公开(公告)号：US20150329533A1

公开(公告)日：2015-11-19

申请号：US14632839

申请日：2015-02-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Kyung Il CHOI ,  Jung Hyun KIM ,  Ae Nim PAE ,  Jin Ri HONG ,  Jae Kyun LEE

IPC: C07D417/14 ,  C07D401/12 ,  C07D417/06 ,  C07D231/12

CPC classification number: C07D231/12 ,  C07D401/12 ,  C07D417/06 ,  C07D417/14

Abstract: Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.

Abstract translation: 本文公开了可用作钙离子通道阻断剂的N-（吡唑基甲基）芳基磺酰胺衍生物及其药学上可接受的盐，其药物用途为其钙离子通道阻断作用的治疗剂。

公开(公告)号：US20180312509A1

公开(公告)日：2018-11-01

申请号：US15738225

申请日：2017-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah CHOO ,  Youngjae KIM ,  Jihye SEONG ,  Ghil Soo NAM ,  Yong Seo CHO

IPC: C07D487/04 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/4162 ,  A61K31/55 ,  A61P25/22 ,  A61P25/24 ,  C07D498/04 ,  Y02P20/55

Abstract: Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.

公开(公告)号：US20140343295A1

公开(公告)日：2014-11-20

申请号：US14013487

申请日：2013-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Kyung Il CHOI ,  Ae Nim PAE ,  Seon Hee SEO ,  Hyun Ah CHOO ,  Gyo Chang KEUM ,  Jung Hyun KIM

IPC: C07D403/12

CPC classification number: C07D403/12 ,  A61K31/4155

Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

Abstract translation: 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学用途。

公开(公告)号：US20210255203A1

公开(公告)日：2021-08-19

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Hyun Ah CHOO ,  Ahmed A. Elbatrawy ,  Gyo Chang KEUM ,  Yun Kyung KIM ,  Sung Su LIM ,  Jae Kyun LEE ,  Eun Kyoung BANG

IPC: G01N33/68 ,  C07D215/20 ,  C07D401/06

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.