公开(公告)号：US11667891B2

公开(公告)日：2023-06-06

申请号：US16898072

申请日：2020-06-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Youngmin Seo ,  Hyunseon Seo ,  Myoung-Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Seung Ja Oh

IPC: C12N5/0786 ,  C12M1/42 ,  C12M1/34 ,  C12M1/12 ,  C12N5/078

CPC classification number: C12N5/0645 ,  C12M25/02 ,  C12M35/04 ,  C12M41/40 ,  C12N5/0643 ,  C12N2506/115 ,  C12N2521/00 ,  C12N2533/30

Abstract: Provided is a method for the selective differentiation into M1 macrophages under a pressurized environment, and more particularly, a method for the selective differentiation of undifferentiated macrophages into M1 macrophages, the method including incubating the undifferentiated macrophages in an incubator under the pressurized environment. In addition, provided is a method for producing osteoclasts, the method including: incubating undifferentiated macrophages in an incubator under a pressurized environment to differentiate into M1 macrophages; and differentiating the differentiated M1 macrophages into osteoclasts.