公开(公告)号：US20160228402A1

公开(公告)日：2016-08-11

申请号：US15022546

申请日：2013-11-08

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sei Ryang OH ,  Yong Yeon CHO ,  Hyung Won RYU ,  Cheol Jung LEE ,  Hye Suk LEE ,  Doo Young KIM ,  Jung Hee KIM ,  Kyung Seop AHN ,  Mee Hyun LEE ,  Hyeong Kyu LEE

IPC: A61K31/34 ,  A61K45/06 ,  A61K36/898

CPC classification number: A61K31/34 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/36 ,  A61K36/575 ,  A61K36/898 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/308 ,  A23V2250/21 ,  A61K31/06

Abstract: The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition.Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.

Abstract translation: 本发明涉及用于预防，改善或治疗癌症的药物组合物。 更具体地说，本发明涉及包含具有特定化学结构的木脂素化合物（化学式1）的用于预防或治疗癌症的药物组合物。 一种用于预防或改善包括木脂素化合物在内的癌症的健康功能性食品组合物; 以及使用该组合物预防，改善或治疗癌症的方法。 此外，本发明涉及木素素化合物在制备用于预防，改善或治疗癌症的药物组合物或保健功能性食品组合物中的用途。

公开(公告)号：US20160051612A1

公开(公告)日：2016-02-25

申请号：US14780503

申请日：2014-04-09

Applicant: YUNGJIN PHARMACEUTICAL CO., LTD. ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Yongnam LEE ,  Ji-seok YOO ,  Dae-hee SHIN ,  Byung-hwan RYOO ,  Kyung Seop AHN ,  Sei Ryang OH ,  Hyeong Kyu LEE ,  In Sik SHIN ,  Doo Young KIM ,  Ok-Kyoung KWON ,  Hyuk Hwan SONG ,  Seung Hyung KIM ,  SuUi LEE

IPC: A61K36/68 ,  A61K31/192 ,  A61K31/7048

CPC classification number: A61K31/192 ,  A23L33/105 ,  A61K31/194 ,  A61K31/7048 ,  A61K36/80 ,  A61K2236/00

Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).

Abstract translation: 一种组合物，其包含从Pseudolysimachion rotundum var。 含有大量活性成分的亚结构或从其分离的化合物作为治疗慢性阻塞性肺部疾病的活性成分及其用途。 发明纯化的提取物和化合物通过各种体内试验以及体外试验显示出有效的抗COPD活性，而没有β-2-受体激动反应。 因此，它可以用作治疗和预防慢性阻塞性肺疾病（COPD）的治疗剂或功能性保健食品。

公开(公告)号：US20180353561A1

公开(公告)日：2018-12-13

申请号：US15573207

申请日：2016-05-13

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sei-Ryang OH ,  Kyung Seop AHN ,  Su Ui LEE ,  Hyung Won RYU ,  Doo-Young KIM ,  Hyeong Kyu LEE ,  Ok-Kyoung KWON ,  Jung Hee KIM ,  Hyun-Jun LEE ,  In-Sik SHIN

IPC: A61K36/575 ,  A61K31/34 ,  A61K31/357 ,  A61P35/00 ,  A61P9/00

CPC classification number: A61K36/575 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/34 ,  A61K31/357 ,  A61K31/36 ,  A61K47/38 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00

Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

公开(公告)号：US20170266142A1

公开(公告)日：2017-09-21

申请号：US15384302

申请日：2016-12-19

Applicant: YUNGJIN PHARMACEUTICAL CO., LTD ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Yongnam LEE ,  Ji-seok YOO ,  Dae-hee SHIN ,  Byung-hwan RYOO ,  Kyung Seop AHN ,  Sei Ryang OH ,  Hyeong Kyu LEE ,  In Sik SHIN ,  Doo Young KIM ,  Ok-Kyoung KWON ,  Hyuk Hwan SONG ,  Seung Hyung KIM ,  SuUi LEE

IPC: A61K31/192 ,  A61K36/80 ,  A61K31/7048 ,  A23L33/105 ,  A61K31/194

CPC classification number: A61K31/192 ,  A23L33/105 ,  A61K31/194 ,  A61K31/7048 ,  A61K36/80 ,  A61K2236/00

Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).