公开(公告)号：US20180353561A1

公开(公告)日：2018-12-13

申请号：US15573207

申请日：2016-05-13

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sei-Ryang OH ,  Kyung Seop AHN ,  Su Ui LEE ,  Hyung Won RYU ,  Doo-Young KIM ,  Hyeong Kyu LEE ,  Ok-Kyoung KWON ,  Jung Hee KIM ,  Hyun-Jun LEE ,  In-Sik SHIN

IPC: A61K36/575 ,  A61K31/34 ,  A61K31/357 ,  A61P35/00 ,  A61P9/00

CPC classification number: A61K36/575 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/34 ,  A61K31/357 ,  A61K31/36 ,  A61K47/38 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00

Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

公开(公告)号：US20170035822A1

公开(公告)日：2017-02-09

申请号：US15304316

申请日：2015-04-17

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Sei Ryang OH ,  Kyung Seop AHN ,  Seung Hyung KIM ,  In Sik SHIN ,  Hang JIN ,  Jung Hee KIM ,  Hyung Won RYU ,  Wan Yi LI ,  Sang Woo LEE ,  Joong Ku LEE ,  Sang Ho CHOI

IPC: A61K36/22 ,  A61K9/00 ,  A23L33/105 ,  A61K31/12

Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-α, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.

Abstract translation: 本发明涉及一种抑制慢性阻塞性肺疾病（COPD）的组合物，其包含维斯特氏菌提取物，其分数或从其分离的化合物，更具体地，涉及用于预防或治疗COPD的药物组合物，所述药物组合物包含猕猴桃提取物（Pistacia weinmannifolia extract） ，其一部分，或从其分离的化合物; 用于预防或改善COPD的食物组合物和从其分离的化合物。 根据本发明的包含猕猴桃提取物，其馏分或从其分离的化合物的组合物是无毒的，抑制炎性细胞侵入COPD诱导的动物模型的支气管中，并有效地抑制 CXCL-1，TNF-α或MIP-2的表达。 此外，由于使用经安全验证的草药作为原料，本发明的组合物可以解决现有的COPD治疗剂，慢性阻塞性支气管炎，慢性细支气管炎，肺气肿，多发性硬化症， 和急性和慢性炎症，因此可以有效地用作预防，治疗和治疗COPD的组合物。

公开(公告)号：US20240261356A1

公开(公告)日：2024-08-08

申请号：US18290222

申请日：2022-05-11

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Su Ui LEE ,  Mun-Ock KIM ,  Hyung Won RYU ,  Sei-Ryang OH ,  Doo-Young KIM ,  Jae-Won LEE

IPC: A61K36/254 ,  A61K31/191 ,  A61K31/365 ,  A61K36/38 ,  A61P1/16

CPC classification number: A61K36/254 ,  A61K31/191 ,  A61K31/365 ,  A61K36/38 ,  A61P1/16 ,  A61K2236/39

Abstract: The present invention relates to a composition containing extracts from Garcinia cambogia and Acanthopanax for prevention or treatment of liver diseases and, more specifically, to a composition for prevention or treatment of liver disease, the composition containing, as active ingredients, (i) a Garcinia cambogia extract, hydroxycitric acid (HCA), or a derivative of hydroxycitric acid; and (ii) an Acanthopanax extract, Chiisanogenin, or a derivative of Chiisanogenin.

公开(公告)号：US20170217982A1

公开(公告)日：2017-08-03

申请号：US15328056

申请日：2015-07-22

Applicant: YUNGJIN PHARMACEUTICAL CO., LTD ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Yongnam LEE ,  Ji-seok YOO ,  Dae-hee SHIN ,  Byung-hwan RYOO ,  Sei-ryang OH ,  Kyung-seop AHN ,  Hyeongkyu LEE ,  Su Ui LEE ,  Hyuk-hwan SONG ,  In Sik SHIN ,  Hyung Won RYU

IPC: C07D493/08 ,  A61K36/68 ,  A23L2/52 ,  A23L33/155 ,  A23L33/15 ,  A23L33/16 ,  A61K31/357 ,  A23L33/105

CPC classification number: C07D493/08 ,  A23L2/52 ,  A23L33/105 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23V2002/00 ,  A61K31/357 ,  A61K36/68 ,  A61K36/80 ,  C07H17/04

Abstract: A compound (3R,5S,5aS,6R,7S,8R,8aS)-8-chloro-8a-hydroxy-5-(2-hydroxy acetoxy) hexahydro-1H-3,6-methanocyclopenta[e][1,3]dioxepin-7-yl 3,4-dihydroxybenzoate (KS534), the isomer thereof, the pharmaceutically acceptable salt or solvates thereof, a composition comprising the same as an active ingredient for treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD)

公开(公告)号：US20220151979A1

公开(公告)日：2022-05-19

申请号：US17439577

申请日：2020-02-26

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyo-Soo KIM ,  Hyun-Duk JANG ,  Kyung Seop AHN ,  Sei-Ryang OH ,  Ji Won PARK ,  Ok-Kyoung KWON ,  Hyung Won RYU

IPC: A61K31/352 ,  A61K31/40 ,  A61K31/505 ,  A61K31/47 ,  A61K31/22 ,  A61K31/366 ,  A61K31/405 ,  A61P9/10

Abstract: The present invention relates to a composition for prevention or treatment of cardiovascular and metabolic diseases, containing noranhydroicaritin or a pharmaceutically acceptable salt thereof, and the noranhydroicaritin or pharmaceutically acceptable salt thereof of the present invention is not toxic to cells, is thus safe, inhibits the production of PCSK9, promotes the production of LDLR, and is highly utilizable as a composition for prevention or treatment of cardiovascular and metabolic diseases. The noranhydroicaritin of the present invention can be used in a food composition for prevention or improvement of cardiovascular and metabolic diseases, a functional food composition for prevention or improvement of cardiovascular and metabolic diseases, and a method of preventing or treating cardiovascular and metabolic diseases, which includes administering a composition containing noranhydroicaritin as an active ingredient.

