公开(公告)号：US09284393B2

公开(公告)日：2016-03-15

申请号：US14409912

申请日：2013-06-24

申请人： KYUSHU UNIVERSITY ,  NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Keiji Tanaka ,  Tomoyasu Hirai ,  Kazutaka Shimafuji ,  Masayuki Haraguchi ,  Motonobu Matsuyama

IPC分类号： C08F122/10 ,  G01N33/50 ,  B05D1/00 ,  B05D3/00 ,  C09D135/02 ,  C08F2/00 ,  G01N33/547

CPC分类号： C08F122/105 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B05D1/005 ,  B05D3/007 ,  C09D135/02 ,  G01N33/547

摘要： A biomolecule-compatible highly branched polymer obtained by polymerizing a monomer having an alkylene oxide and two or more radically polymerizable double bonds in a molecule in presence of a polymerization initiator in 5 mol % or more and 200 mol % or less relative to the moles of monomer, wherein molecular terminals of biomolecule-compatible highly branched polymer have one biomolecular site of at least one pair from the group of combination pairs of biotin and avidin, an antigen and antibody, polynucleotide and polynucleotide having complementary base sequence thereof, cDNA and mRNA, enzyme and substrate, an enzyme and product, an enzyme and competitive inhibitor, an enzyme (binding site) and coenzyme, an enzyme (binding site) and triazine dye, protease and protease inhibitor, Fc site and protein A, Fc site and protein G, lectin and sugar, hormone receptor and hormone, DNA and DNA binding protein, heparin and fibronectin, and heparin and laminin.

摘要翻译： 通过在聚合引发剂的存在下，在5摩尔％以上且200摩尔％以下的分子内聚合具有环氧烷烃和2个以上自由基聚合性双键的单体而获得的生物分子相容性高支化聚合物，相对于 单体，其中生物分子相容的高度支化聚合物的分子末端具有与生物素和抗生物素蛋白的组合对中的至少一对的一个生物分子位点，具有其互补碱基序列的抗原和抗体，多核苷酸和多核苷酸，cDNA和mRNA， 酶和底物，酶和产物，酶和竞争性抑制剂，酶（结合位点）和辅酶，酶（结合位点）和三嗪染料，蛋白酶和蛋白酶抑制剂，Fc位点和蛋白A，Fc位点和蛋白G ，凝集素和糖，激素受体和激素，DNA和DNA结合蛋白，肝素和纤连蛋白，以及肝素和层粘连蛋白。

公开(公告)号：US20150299349A1

公开(公告)日：2015-10-22

申请号：US14409912

申请日：2013-06-24

申请人： KYUSHU UNIVERSITY ,  NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Keiji Tanaka ,  Tomoyasu Hirai ,  Kazutaka Shimafuji ,  Masayuki Haraguchi ,  Motonobu Matsuyama

IPC分类号： C08F122/10 ,  B05D1/00 ,  B05D3/00 ,  C09D135/02

CPC分类号： C08F122/105 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B05D1/005 ,  B05D3/007 ,  C09D135/02 ,  G01N33/547

摘要： A biomolecule-compatible highly branched polymer obtained by polymerizing a monomer having an alkylene oxide and two or more radically polymerizable double bonds in a molecule in presence of a polymerization initiator in 5 mol % or more and 200 mol % or less relative to the moles of monomer, wherein molecular terminals of biomolecule-compatible highly branched polymer have one biomolecular site of at least one pair from the group of combination pairs of biotin and avidin, an antigen and antibody, polynucleotide and polynucleotide having complementary base sequence thereof, cDNA and mRNA, enzyme and substrate, an enzyme and product, an enzyme and competitive inhibitor, an enzyme (binding site) and coenzyme, an enzyme (binding site) and triazine dye, protease and protease inhibitor, Fc site and protein A, Fc site and protein G, lectin and sugar, hormone receptor and hormone, DNA and DNA binding protein, heparin and fibronectin, and heparin and laminin.

摘要翻译： 通过在聚合引发剂的存在下，在5摩尔％以上且200摩尔％以下的分子内聚合具有环氧烷烃和2个以上自由基聚合性双键的单体而获得的生物分子相容性高支化聚合物，相对于 单体，其中生物分子相容的高度支化聚合物的分子末端具有与生物素和抗生物素蛋白的组合对中的至少一对的一个生物分子位点，具有其互补碱基序列的抗原和抗体，多核苷酸和多核苷酸，cDNA和mRNA， 酶和底物，酶和产物，酶和竞争性抑制剂，酶（结合位点）和辅酶，酶（结合位点）和三嗪染料，蛋白酶和蛋白酶抑制剂，Fc位点和蛋白A，Fc位点和蛋白G ，凝集素和糖，激素受体和激素，DNA和DNA结合蛋白，肝素和纤连蛋白，以及肝素和层粘连蛋白。