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62 条记录 (耗时 0.029 秒)

    Serotonin and norepinephrine reuptake inhibitor and uses thereof
    4.
    发明授权
    Serotonin and norepinephrine reuptake inhibitor and uses thereof 失效
    5-羟色胺和去甲肾上腺素再摄取抑制剂及其应用

    公开(公告)号：US07595340B2

    公开(公告)日：2009-09-29

    申请号：US11486336

    申请日：2006-07-13

    申请人： Syed M. Shah ,  Mahdi B. Fawzi ,  Eric C. Ehrnsperger ,  Panolil Raveendranath

    发明人： Syed M. Shah ,  Mahdi B. Fawzi ,  Eric C. Ehrnsperger ,  Panolil Raveendranath

    IPC分类号： A61K31/35 ,  C07D309/10

    CPC分类号： C07D309/10 ,  A61K9/20 ,  A61K9/48

    摘要： Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agoraphobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.

    摘要翻译： 提供选择性双重5-羟色胺和去甲肾上腺素再摄取抑制剂。 这些化合物具有较低的副作用特征，并且可用于治疗各种病症的组合物和产品，包括抑郁症，纤维肌痛，焦虑症，惊恐障碍，广场恐怖症，创伤后应激障碍，经前期焦虑障碍，注意力缺陷障碍， 强迫症，社会焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，杜氏综合征，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍，边缘性人格障碍，纤维肌痛综合征，糖尿病性神经病变 疼痛，慢性疲劳综合征，疼痛，Shie Drager综合征，雷诺综合征，帕金森病和癫痫。

    Serotonin and norepinephrine reuptake inhibitors and uses thereof
    5.
    发明授权
    Serotonin and norepinephrine reuptake inhibitors and uses thereof 失效
    5-羟色胺和去甲肾上腺素再摄取抑制剂及其用途

    公开(公告)号：US07687520B2

    公开(公告)日：2010-03-30

    申请号：US11485693

    申请日：2006-07-13

    申请人： Syed M. Shah ,  Mahdi B. Fawzi ,  Panolil Raveendranath ,  Eric C. Ehrnsperger

    发明人： Syed M. Shah ,  Mahdi B. Fawzi ,  Panolil Raveendranath ,  Eric C. Ehrnsperger

    IPC分类号： A61K31/445 ,  C07D211/44

    CPC分类号： C07D211/44

    摘要： Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agorophobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.

    摘要翻译： 提供选择性双重5-羟色胺和去甲肾上腺素再摄取抑制剂。 这些化合物具有较低的副作用特征，并且可用于治疗各种病症的组合物和产品，包括抑郁症，纤维肌痛，焦虑症，惊恐障碍，广泛性恐惧症，创伤后应激障碍，经前焦虑障碍，注意力缺陷障碍， 强迫症，社会焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，杜氏综合征，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍，边缘性人格障碍，纤维肌痛综合征，糖尿病性神经病变 疼痛，慢性疲劳综合征，疼痛，Shie Drager综合征，雷诺综合征，帕金森病和癫痫。

    Rapamycin 29-enols
    7.
    发明授权
    Rapamycin 29-enols 失效
    雷帕霉素29-烯醇

    公开(公告)号：US06677357B2

    公开(公告)日：2004-01-13

    申请号：US10224971

    申请日：2002-08-22

    申请人： Tianmin Zhu ,  Mahdi B. Fawzi

    发明人： Tianmin Zhu ,  Mahdi B. Fawzi

    IPC分类号： A61K31445

    CPC分类号： C07D405/06 ,  C07D493/08

    摘要： This invention provides non-immunosuppressive rapamycin 29-enols, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.

    摘要翻译： 本发明提供了用于治疗实体瘤和血管疾病的非免疫抑制雷帕霉素29-烯醇，其可用作神经营养剂。