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公开(公告)号：US11667891B2
公开(公告)日：2023-06-06
申请号：US16898072
申请日：2020-06-10
发明人： Hojeong Jeon , Youngmin Seo , Hyunseon Seo , Myoung-Ryul Ok , Yu Chan Kim , Hyun Kwang Seok , Seung Ja Oh
IPC分类号： C12N5/0786 , C12M1/42 , C12M1/34 , C12M1/12 , C12N5/078
CPC分类号： C12N5/0645 , C12M25/02 , C12M35/04 , C12M41/40 , C12N5/0643 , C12N2506/115 , C12N2521/00 , C12N2533/30
摘要： Provided is a method for the selective differentiation into M1 macrophages under a pressurized environment, and more particularly, a method for the selective differentiation of undifferentiated macrophages into M1 macrophages, the method including incubating the undifferentiated macrophages in an incubator under the pressurized environment. In addition, provided is a method for producing osteoclasts, the method including: incubating undifferentiated macrophages in an incubator under a pressurized environment to differentiate into M1 macrophages; and differentiating the differentiated M1 macrophages into osteoclasts.
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公开(公告)号：US11241517B2
公开(公告)日：2022-02-08
申请号：US16165515
申请日：2018-10-19
发明人： Sang Heon Kim , Joo Young Lee , Seung Ja Oh
IPC分类号： A61L27/24 , B33Y70/00 , B29C64/40 , A61L27/20 , A61L27/22 , A61L27/26 , A61L27/38 , A61L27/52 , B33Y10/00 , B29K105/00
摘要： Provided are a hydrogel composition with high viscoelasticity and a bioink composition including the hydrogel composition. The hydrogel composition according to an embodiment is composed of natural biocompatible substances and thus is not toxic, but has high viscosity, resulting in high mechanical stability or long persistence. Thus, the hydrogel composition may be usefully utilized as a bioink composition for bioprinting, a support in tissue engineering, or a soft tissue filler.
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公开(公告)号：US12005152B2
公开(公告)日：2024-06-11
申请号：US17168780
申请日：2021-02-05
发明人： Sang-Heon Kim , Seung Ja Oh , Ha Eun Chung
IPC分类号： A61L26/00
CPC分类号： A61L26/0033 , A61L26/0023 , A61L26/008 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/60 , A61L27/26 , C08L89/06 , A61L27/26 , C08L5/08
摘要： The present disclosure relates to a microgel composition comprising collagen and hyaluronic acid and a method of preparing the same. The microgel according to an embodiment is composed of natural biocompatible substances and is non-toxic and has high mechanical stability or long persistence, and thus can be effectively used in a microgel composition, a three-dimensional scaffold composition, and a tissue-engineering scaffold.
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