公开(公告)号：US09984459B2

公开(公告)日：2018-05-29

申请号：US15091288

申请日：2016-04-05

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman ,  Zhenguo Wang ,  Atsushi Kubota ,  Jonathan Liu

IPC分类号： G06T7/00 ,  A61B5/00 ,  G06T5/50 ,  A61B5/02 ,  G06K9/52 ,  G06K9/62

CPC分类号： A61B5/0035 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/7257 ,  A61B5/7425 ,  G06K9/52 ,  G06K9/6215 ,  G06T5/50 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/20052 ,  G06T2207/20212 ,  G06T2207/30041 ,  G06T2207/30101 ,  G06T2207/30104

摘要： Methods and systems for angiographic imaging with optical coherence tomography (OCT) are described using ratio-based and angiographic deviation based calculations. In using these calculations to determine motion, arbitrary interframe permutations may be used, post-calculated, non-linear results for projection visualization may be averaged, poor matches may be eliminated on an A-line by A-line basis, windowing functions may be used to improve results, partial spectrums may be used when capturing data, and a minimum intensity threshold may be used for determining which pixels to use.

公开(公告)号：US20170065164A1

公开(公告)日：2017-03-09

申请号：US15355650

申请日：2016-11-18

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman

IPC分类号： A61B3/00 ,  G06T7/00 ,  A61B3/12 ,  A61B3/10 ,  A61B3/14

CPC分类号： A61B3/0025 ,  A61B3/0058 ,  A61B3/102 ,  A61B3/12 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

摘要翻译： 在感兴趣的区域上获取受试者的光学相干断层扫描（OCT）扫描数据，该区域可包括视盘或视网膜的黄斑。 在OCT扫描数据中识别视网膜层的层边界以便于测量。 在一个方面，与视网膜的一个或多个目标层的总后向散射信号强度和一个或多个参考层的总后向散射信号强度之间的比值相关的测量在逐个位置的基础上计算 感兴趣的OCT扫描数据。 可以收集，聚合，分析和显示与从OCT扫描数据中获取或派生的其他信息相关的测量。

公开(公告)号：US09526412B2

公开(公告)日：2016-12-27

申请号：US14579168

申请日：2014-12-22

申请人： Kabushiki Kaisha TOPCON

发明人： Qi Yang ,  Charles A. Reisman

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G01N21/47 ,  G01N21/64 ,  G06T5/00 ,  G06T7/00 ,  G01N21/17 ,  G01N21/88

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/1225 ,  A61B5/4842 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/887 ,  G06K9/00617 ,  G06K9/4604 ,  G06K9/4671 ,  G06K9/52 ,  G06K2009/4666 ,  G06T5/002 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time.

摘要翻译： 可以通过使用光学相干断层扫描（OCT）在眼睛的多个位置处以大于视网膜色素上皮（RPE）的深度成像眼睛来检测和测量眼睛的地理萎缩。 确定视网膜层的成像信号的强度相对于每个位置处的子RPE层的成像信号的强度的比率; 至少部分地基于所确定的比率确定代表值; 生成代表值的图; 并从地图中识别患病区域。 可以基于所识别的患病区域来生成轮廓和二进制图。 可以在一段时间内分析和监测所识别区域的尺寸和形状。

公开(公告)号：US09179834B2

公开(公告)日：2015-11-10

申请号：US14168303

申请日：2014-01-30

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman

IPC分类号： A61B3/10 ,  A61B3/14 ,  A61B3/00 ,  G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/0058 ,  A61B3/102 ,  A61B3/12 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

摘要翻译： 在感兴趣的区域上获取受试者的光学相干断层扫描（OCT）扫描数据，该区域可包括视盘或视网膜的黄斑。 在OCT扫描数据中识别视网膜层的层边界以便于测量。 在一个方面，与视网膜的一个或多个目标层的总后向散射信号强度和一个或多个参考层的总后向散射信号强度之间的比值相关的测量在逐个位置的基础上计算 感兴趣的OCT扫描数据。 可以收集，聚合，分析和显示与从OCT扫描数据中获取或派生的其他信息相关的测量。

公开(公告)号：US09107610B2

公开(公告)日：2015-08-18

申请号：US14071745

申请日：2013-11-05

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman ,  Qi Yang

IPC分类号： A61B3/14 ,  A61B3/10 ,  G06T7/00

CPC分类号： A61B3/102 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Based on optical coherence tomography (OCT) imaging of a portion of an eye, a mask of an anatomical feature is derived. Using the mask as a reference, a scan path is determined that is at least partially fitted to and/or partially enclosing the mask. OCT scan data corresponding to the scan path is acquired and analyzed to detect optic neuropathies.

