公开(公告)号：US20180027843A1

公开(公告)日：2018-02-01

申请号：US15547229

申请日：2016-01-28

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： Woo Song Lee ,  Hyung Jae Jeong ,  Mun Chual Rho ,  Young Bae Ryu ,  Hyung Jun Kwon ,  Su Jin Park ,  Ji Young Park

IPC分类号： A23K20/10

CPC分类号： A23K20/10 ,  A23K10/26 ,  A23K10/30 ,  A23K20/158 ,  A23K50/00 ,  A23K50/48

摘要： The present invention relates to a composition for removing an amine-based compound, comprising an oleoresin turmeric extract, a fraction thereof, or water-soluble curcumin, a licorice extract or a fraction thereof, and a salmon milt extract as an active ingredient; and a composition for feed and feed additive comprising the same. The composition of the present invention can reduce an amine-based compound such as ammonia in animal excrement that causes the odor, and thereby reduce the odor caused by the amine-based compound and provide an effect of improving a feeding environment.

公开(公告)号：US11464787B2

公开(公告)日：2022-10-11

申请号：US16339130

申请日：2017-09-29

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： Mun Chual Rho ,  Seung Woong Lee ,  Soyoung Lee ,  Sang-Hyun Kim ,  Kwon Moo Park ,  Woo Song Lee ,  Kyungsook Jung ,  Chan Sun Park

IPC分类号： A61K31/56 ,  A61P13/12 ,  A61K33/243

摘要： The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.

公开(公告)号：US20220265753A1

公开(公告)日：2022-08-25

申请号：US17744872

申请日：2022-05-16

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Young Bae RYU ,  Sang Woo Lee ,  Sang Ho Choi ,  Ji Young Park ,  Hyung Jun Kwon ,  In Chul Lee ,  Jong Sub Lee ,  Woo Song Lee ,  Wan Yi Li

IPC分类号： A61K36/60 ,  A23L33/105 ,  A61P5/24

摘要： The present invention relates to a method of preventing or alleviating symptoms of andropause comprising administering a pharmaceutically effective amount of an extract of Ficus auriculata Lour. To a patient in need thereof. The extract of Ficus auriculata Lour. of the present invention exhibits the effect of preventing and alleviating erectile dysfunction by inhibiting the activity of PDE5, and the effect of preventing and alleviating prostatic hyperplasia by suppressing the expression of AR and PSA.

公开(公告)号：US10920248B2

公开(公告)日：2021-02-16

申请号：US16084445

申请日：2017-02-28

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Cha Young Kim ,  Yu Jeong Jeong ,  Suk Weon Kim ,  Mun Chual Rho ,  Young Bae Ryu ,  Woo Song Lee ,  Jae Cheol Jeong

IPC分类号： A01H4/00 ,  C12N5/04 ,  C12P7/22 ,  C12P17/04 ,  A01H3/04 ,  C12N5/00

摘要： The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.

公开(公告)号：US20150174186A1

公开(公告)日：2015-06-25

申请号：US14550773

申请日：2014-11-21

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： Mun Chual Rho ,  Hyun Mee Oh ,  Woo Song Lee ,  Sang Hyun Kim ,  Seung Woong Lee ,  Chan Sun Park ,  Keug Hyun Ahn

IPC分类号： A61K36/537

CPC分类号： A61K36/537

摘要： The present invention relates to a pharmaceutical composition for preventing or treating STAT3-mediated diseases, comprising a Salvia plebeia R. Br. extract or fraction thereof as an active ingredient, and to a method for treating STAT3-mediated diseases, comprising a step of injecting the composition into an individual suspected of having a STAT3-mediated disease. Furthermore, the present invention relates to a food composition and a quasi-drug composition for preventing or improving STAT3-mediated diseases, comprising the Salvia plebeia R. Br. extract or fraction thereof as an active ingredient.

摘要翻译： 本发明涉及用于预防或治疗STAT3介导的疾病的药物组合物，其包含Salvia plebeia R.Br。 提取物或其部分作为活性成分，以及治疗STAT3介导的疾病的方法，包括将组合物注射到怀疑患有STAT3介导的疾病的个体中的步骤。 此外，本发明涉及用于预防或改善STAT3介导的疾病的食物组合物和准药物组合物，其包含Salvia plebeia R.Br。 提取物或其部分作为活性成分。