公开(公告)号：US20160228402A1

公开(公告)日：2016-08-11

申请号：US15022546

申请日：2013-11-08

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sei Ryang OH ,  Yong Yeon CHO ,  Hyung Won RYU ,  Cheol Jung LEE ,  Hye Suk LEE ,  Doo Young KIM ,  Jung Hee KIM ,  Kyung Seop AHN ,  Mee Hyun LEE ,  Hyeong Kyu LEE

IPC: A61K31/34 ,  A61K45/06 ,  A61K36/898

CPC classification number: A61K31/34 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/36 ,  A61K36/575 ,  A61K36/898 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/308 ,  A23V2250/21 ,  A61K31/06

Abstract: The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition.Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.

Abstract translation: 本发明涉及用于预防，改善或治疗癌症的药物组合物。 更具体地说，本发明涉及包含具有特定化学结构的木脂素化合物（化学式1）的用于预防或治疗癌症的药物组合物。 一种用于预防或改善包括木脂素化合物在内的癌症的健康功能性食品组合物; 以及使用该组合物预防，改善或治疗癌症的方法。 此外，本发明涉及木素素化合物在制备用于预防，改善或治疗癌症的药物组合物或保健功能性食品组合物中的用途。

公开(公告)号：US20240254155A1

公开(公告)日：2024-08-01

申请号：US18564361

申请日：2022-05-04

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyung Won RYU ,  Su Ui LEE ,  Sei-Ryang OH ,  Jae-Won LEE ,  Doo-Young KIM ,  Hyun-Jae JANG ,  Mun-Ock KIM ,  Seong Hun JEONG

IPC: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08

CPC classification number: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention relates to a novel compound isolated from spinach, and a composition comprising same for preventing or treating inflammatory diseases, and, more particularly, to a novel medicagenic acid glycoside compound isolated from spinach, a preparation method therefor, and a composition comprising same for preventing or treating inflammatory diseases.

公开(公告)号：US20230364170A1

公开(公告)日：2023-11-16

申请号：US18024604

申请日：2021-08-18

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Su Ui LEE ,  Hyung Won RYU ,  Mun Ock KIM ,  Sei Ryang OH ,  Doo Young KIM ,  Hyun Jae JANG

IPC: A61K36/258 ,  A61K31/585 ,  A61K36/38 ,  A61K31/194 ,  A61P3/08 ,  A61P3/04

CPC classification number: A61K36/258 ,  A61K31/585 ,  A61K36/38 ,  A61K31/194 ,  A61P3/08 ,  A61P3/04

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating obesity or diabetes, and to a food composition and feed composition for preventing or alleviating obesity or diabetes, comprising as an active ingredient, an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. The composition has synergistic antidiabetic and antiobesity activity compared to that of using only an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. Therefore, it is possible to reduce the possibility of any side effects that may be caused by an overdose of or long-term administration of the garcinia cambogia extract and a substance isolated therefrom, and thus the composition can be very effectively utilized in the development of a therapeutic agent for diabetes or obesity.

公开(公告)号：US20230144344A1

公开(公告)日：2023-05-11

申请号：US17910894

申请日：2021-03-11

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyo-soo KIM ,  Hyun-duk JANG ,  Kyung Seop AHN ,  Sei-Ryang OH ,  Ok-Kyoung KWON ,  Hyung Won RYU ,  Hang JIN ,  Sangho CHOI ,  Sang Woo LEE ,  Jin Hyub PAIK ,  Soo Yong KIM ,  Changyoung LEE ,  Yong In KIM ,  Hyewon KIM ,  Mijin PARK

IPC: A61K36/185 ,  A61K31/7048 ,  A61P9/00

CPC classification number: A61K36/185 ,  A61K31/7048 ,  A61P9/00 ,  A61K2236/333 ,  A61K2236/35

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cardiovascular and metabolic diseases, comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom, as an active ingredient; a food composition for preventing or improving cardiovascular and metabolic diseases; and a method for preventing or treating cardiovascular and metabolic diseases using the same.
The composition comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom inhibits the binding of Resistin-CAP1 to inhibit the production of tumor necrosis factor, and thereby has an activity of inhibiting inflammation of the cardiovascular system, and thus can be effectively used as a preventive or therapeutic measure for cardiovascular and metabolic diseases.

公开(公告)号：US20170174645A1

公开(公告)日：2017-06-22

申请号：US15449465

申请日：2017-03-03

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Kyeong LEE ,  Sei-Ryang OH ,  Kyung Seop AHN ,  Ok-Kyoung KWON ,  Doo-Young KIM ,  Hyung Won RYU ,  Jung Hee KIM ,  Xuezhen XU

IPC: C07D307/86 ,  A23L33/10

CPC classification number: C07D307/86 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/343 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81

Abstract: The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.