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公开(公告)号：US10029983B2
公开(公告)日：2018-07-24
申请号：US15724002
申请日：2017-10-03
IPC分类号： C07D207/46 , C07D207/50 , C07D207/273 , C07D207/22 , C07D413/06 , C07D409/14 , C07D403/04 , C07D401/06 , C07D413/14 , C07D405/14 , C07D209/54 , C07D417/12 , C07D413/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D405/04 , C07D401/12 , C07D401/04 , C07D403/12
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20210107869A1
公开(公告)日：2021-04-15
申请号：US16880443
申请日：2020-05-21
IPC分类号： C07D207/273 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/54 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06 , C07D207/22
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.
The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.-
公开(公告)号：US09822069B2
公开(公告)日：2017-11-21
申请号：US15039964
申请日：2014-11-27
IPC分类号： C07D207/273 , C07D209/54 , C07D417/12 , C07D207/22 , C07D409/04 , C07D401/04 , C07D413/12 , C07D413/14 , C07D403/12 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D405/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06
CPC分类号： C07D207/273 , C07D207/22 , C07D209/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20170066718A1
公开(公告)日：2017-03-09
申请号：US15039964
申请日：2014-11-27
IPC分类号： C07D207/273 , C07D401/04 , C07D409/04 , C07D405/12 , C07D417/12 , C07D403/12 , C07D401/12 , C07D409/12 , C07D413/12 , C07D409/14 , C07D209/54 , C07D401/06 , C07D413/06 , C07D413/14 , C07D207/22 , C07D405/14 , C07D405/04
CPC分类号： C07D207/273 , C07D207/22 , C07D209/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
摘要翻译： 提供具有甲酰基肽受体1（FPRL1）激动剂作用的化合物。 本发明涉及由通式（I）表示的化合物或其药理学上可接受的盐。 本发明还涉及含有由通式（I）表示的化合物或其药理学上可接受的盐的药物组合物。
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公开(公告)号：US10696630B2
公开(公告)日：2020-06-30
申请号：US16580909
申请日：2019-09-24
IPC分类号： C07D207/273 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/54 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06 , C07D207/22
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20190161445A1
公开(公告)日：2019-05-30
申请号：US16270363
申请日：2019-02-07
IPC分类号： C07D207/273 , C07D207/22 , C07D403/12 , C07D409/14 , C07D403/04 , C07D401/06 , C07D413/14 , C07D405/14 , C07D209/54 , C07D417/12 , C07D413/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D405/04 , C07D401/12 , C07D401/04 , C07D413/06
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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公开(公告)号：US20180290974A1
公开(公告)日：2018-10-11
申请号：US16011050
申请日：2018-06-18
IPC分类号： C07D207/273 , C07D207/22 , C07D403/12 , C07D409/14 , C07D403/04 , C07D401/06 , C07D413/14 , C07D405/14 , C07D209/54 , C07D417/12 , C07D413/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D405/04 , C07D401/12 , C07D401/04 , C07D413/06
CPC分类号： C07D207/273 , C07D207/22 , C07D209/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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公开(公告)号：US11261155B2
公开(公告)日：2022-03-01
申请号：US16880443
申请日：2020-05-21
IPC分类号： C07D207/273 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/54 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06 , C07D207/22 , A61K31/4015 , A61K31/4439
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.
The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.-
公开(公告)号：US10858314B2
公开(公告)日：2020-12-08
申请号：US15576345
申请日：2016-05-26
发明人： Hiroyasu Takahashi , Hiroyuki Watanabe , Kiyoshi Fujii , Mitsuhito Shibasaki , Mikako Kawashima , Megumi Kamiya , Kohei Ohata
IPC分类号： C07C275/30 , C07C275/42 , C07C275/50 , C07D231/12 , C07D239/36 , C07D271/07 , C07D271/113 , C07D285/08 , C07D285/135 , C07D413/04 , C07D333/16 , C07D333/28 , C07D263/34 , C07D271/06 , C07D213/61 , C07D261/08 , C07D307/79 , C07D285/12 , C07C317/32 , C07C317/40 , C07D263/32 , C07C311/51 , C07D257/04 , C07D273/04 , C07D277/28 , C07D271/10 , C07D249/08 , C07D311/58 , C07D249/04 , C07D417/12 , C07D413/12 , C07D249/12 , A61P31/18 , A61P29/00 , A61P35/00
摘要： The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea compound or the pharmacologically acceptable salt thereof and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.
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公开(公告)号：US20200010415A1
公开(公告)日：2020-01-09
申请号：US16580909
申请日：2019-09-24
IPC分类号： C07D207/273 , C07D403/12 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D209/54 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/04 , C07D409/14 , C07D413/06 , C07D207/22
摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
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