公开(公告)号：US11667891B2

公开(公告)日：2023-06-06

申请号：US16898072

申请日：2020-06-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Youngmin Seo ,  Hyunseon Seo ,  Myoung-Ryul Ok ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Seung Ja Oh

IPC: C12N5/0786 ,  C12M1/42 ,  C12M1/34 ,  C12M1/12 ,  C12N5/078

CPC classification number: C12N5/0645 ,  C12M25/02 ,  C12M35/04 ,  C12M41/40 ,  C12N5/0643 ,  C12N2506/115 ,  C12N2521/00 ,  C12N2533/30

Abstract: Provided is a method for the selective differentiation into M1 macrophages under a pressurized environment, and more particularly, a method for the selective differentiation of undifferentiated macrophages into M1 macrophages, the method including incubating the undifferentiated macrophages in an incubator under the pressurized environment. In addition, provided is a method for producing osteoclasts, the method including: incubating undifferentiated macrophages in an incubator under a pressurized environment to differentiate into M1 macrophages; and differentiating the differentiated M1 macrophages into osteoclasts.

公开(公告)号：US11970394B2

公开(公告)日：2024-04-30

申请号：US17130536

申请日：2020-12-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Seung Hoon Um ,  Yu Chan Kim ,  Hyung-Seop Han ,  Myoung-Ryul Ok ,  Hyunseon Seo ,  Hyun Kwang Seok

IPC: C01B25/32 ,  B01J19/12 ,  B23K26/122

CPC classification number: C01B25/32 ,  B01J19/121 ,  B23K26/122 ,  B01J2219/0801 ,  C01P2002/01 ,  C01P2004/03 ,  C01P2004/04

Abstract: Provided is a method of synthesizing apatite powder by emitting a laser beam to a surface of a substrate immersed in a precursor solution. The method is including immersing a substrate in an apatite-forming precursor solution, emitting a laser beam to a region on a surface of the substrate immersed in the precursor solution, and obtaining apatite powder generated in the precursor solution.

公开(公告)号：US11231778B2

公开(公告)日：2022-01-25

申请号：US16902040

申请日：2020-06-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunseon Seo ,  Inchan Youn ,  Hyojin Lee ,  Kang-Il Song ,  Donghee Son

IPC: H05K1/18 ,  G06F3/01 ,  C08K3/08 ,  C08G77/388 ,  H05K1/02 ,  H05K1/09 ,  H05K3/14 ,  H05K3/28 ,  H05K1/11

Abstract: A bidirectional self-healing neural interface includes a first elastic substrate; a neural electrode disposed on the first elastic substrate and comprising a conductive polymer composite; and a second elastic substrate disposed on the neural electrode. The conductive polymer composite includes a matrix formed of a self-healing polymer material; and a plurality of electrical conductor clusters distributed in the matrix. Each of the electrical conductor clusters includes particles of a first electrical conductor; and a plurality of particles of a second electrical conductor formed of the same material as that of the first electrical conductor, distributed around each of the particles of the first electrical conductor, and having sizes that are smaller than those of the particles of the first electrical conductor. The first electrical conductor is a source for generating the second electrical conductor. The neural interface has excellent elasticity, electrical conductivity that is improved by deformation, and is self-healing.

公开(公告)号：US11738123B2

公开(公告)日：2023-08-29

申请号：US16891195

申请日：2020-06-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Myoung-Ryul Ok ,  Jimin Park ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Hyung-Seop Han ,  Hojeong Jeon ,  Hyunseon Seo ,  Jee-Wook Lee ,  Jin Kyung Jeon ,  Gayoung Jung ,  Jong Woong Park ,  Ji Hun Park

IPC: A61L31/16 ,  A61B17/86 ,  A61B17/80 ,  A61K9/00 ,  A61K33/00 ,  A61L31/02 ,  F16B35/04 ,  A61F2/28 ,  A61B17/00 ,  C25D11/00

CPC classification number: A61L31/16 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/866 ,  A61F2/2846 ,  A61K9/0024 ,  A61K33/00 ,  A61L31/022 ,  F16B35/04 ,  A61B2017/00893 ,  C25D11/00

Abstract: Provided is an implant having a controlled generation rate of reactive oxygen species and a method of controlling generation of reactive oxygen species using the same. The implant having a controlled generation rate of reactive oxygen species according to the present invention includes a body formed of a metallic material and having a groove, a first filling metal filling one region of the groove, and a second filling metal filling the groove on the first filling metal, wherein the second filling metal has an ionization tendency different from that of the first filling metal.

公开(公告)号：US11434570B2

公开(公告)日：2022-09-06

申请号：US17338110

申请日：2021-06-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong Jeon ,  Seung Hoon Um ,  Jae Ho Park ,  Justin Jihong Chung ,  Hyunseon Seo ,  Hyung-Seop Han ,  Yu Chan Kim ,  Myoung-Ryul Ok ,  Hyun Kwang Seok

IPC: C23C26/00 ,  B23K26/352 ,  B23K26/122 ,  C01B25/32

Abstract: Provided is a method of forming an apatite coating, the method including immersing a substrate in an apatite-forming precursor solution including Ca2+ ions and PO43− ions, emitting a laser beam onto a surface of the substrate immersed in the precursor solution, and forming an apatite coating in a region exposed to the laser beam, wherein an output power of the laser beam is set within a range enabling the surface of the substrate to be melted.

公开(公告)号：US11766548B2

公开(公告)日：2023-09-26

申请号：US17153969

申请日：2021-01-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Industry-University Cooperation Foundation Hanyang University ERICA Campus

Inventor： Myoung-Ryul Ok ,  So Yeon Kim ,  Yoon Ki Joung ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Hyung-Seop Han ,  Hojeong Jeon ,  Hyunseon Seo ,  Inho Kim ,  Kyoung Won Park ,  Yongwoo Chung ,  Jaekyun Kim

IPC: A61M37/00 ,  A61N5/06

CPC classification number: A61M37/0015 ,  A61N5/062 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: Provided are phototherapeutic needle patches usable for phototherapy by using needle patches capable of injecting drugs or cosmetic substances to patients, and methods of manufacturing the same. A phototherapeutic needle patch may include a patch body attachable to skin of a patient, at least one microneedle protruding from the patch body, one end of the microneedle configured to deliver a drug through stratum corneum of the skin to inner tissues of the skin, and light grooves formed in a concave shape along a length direction of the microneedle in such a manner that therapeutic light radiated from a light source for phototherapy easily penetrates into the skin along the microneedle.