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    Crystal structure of the NanR and ManNAc-6P complex, and uses thereof
    3.
    发明授权
    Crystal structure of the NanR and ManNAc-6P complex, and uses thereof 有权
    NanR和ManNAc-6P复合物的晶体结构及其用途

    公开(公告)号：US09482669B2

    公开(公告)日：2016-11-01

    申请号：US14310879

    申请日：2014-06-20

    申请人： SNU R&DB FOUNDATION ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

    发明人： Sang Ho Choi ,  Byoung Sik Kim ,  Myung Hee Kim ,  Jung Won Hwang

    IPC分类号： G01N33/569 ,  C07K14/28

    CPC分类号： G01N33/56911 ,  C07K14/28 ,  G01N2400/00 ,  G01N2500/04

    摘要： The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.

    摘要翻译： 本发明涉及通过结晶作为创伤弧菌的关键致病性调节蛋白NanR的复合物和作为NanR调节剂的ManNA6P而研究的复合物的三维结构。 此外，本发明涉及修饰的NanR蛋白，编码该蛋白的多核苷酸，包含该多核苷酸的载体和包含该载体的转化体。 此外，本发明涉及一种用于筛选调节NanR与NanR调控的基因簇的Nan操纵子的转录控制区之间的相互作用的物质或调节NanR与ManNAc-6P之间的相互作用的物质的方法， 复合物的三维结构，以及包含筛选物质的抗菌组合物。

    CRYSTAL STRUCTURE OF THE NanR AND ManNAc-6P COMPLEX, AND USES THEREOF
    4.
    发明申请
    CRYSTAL STRUCTURE OF THE NanR AND ManNAc-6P COMPLEX, AND USES THEREOF 有权
    NanR和ManNAC-6P复合物的晶体结构及其用途

    公开(公告)号：US20150010915A1

    公开(公告)日：2015-01-08

    申请号：US14310879

    申请日：2014-06-20

    申请人： SNU R&DB FOUNDATION ,  Korea Research Institute Of Bioscience And Biotechnology

    发明人： Sang Ho Choi ,  Byoung Sik Kim ,  Myung Hee Kim ,  Jung Won Hwang

    IPC分类号： G01N33/569 ,  C07K14/28

    CPC分类号： G01N33/56911 ,  C07K14/28 ,  G01N2400/00 ,  G01N2500/04

    摘要： The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.

    摘要翻译： 本发明涉及通过结晶作为创伤弧菌的关键致病性调节蛋白NanR的复合物和作为NanR调节剂的ManNA6P而研究的复合物的三维结构。 此外，本发明涉及修饰的NanR蛋白，编码该蛋白的多核苷酸，包含该多核苷酸的载体和包含该载体的转化体。 此外，本发明涉及一种用于筛选调节NanR与NanR调控的基因簇的Nan操纵子的转录控制区之间的相互作用的物质或调节NanR与ManNAc-6P之间的相互作用的物质的方法， 复合物的三维结构，以及包含筛选物质的抗菌组合物。