公开(公告)号：US11766548B2

公开(公告)日：2023-09-26

申请号：US17153969

申请日：2021-01-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Industry-University Cooperation Foundation Hanyang University ERICA Campus

Inventor： Myoung-Ryul Ok ,  So Yeon Kim ,  Yoon Ki Joung ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Hyung-Seop Han ,  Hojeong Jeon ,  Hyunseon Seo ,  Inho Kim ,  Kyoung Won Park ,  Yongwoo Chung ,  Jaekyun Kim

IPC: A61M37/00 ,  A61N5/06

CPC classification number: A61M37/0015 ,  A61N5/062 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: Provided are phototherapeutic needle patches usable for phototherapy by using needle patches capable of injecting drugs or cosmetic substances to patients, and methods of manufacturing the same. A phototherapeutic needle patch may include a patch body attachable to skin of a patient, at least one microneedle protruding from the patch body, one end of the microneedle configured to deliver a drug through stratum corneum of the skin to inner tissues of the skin, and light grooves formed in a concave shape along a length direction of the microneedle in such a manner that therapeutic light radiated from a light source for phototherapy easily penetrates into the skin along the microneedle.

公开(公告)号：US11452594B2

公开(公告)日：2022-09-27

申请号：US16836925

申请日：2020-04-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Myoung-Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok

IPC: A61F2/16 ,  A61F2/00

Abstract: Provided is an intraocular lens including: an optic portion; and a haptic portion extending from the optic portion, wherein a pattern having ridges and grooves is formed on at least one of the optic portion and the haptic portion, and each of the grooves has a nanostructure roughness. Provided also is a method of manufacturing an intraocular lens, the method including: seating an object to be processed including an optic portion and at least one haptic portion extending from the optic portion, processing a predetermined pattern for guiding cells by performing laser irradiation on the haptic portion and the optic portion, forming grooves having a nanostructure surface roughness in the predetermined pattern formed by laser beams, and the surface of each of the grooves has an average roughness Ra less than 200 nm.

公开(公告)号：US11109959B2

公开(公告)日：2021-09-07

申请号：US16512400

申请日：2019-07-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ho Jeong Jeon ,  Myoung Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Choun Ki Joo ,  Byoung Chan Choi

IPC: A61F2/16

Abstract: There is provided an intraocular lens including an optic portion having a circular shape from one side thereof and including a first pattern which includes a ridge and a groove, and a plurality of haptic portions extending from an outer circumferential edge of the optic portion and each including a second pattern which includes a ridge and a groove, in which at least one of the ridges included in the first pattern and the second pattern and at least one of the grooves included in the first pattern and the second pattern includes a section in which a width is formed differently.

公开(公告)号：US10976224B2

公开(公告)日：2021-04-13

申请号：US15753115

申请日：2016-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Indong Jun ,  Kangwon Lee ,  Hyung-Seop Han ,  Jimin Park ,  Myoung-Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok

IPC: G01N1/31 ,  C12N5/00 ,  B01J19/00 ,  G01N33/50

Abstract: A cell patterning material, a method of preparing the cell patterning material, a cell patterning method using the cell patterning material, and a biosensor including patterned cells obtained by using the cell patterning method are provided. According to the present disclosure, cells may be conveniently and efficiently patterned and the time for applying external stimulation for patterning may be controlled. In addition, the patterned cells may have an excellent proliferation rate and excellent differentiation efficiency, and may be re-patterned in a different direction, and High-throughput screening using the patterned cells is possible.

