公开(公告)号：US20240261356A1

公开(公告)日：2024-08-08

申请号：US18290222

申请日：2022-05-11

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Su Ui LEE ,  Mun-Ock KIM ,  Hyung Won RYU ,  Sei-Ryang OH ,  Doo-Young KIM ,  Jae-Won LEE

IPC: A61K36/254 ,  A61K31/191 ,  A61K31/365 ,  A61K36/38 ,  A61P1/16

CPC classification number: A61K36/254 ,  A61K31/191 ,  A61K31/365 ,  A61K36/38 ,  A61P1/16 ,  A61K2236/39

Abstract: The present invention relates to a composition containing extracts from Garcinia cambogia and Acanthopanax for prevention or treatment of liver diseases and, more specifically, to a composition for prevention or treatment of liver disease, the composition containing, as active ingredients, (i) a Garcinia cambogia extract, hydroxycitric acid (HCA), or a derivative of hydroxycitric acid; and (ii) an Acanthopanax extract, Chiisanogenin, or a derivative of Chiisanogenin.

公开(公告)号：US20180353561A1

公开(公告)日：2018-12-13

申请号：US15573207

申请日：2016-05-13

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sei-Ryang OH ,  Kyung Seop AHN ,  Su Ui LEE ,  Hyung Won RYU ,  Doo-Young KIM ,  Hyeong Kyu LEE ,  Ok-Kyoung KWON ,  Jung Hee KIM ,  Hyun-Jun LEE ,  In-Sik SHIN

IPC: A61K36/575 ,  A61K31/34 ,  A61K31/357 ,  A61P35/00 ,  A61P9/00

CPC classification number: A61K36/575 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/34 ,  A61K31/357 ,  A61K31/36 ,  A61K47/38 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00

Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

公开(公告)号：US20240254155A1

公开(公告)日：2024-08-01

申请号：US18564361

申请日：2022-05-04

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyung Won RYU ,  Su Ui LEE ,  Sei-Ryang OH ,  Jae-Won LEE ,  Doo-Young KIM ,  Hyun-Jae JANG ,  Mun-Ock KIM ,  Seong Hun JEONG

IPC: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08

CPC classification number: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention relates to a novel compound isolated from spinach, and a composition comprising same for preventing or treating inflammatory diseases, and, more particularly, to a novel medicagenic acid glycoside compound isolated from spinach, a preparation method therefor, and a composition comprising same for preventing or treating inflammatory diseases.

公开(公告)号：US20170174645A1

公开(公告)日：2017-06-22

申请号：US15449465

申请日：2017-03-03

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Kyeong LEE ,  Sei-Ryang OH ,  Kyung Seop AHN ,  Ok-Kyoung KWON ,  Doo-Young KIM ,  Hyung Won RYU ,  Jung Hee KIM ,  Xuezhen XU

IPC: C07D307/86 ,  A23L33/10

CPC classification number: C07D307/86 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/343 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81

Abstract: The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.

公开(公告)号：US20160332980A1

公开(公告)日：2016-11-17

申请号：US15221025

申请日：2016-07-27

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Kyeong LEE ,  Sei-Ryang OH ,  Kyung Seop AHN ,  Ok-Kyoung KWON ,  Doo-Young KIM ,  Hyung Won RYU ,  Jung Hee KIM ,  Xuezhen XU

IPC: C07D307/78 ,  C07C41/01 ,  C07C43/23

CPC classification number: C07D307/78 ,  A61K31/05 ,  A61K31/343 ,  C07C41/01 ,  C07C43/23 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81

Abstract: The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.

Abstract translation: 本发明涉及一种新的2-苯基苯并呋喃衍生物或其药学上可接受的盐，其制备方法和用于预防或治疗包含其的活性成分的炎性疾病的药物组合物，并且该新的2-苯基苯并呋喃 衍生物或其药学上可接受的盐在抑制由巨噬细胞诱导的NO，IL-6和TNF-α中显着有效，因此可有利地用于预防或治疗炎性疾病的药物组合物中。