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1.发明授权公开(公告)号：US10267737B2
公开(公告)日：2019-04-23
申请号：US15824157
申请日：2017-11-28
Inventor： Chang-Soo Lee , Chul Soon Park , Oh Seok Kwon , Tai Hwan Ha
IPC: C07F9/06 , G01N21/64 , C12N9/18 , C07D209/10 , C07D311/80 , C09K11/06
Abstract: A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.
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公开(公告)号：US12055517B2
公开(公告)日：2024-08-06
申请号：US16759432
申请日：2018-10-29
Inventor： Oh Seok Kwon , Chang Soo Lee , Seon Joo Park , Tai Hwan Ha , Chul Soon Park , Kyung Ho Kim , Jin Yeong Kim
IPC: B32B9/00 , C01B32/186 , C01B32/194 , G01N27/414 , H10K85/20 , H10K85/60 , B82Y30/00
CPC classification number: G01N27/4145 , C01B32/186 , C01B32/194 , G01N27/4146 , H10K85/20 , H10K85/6572 , B82Y30/00 , C01B2204/02 , C01B2204/04 , C01B2204/22 , C01P2002/82 , C01P2002/86 , Y10T428/30
Abstract: The present invention relates to a graphene transistor comprising: a substrate; a graphene channel layer arranged on the substrate; a pair of metals spaced from each other and respectively arranged at opposite ends of the graphene channel layer; and a linker layer arranged on the graphene channel layer and including an N-heterocyclic carbene compound, a fabrication method therefor, and a biosensor comprising the same. The graphene transistor according to the present invention in which the carbene group of the N-heterocyclic carbene compound forms a covalent bond with the graphene channel layer to modify the whole surface of the graphene channel layer exhibits excellent electric conductivity as a transistor and a biosensor comprising the transistor is improved in selectivity and sensitivity.
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