公开(公告)号：US12005152B2

公开(公告)日：2024-06-11

申请号：US17168780

申请日：2021-02-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang-Heon Kim ,  Seung Ja Oh ,  Ha Eun Chung

IPC: A61L26/00

CPC classification number: A61L26/0033 ,  A61L26/0023 ,  A61L26/008 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/60 ,  A61L27/26 ,  C08L89/06 ,  A61L27/26 ,  C08L5/08

Abstract: The present disclosure relates to a microgel composition comprising collagen and hyaluronic acid and a method of preparing the same. The microgel according to an embodiment is composed of natural biocompatible substances and is non-toxic and has high mechanical stability or long persistence, and thus can be effectively used in a microgel composition, a three-dimensional scaffold composition, and a tissue-engineering scaffold.

公开(公告)号：US12138283B2

公开(公告)日：2024-11-12

申请号：US16413278

申请日：2019-05-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang-Heon Kim ,  Seokheon Hong ,  Seung Ja Oh ,  Kwi Deok Park

IPC: A61K35/28 ,  A61K9/16 ,  C12N5/0775

Abstract: Provided is a method of preparing a three-dimensional cell spheroid, the method including forming the cell spheroid by co-culturing adipose-derived stem cells or mesenchymal stem cells with hepatocytes. According to the cell spheroid prepared by the method, the secretome secreted by the adipose-derived stem cells affects hepatocyte maturation, and therefore, hepatic functions of the finally formed three-dimensional cell spheroid, i.e., organoid, may be enhanced. Further, a composition including a culture medium of the adipose-derived stem cells may prevent or treat liver diseases including hepatitis, hepatotoxicity, cholestasis, fatty liver, etc., and may enhance hepatic functions.