HT7 serotonin receptor and antagonistic activities against the 5-HT7 serotonin receptor. Further disclosed are pharmaceutical compositions including the compounds as active ingredients. The pharmaceutical compositions are useful as therapeutic and prophylactic agents for central nervous system diseases where antagonistic activities against 5-HT7 are required, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, circadian rhythm dysregulation, sleep disturbance, and smooth muscle-related diseases.

Abstract translation: 公开了作用于5-HT 7受体的咔唑衍生物及其药学上可接受的盐。 咔唑衍生物及其药学上可接受的盐对5-HT7血清素受体具有高结合亲和力，对5-HT7血清素受体具有拮抗活性。 进一步公开了包含作为活性成分的化合物的药物组合物。 药物组合物可用作中枢神经系统疾病的治疗和预防剂，其中需要针对5-HT7的拮抗活性，例如抑郁症，偏头痛，焦虑症，疼痛，炎性疼痛，神经性疼痛，体温调节异常，昼夜节律紊乱，睡眠 干扰和平滑肌相关疾病。