公开(公告)号：US20230220012A1

公开(公告)日：2023-07-13

申请号：US17998729

申请日：2021-05-13

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Jun KIM ,  Chonsaeng KIM ,  Kyun Do KIM ,  Dae Gyun AHN ,  Young Chan KWON ,  Keunbon KU ,  Hae Soo KIM ,  Hye Jin SHIN ,  Gun Young YOON ,  In Su HWANG ,  Gi Uk JEONG ,  Sun Hee LEE ,  Mi Hwa KIM ,  Su Min LEE ,  Bum Tae KIM

IPC: C07K14/005 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/005 ,  A61K39/215 ,  A61P31/14 ,  C12N2770/20022 ,  C12N2770/20034 ,  C07K2319/03

Abstract: Provided are a recombinant antigen comprising a cell membrane permeation domain comprising a polypeptide of any one of SEQ ID NOs: 1 to 22 derived from human LRRC24 and a SARS-CoV-2 antigen or a fragment thereof, a vaccine composition comprising the recombinant antigen, a gene construct comprising a polynucleotide encoding the recombinant antigen, a recombinant vector comprising the gene construct, a method for producing the SARS-CoV-2 recombinant antigen, and a kit for preventing or treating SARS-CoV-2 infection comprising the vaccine composition and users' instruction thereof, wherein the antigen exhibited higher immunogenicity against SARS-CoV-2 the neutralizing antibody was better formed in actual animal experiments, excellent protective immunity was induced, and toxicity did not appear in the toxicity test.

公开(公告)号：US20240319186A1

公开(公告)日：2024-09-26

申请号：US18271640

申请日：2022-01-11

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Hong Gi KIM ,  Jung KIM ,  Bum Tae KIM ,  Jonghwan LEE ,  Nam Hoon KIM ,  Sung Kyun LEE

IPC: G01N33/569 ,  G01N21/64 ,  G01N33/531 ,  G01N33/553

CPC classification number: G01N33/56983 ,  G01N21/6428 ,  G01N33/531 ,  G01N33/553 ,  G01N2021/6439 ,  G01N2333/165 ,  G01N2469/20

Abstract: The present invention relates to a nanowire-based immunofluorescence kit for detecting a SARS coronavirus 2 antibody, and a use thereof, and more specifically, to a zinc oxide nanowire-based immunofluorescence kit for detecting a SARS coronavirus 2 antibody, and a use thereof, the kit comprising a step of growing nanowires on a substrate, introducing a functional group on the grown nanowires, and fixing a SARS coronavirus 2 antigen. The nanowire array of the present invention has enhanced detection sensitivity to enable more accurate diagnosis of whether or not a SARS coronavirus 2 antibody is produced.

公开(公告)号：US20220306718A1

公开(公告)日：2022-09-29

申请号：US17296622

申请日：2019-12-16

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Jun KIM ,  Kyun Do KIM ,  In Su HWANG ,  Keunbon KU ,  Chonsaeng KIM ,  Bum Tae KIM ,  Dae Gyun AHN ,  Hae Soo KIM ,  Young Chan KWON

IPC: C07K14/705 ,  A61K47/64

Abstract: The present invention relates to a transmembrane domain derived from human LRRC24 protein. More specifically, the present invention relates to a transmembrane domain derived from the human LRRC24 protein (LRRC24P transmembrane domain) or a cell-penetrating peptide, and an intracellular delivery system comprising same. The transmembrane domain derived from the human LRRC24 protein of the present invention can be used to deliver cargo materials such as compounds, biomolecules, and various polymer materials into cells. Since the LRRC24P transmembrane domain of the present invention exhibits higher cell penetration efficiency compared to conventional cell-penetrating peptides and is derived from human proteins, thus avoiding side effects and immune responses caused by peptides derived from foreign proteins, it can be usefully used as an effective intracellular delivery method for compounds, biomolecules, and various polymer materials applied to the human body.

公开(公告)号：US20210047300A1

公开(公告)日：2021-02-18

申请号：US16967825

申请日：2019-01-31

Applicant: Korea Research Institute of Chemical Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Sung Youn CHANG ,  Hyuk LEE ,  Ki Young KIM ,  Bum Tae KIM ,  Sung Soo KIM ,  Seong Hwan KIM ,  Hwan Jung LIM ,  Jung Nyoung HEO ,  Sang Joon SHIN ,  Sang Youn PARK

IPC: C07D403/12 ,  C07D413/14 ,  C07D401/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/14

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

公开(公告)号：US20210047277A1

公开(公告)日：2021-02-18

申请号：US16967844

申请日：2019-01-31

Applicant: Korea Research Institute of Chemical Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Sung Youn CHANG ,  Hyuk LEE ,  Ki Young KIM ,  Bum Tae KIM ,  Sung Soo KIM ,  Seong Hwan KIM ,  Hwan Jung LIM ,  Jung Nyoung HEO ,  Sang Joon SHIN ,  Sang Youn PARK

IPC: C07D231/38 ,  C07D403/10 ,  C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D401/14 ,  A61P35/04

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

公开(公告)号：US20230160895A1

公开(公告)日：2023-05-25

申请号：US17997151

申请日：2021-06-18

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Hong Gi KIM ,  Jonghwan LEE ,  Bum Tae KIM

IPC: G01N33/569 ,  G01N33/543

CPC classification number: G01N33/56983 ,  G01N33/54346 ,  G01N2333/165 ,  G01N2333/948

Abstract: Provided are a composition for detecting SARS coronavirus 2, a composition for diagnosing SARS coronavirus 2 infection, a method for detecting SARS coronavirus 2, and a SARS coronavirus 2 infection diagnostic kit, wherein a receptor and an antibody that binds to SARS coronavirus 2 spike protein are used in order to detect SARS coronavirus 2 (SARS-CoV-2) or diagnose SARS coronavirus 2 infection (COVID-19).

公开(公告)号：US20230039679A1

公开(公告)日：2023-02-09

申请号：US17939147

申请日：2022-09-07

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sung Youn CHANG ,  Hyuk LEE ,  Ki Young KIM ,  Bum Tae KIM ,  Sung Soo KIM ,  Seong Hwan KIM ,  Hwan Jung LIM ,  Jung Nyoung HEO ,  Sang Joon SHIN ,  Sang Youn PARK

IPC: C07D231/38 ,  A61P35/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D409/04 ,  C07D417/04

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.