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公开(公告)号：US11957724B2
公开(公告)日：2024-04-16
申请号：US17038442
申请日：2020-09-30
申请人： ERYTECH PHARMA
发明人： Flavie Pouillot , Hélène Blois
IPC分类号： A61K35/76 , A01N63/40 , C07K14/005 , C12N7/00 , C12Q1/18 , G01N33/569
CPC分类号： A61K35/76 , A01N63/40 , C07K14/005 , C12N7/00 , C12Q1/18 , G01N33/56916 , C12N2795/00021 , C12N2795/00022 , C12N2795/00031 , C12N2795/00032 , C12N2795/00071 , C12N2795/10121 , C12N2795/10122 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , C12N2795/10221 , C12N2795/10222 , C12N2795/10231 , C12N2795/10232 , C12N2795/10271 , G01N2333/245 , G01N2800/52
摘要： The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.
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公开(公告)号：US20170000831A1
公开(公告)日：2017-01-05
申请号：US15110769
申请日：2015-01-09
申请人： PHERECYDES PHARMA
发明人： FLAVIE POUILLOT , HÉLÈNE BLOIS
CPC分类号： A61K35/76 , A01N63/00 , C07K14/005 , C12N7/00 , C12N2795/00021 , C12N2795/00022 , C12N2795/00031 , C12N2795/00032 , C12N2795/00071 , C12N2795/10121 , C12N2795/10122 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , C12N2795/10221 , C12N2795/10222 , C12N2795/10231 , C12N2795/10232 , C12N2795/10271 , C12Q1/18 , G01N33/56916 , G01N2333/245 , G01N2800/52
摘要： The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.
摘要翻译： 本发明涉及噬菌体治疗。 更具体地，本发明涉及对大肠杆菌菌株具有高特异性的新型噬菌体，其制备方法，其组分，包含该噬菌体的组合物及其在噬菌体治疗中的用途。
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公开(公告)号：US20160309723A1
公开(公告)日：2016-10-27
申请号：US15174589
申请日：2016-06-06
发明人： Carlos F. Gonzalez , Stephen J. Ahern , Mayukh Das , Ryland F. Young, III , Tushar Surva Bhowmick
CPC分类号： A01N63/00 , C12N7/00 , C12N15/8281 , C12N2795/10121 , C12N2795/10131 , C12N2795/10221 , C12N2795/10231 , C12N2795/10321 , C12N2795/10331 , C12R1/91
摘要： Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
摘要翻译： 提供方法和组合物用于预防或减少与植物中的Xylla fastidiosa或Xanthomonas axonopodis相关的症状或疾病。 本发明提供了对Xylella fastidiosa或Xanthomonas axonopodis（包括XfaMija和XfaMijo）有毒的新型噬菌体，并进一步提供了在植物中治疗或预防皮肤病或柑橘类Canker的方法。
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公开(公告)号：US20160083696A1
公开(公告)日：2016-03-24
申请号：US14770420
申请日：2014-02-24
发明人： Eun Mi SHIN , Gi Duk BAE , Jae Won KIM
CPC分类号： C12N7/00 , A01N63/00 , A23K20/195 , A61K35/76 , C12N2795/10221 , C12N2795/10231 , C12N2795/10233
摘要： Provided is a novel bacteriophage ΦCJ20 (KCCM11362P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic Escherichia coli in animals except for humans using the bacteriophage ΦCJ20 (KCCM11362P) or the antibacterial composition containing the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient.
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公开(公告)号：US12006531B2
公开(公告)日：2024-06-11
申请号：US16674876
申请日：2019-11-05
IPC分类号： C12Q1/66 , C12N15/86 , G01N33/569 , G01N33/58
CPC分类号： C12Q1/66 , C12N15/86 , G01N33/569 , G01N33/56911 , G01N33/581 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243
摘要： Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.
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公开(公告)号：US11667895B2
公开(公告)日：2023-06-06
申请号：US16865748
申请日：2020-05-04
发明人： Asma Hatoum , Shreyas Rao
CPC分类号： C12N7/00 , C12N9/2402 , C12Q1/70 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243 , C12Y302/01036
摘要： Disclosed herein is an engineered bacteriophage comprising an indicator gene, wherein said indicator gene is an RNA aptamer or a green fluorescent protein (GFP) or GFP-like protein, and further wherein said indicator gene can indicate the presence of a microorganism, such as a bacterial infection. The engineered bacteriophage can be capable of infecting and killing the microorganism. The engineered microorganism can be in a composition for delivery to a subject, and can be in hyaluronic acid, for example. Also disclosed are methods of using the engineered bacteriophage to diagnose and/or treat a subject with a bacterial infection.
