公开(公告)号：US20150044665A1

公开(公告)日：2015-02-12

申请号：US14061011

申请日：2013-10-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan-Hyi LEE ,  Jong-Hoon CHOI ,  Jong-Wook LEE ,  Hyun-Kwang SEOK ,  Mintai Peter HWANG ,  Jang-won SONG

IPC: G01N33/554 ,  G01N33/58 ,  C12N15/10 ,  C12N7/00

CPC classification number: G01N33/554 ,  C07K2319/20 ,  C07K2319/21 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/10222 ,  C12N2795/10231 ,  C12N2810/50 ,  C12N2810/859 ,  G01N33/588

Abstract: The present invention relates to a target-specific probe containing T7 bacteriophage with a targeting antibody, and a detection method or a detection kit for a biomarker using the target-specific probe. The biomarker can be detected by using the genetically-modified T7 bacteriophage expressing various heterogeneous proteins and peptides on its surface and antibody-antigen specific reaction which can make the probe targeted to a biomarker or bacteria; and a detectable labeling agent, for example a quantum dot.

Abstract translation: 本发明涉及含有靶向抗体的T7噬菌体的靶特异性探针，以及使用靶特异性探针的生物标志物的检测方法或检测试剂盒。 可以通过使用在其表面上表达各种异质蛋白质和肽的遗传修饰的T7噬菌体和可以使探针靶向生物标志物或细菌的抗体 - 抗原特异性反应来检测生物标志物; 和可检测的标记试剂，例如量子点。