公开(公告)号：US11738123B2

公开(公告)日：2023-08-29

申请号：US16891195

申请日：2020-06-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Myoung-Ryul Ok ,  Jimin Park ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Hyung-Seop Han ,  Hojeong Jeon ,  Hyunseon Seo ,  Jee-Wook Lee ,  Jin Kyung Jeon ,  Gayoung Jung ,  Jong Woong Park ,  Ji Hun Park

IPC: A61L31/16 ,  A61B17/86 ,  A61B17/80 ,  A61K9/00 ,  A61K33/00 ,  A61L31/02 ,  F16B35/04 ,  A61F2/28 ,  A61B17/00 ,  C25D11/00

CPC classification number: A61L31/16 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/866 ,  A61F2/2846 ,  A61K9/0024 ,  A61K33/00 ,  A61L31/022 ,  F16B35/04 ,  A61B2017/00893 ,  C25D11/00

Abstract: Provided is an implant having a controlled generation rate of reactive oxygen species and a method of controlling generation of reactive oxygen species using the same. The implant having a controlled generation rate of reactive oxygen species according to the present invention includes a body formed of a metallic material and having a groove, a first filling metal filling one region of the groove, and a second filling metal filling the groove on the first filling metal, wherein the second filling metal has an ionization tendency different from that of the first filling metal.

公开(公告)号：US11434570B2

公开(公告)日：2022-09-06

申请号：US17338110

申请日：2021-06-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Seung Hoon Um ,  Jae Ho Park ,  Justin Jihong Chung ,  Hyunseon Seo ,  Hyung-Seop Han ,  Yu Chan Kim ,  Myoung-Ryul Ok ,  Hyun Kwang Seok

IPC: C23C26/00 ,  B23K26/352 ,  B23K26/122 ,  C01B25/32

Abstract: Provided is a method of forming an apatite coating, the method including immersing a substrate in an apatite-forming precursor solution including Ca2+ ions and PO43− ions, emitting a laser beam onto a surface of the substrate immersed in the precursor solution, and forming an apatite coating in a region exposed to the laser beam, wherein an output power of the laser beam is set within a range enabling the surface of the substrate to be melted.

公开(公告)号：US11970394B2

公开(公告)日：2024-04-30

申请号：US17130536

申请日：2020-12-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Seung Hoon Um ,  Yu Chan Kim ,  Hyung-Seop Han ,  Myoung-Ryul Ok ,  Hyunseon Seo ,  Hyun Kwang Seok

IPC: C01B25/32 ,  B01J19/12 ,  B23K26/122

CPC classification number: C01B25/32 ,  B01J19/121 ,  B23K26/122 ,  B01J2219/0801 ,  C01P2002/01 ,  C01P2004/03 ,  C01P2004/04

Abstract: Provided is a method of synthesizing apatite powder by emitting a laser beam to a surface of a substrate immersed in a precursor solution. The method is including immersing a substrate in an apatite-forming precursor solution, emitting a laser beam to a region on a surface of the substrate immersed in the precursor solution, and obtaining apatite powder generated in the precursor solution.

公开(公告)号：US11667891B2

公开(公告)日：2023-06-06

申请号：US16898072

申请日：2020-06-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Youngmin Seo ,  Hyunseon Seo ,  Myoung-Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Seung Ja Oh

IPC: C12N5/0786 ,  C12M1/42 ,  C12M1/34 ,  C12M1/12 ,  C12N5/078

CPC classification number: C12N5/0645 ,  C12M25/02 ,  C12M35/04 ,  C12M41/40 ,  C12N5/0643 ,  C12N2506/115 ,  C12N2521/00 ,  C12N2533/30

Abstract: Provided is a method for the selective differentiation into M1 macrophages under a pressurized environment, and more particularly, a method for the selective differentiation of undifferentiated macrophages into M1 macrophages, the method including incubating the undifferentiated macrophages in an incubator under the pressurized environment. In addition, provided is a method for producing osteoclasts, the method including: incubating undifferentiated macrophages in an incubator under a pressurized environment to differentiate into M1 macrophages; and differentiating the differentiated M1 macrophages into osteoclasts.

公开(公告)号：US09645141B2

公开(公告)日：2017-05-09

申请号：US14093305

申请日：2013-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi Lee ,  Ho Young Park ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Seok Lee

IPC: G01N33/543

CPC classification number: G01N33/54326

Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.