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公开(公告)号：US09657277B2
公开(公告)日：2017-05-23
申请号：US14770429
申请日：2014-02-24
发明人： Eun Mi Shin , Gi Duk Bae , Jae Won Kim
IPC分类号： C12N7/00 , A61K35/76 , A01N63/00 , A23L3/3463 , A23L2/44 , A23K10/18 , A23K20/195 , A23K50/30
CPC分类号： C12N7/00 , A01N63/00 , A23K10/18 , A23K20/195 , A23K50/30 , A23L2/44 , A23L3/3463 , A61K35/76 , C12N2795/10221 , C12N2795/10231 , C12N2795/10233
摘要： Provided is a novel bacteriophage ΦCJ19 (KCCM11361P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ19 (KCCM11361P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic Escherichia coli in animals except for humans using the bacteriophage ΦCJ19 (KCCM11361P) or the antibacterial composition containing the bacteriophage ΦCJ19 (KCCM11361P) as an active ingredient.
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公开(公告)号：US20160302426A1
公开(公告)日：2016-10-20
申请号：US15174564
申请日：2016-06-06
CPC分类号： A01N63/00 , C12N7/00 , C12N2795/10221 , C12N2795/10231 , C12N2795/10233 , C12N2795/10251 , C12N2795/10321 , C12N2795/10331 , C12R1/91
摘要： The present invention provides methods for development of a virulent bacteriophage-based treatment for the control of plant diseases caused by Xylella fastidiosa. The invention further provides methods of isolating and propagating bacteriophage virulent to X. fastidiosa in a Xanthomonas bacterial host and for treating or reducing symptoms of X. fastidiosa infection in a plant. The invention further provides methods of isolating and propagating bacteriophage virulent to Xanthomonas axonopodis pv. citri and for treating or reducing symptoms of Xanthomonas axonopodis pv. citri infection in a plant.
摘要翻译： 本发明提供了用于开发用于控制由Xylella fastidiosa引起的植物病害的基于有毒性噬菌体的处理的方法。 本发明进一步提供了在黄单胞菌属细菌宿主中分离和繁殖毒蕈毒素至十字戟科的方法，并用于治疗或减少植物中快速疟原虫感染的症状。 本发明进一步提供了分离和繁殖毒性至黄单胞菌属（Xanthomonas axonopodis pv）的方法。 柠檬酸和用于治疗或减轻黄单胞菌属的症状。 柑橘感染在植物中。
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公开(公告)号：US08273564B2
公开(公告)日：2012-09-25
申请号：US12854814
申请日：2010-08-11
申请人： Li-Kuang Chen , Nien-Tsung Lin
发明人： Li-Kuang Chen , Nien-Tsung Lin
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2795/10131 , C12N2795/10231
摘要： The present invention provides a disinfectant composition including a phage of Acinetobacter baumannii and a carrier. The present invention also provides a method for disinfecting a medical institute or a medical research institute, including the steps of applying an effective amount of a phage of Acinetobacter baumannii to the medical institute or the medical research institute for reducing amount of Acinetobacter baumannii in the medical institute or the medical research institute.
摘要翻译： 本发明提供了包含不动杆菌不动杆菌噬菌体和载体的消毒剂组合物。 本发明还提供了一种消毒医学研究所或医学研究所的方法，包括将有效量的不动杆菌不动杆菌噬菌体应用于医疗机构或医学研究所，用于减少医疗中不动杆菌不动杆菌的量 研究所或医学研究所。
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公开(公告)号：US20240301343A1
公开(公告)日：2024-09-12
申请号：US18670411
申请日：2024-05-21
发明人： Carlos F. Gonzalez , Stephen J. Ahern , Mayukh Das , Ryland F. Young, III , Tushar Suvra Bhowmick
CPC分类号： C12N1/00 , A01N63/40 , C12N7/00 , C12N15/8281 , C12N2795/10121 , C12N2795/10131 , C12N2795/10221 , C12N2795/10231 , C12N2795/10321 , C12N2795/10331 , C12R2001/91
摘要： Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.
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