摘要翻译： 基于眼睛的一部分的光学相干断层扫描（OCT）成像，导出解剖特征的掩模。 使用掩模作为参考，确定至少部分地配合到和/或部分地包围掩模的扫描路径。 获取并分析对应于扫描路径的OCT扫描数据以检测视神经病变。

公开(公告)号：US11481897B2

公开(公告)日：2022-10-25

申请号：US16930715

申请日：2020-07-16

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman ,  Zhenguo Wang ,  Atsushi Kubota ,  Jonathan Liu

IPC分类号： G06T7/00 ,  G06T5/50 ,  G06V10/42 ,  A61B5/00 ,  A61B5/02 ,  G06K9/62

摘要： Methods and systems for angiographic imaging with optical coherence tomography (OCT) are described using ratio-based and angiographic deviation based calculations. In using these calculations to determine motion, arbitrary interframe permutations may be used, post- calculated, non-linear results for projection visualization may be averaged, poor matches may be eliminated on an A-line by A-line basis, windowing functions may be used to improve results, partial spectrums may be used when capturing data, and a minimum intensity threshold may be used for determining which pixels to use.

公开(公告)号：US10105046B2

公开(公告)日：2018-10-23

申请号：US15355650

申请日：2016-11-18

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman

IPC分类号： A61B3/10 ,  A61B3/14 ,  A61B3/00 ,  A61B3/12 ,  G06T7/00

摘要： Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

公开(公告)号：US20170065163A1

公开(公告)日：2017-03-09

申请号：US15355391

申请日：2016-11-18

申请人： Kabushiki Kaisha TOPCON

发明人： Qi Yang ,  Charles A. Reisman

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B5/00 ,  G01B9/02 ,  G06K9/46 ,  G06K9/00 ,  G06K9/52 ,  A61B3/12 ,  G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/1225 ,  A61B5/4842 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/887 ,  G06K9/00617 ,  G06K9/4604 ,  G06K9/4671 ,  G06K9/52 ,  G06K2009/4666 ,  G06T5/002 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time.

摘要翻译： 可以通过使用光学相干断层扫描（OCT）在眼睛的多个位置处以大于视网膜色素上皮（RPE）的深度成像眼睛来检测和测量眼睛的地理萎缩。 确定视网膜层的成像信号的强度相对于每个位置处的子RPE层的成像信号的强度的比率; 至少部分地基于所确定的比率确定代表值; 生成代表值的图; 并从地图中识别患病区域。 可以基于所识别的患病区域来生成轮廓和二进制图。 可以在一段时间内分析和监测所识别区域的尺寸和形状。

公开(公告)号：US20160206190A1

公开(公告)日：2016-07-21

申请号：US14990340

申请日：2016-01-07

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman ,  Qi Yang

IPC分类号： A61B3/00 ,  A61B3/14 ,  A61B3/12 ,  A61B3/10

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time to phenotype subjects and classify diseases.

摘要翻译： 可以通过使用光学相干断层扫描（OCT）在眼睛的多个位置处以大于视网膜色素上皮（RPE）的深度成像眼睛来检测和测量眼睛的地理萎缩。 确定视网膜层的成像信号的强度相对于每个位置处的子RPE层的成像信号的强度的比率; 至少部分地基于所确定的比率确定代表值; 生成代表值的图; 并从地图中识别患病区域。 可以基于所识别的患病区域来生成轮廓和二进制图。 可以在一段时间内分析和监测所识别的区域的大小和形状以表现受试者并对疾病进行分类。

公开(公告)号：US20140293289A1

公开(公告)日：2014-10-02

申请号：US13851612

申请日：2013-03-27

申请人： Kabushiki Kaisha TOPCON

发明人： Charles A. Reisman

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02083

摘要： Methods for generating optical coherence tomography intensity maps are provided. A beam of light is generated and divided along a sample path and a reference path. The sample path beam of light is directed to locations in an X-Y plane. Light returned from each of the sample path and the reference path is received. Sets of outputs are generated, each corresponding to light intensities received at different wavelengths of the light source when the beam of light is directed at a particular X-Y plane location, the light intensities including information about a light reflectance distribution within an object in a depth direction Z at the particular X-Y plane location. A set of outputs generated from directing the beam of light at a particular X-Y plane location is high-pass filtered to generate a set of filtered outputs suitable for generating a two-dimensional image intensity map of the object.

摘要翻译： 提供了生成光学相干断层成像强度图的方法。 沿着采样路径和参考路径产生并分割光束。 样品路径光束被引导到X-Y平面中的位置。 从每个采样路径和参考路径返回的光被接收。 产生一组输出，每个输出对应于当光束指向特定XY平面位置时在光源的不同波长处接收的光强度，光强度包括关于物体内的光反射率分布在深度方向上的信息 Z在特定的XY平面位置。 通过在特定X-Y平面位置处引导光束产生的一组输出被高通滤波，以产生适合于生成对象的二维图像强度图的一组滤波输出。