公开(公告)号：US5612325A

公开(公告)日：1997-03-18

申请号：US367206

申请日：1995-01-03

申请人： Kai Hansen ,  Henrik Pedersen

发明人： Kai Hansen ,  Henrik Pedersen

IPC分类号： A61K31/59 ,  A61K31/593 ,  A61P3/08 ,  A61P9/12 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C401/00

CPC分类号： C07C401/00

摘要： A compound of formula I ##STR1## wherein R stands for a straight or branched, saturated or unsaturated alkyl group containing from 4 to 12 carbon atoms optionally substituted with a hydroxy group, and possibly containing a ring structure, and in which at least one of the carbon atoms not bearing hydroxyl group is substituted with one or more halogen atoms or an azido group; and prodrugs of I in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo, in pure form or in mixtures. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. The compounds are prepared by oxidizing 1(S),3(R)-bis-(tert-butyldimethylsilyloxy)-20(S)formyl-9,10-seco-pregna-5(E),7(E),10(19)-triene, reducing the resulting product; alkylating the reduction product and then subjecting the alkylated product to triplet-sensitized photoisomerization.

摘要翻译： PCT No.PCT / DK95 / 00305 Sec。 371日期1995年1月3日 102（e）日期1995年1月3日PCT 1993年9月23日PCT公布。 第WO94 / 07851号公报 日期1994年04月14日一种式I化合物其中R代表任选被羟基取代的含有4至12个碳原子的直链或支链饱和或不饱和烷基，并且可能含有环结构， 其中至少一个不含羟基的碳原子被一个或多个卤素原子或叠氮基取代; 和其中一个或多个羟基被掩蔽为可以在体内，纯形式或混合物中再转化为羟基的基团的I前药。 这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。 通过氧化1（S），3（R） - 双 - （叔丁基二甲基甲硅烷氧基）-20（S）甲酰基-9,10-仲孕-5（E），7（E），10（ 19） - 三烯，还原所得产物; 烷基化还原产物，然后使烷基化产物进行三重敏感的光异构化。

公开(公告)号：US5589471A

公开(公告)日：1996-12-31

申请号：US362550

申请日：1995-01-03

申请人： Kai Hansen ,  Claus Aage S. Bretting

发明人： Kai Hansen ,  Claus Aage S. Bretting

IPC分类号： A61K31/59 ,  A61K31/593 ,  A61P3/08 ,  A61P9/12 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C401/00

CPC分类号： C07C401/00

摘要： Compounds of formula ##STR1## wherein Q is a --CH.sub.2 --, --CH.dbd.CH-- or --C.dbd.C--; U is a C.sub.1 -C.sub.6 alkylene; R.sup.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or YR' in which Y stands for the radicals --SO-- or --SO.sub.2 -- and R' stands for a C.sub.1 -C.sub.4 alkyl; R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1 -C.sub.4 alkyl, and additionally R.sup.2 and R.sup.3, when taken together with the starred carbon atom, may form a C.sub.3 -C.sub.6 carbocyclic ring; Z is hydrogen or hydroxy; and derivatives thereof. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. The compounds are prepared by adding an anion R.sup.- to 1(S),1(R)-bis-(tert-butyldimethylsilyl-oxy)-9,10-secopregna-5(E),7(E),10(19)-triene-20-one and the resulting compound is alkylated or acylated with R.sup.1 X.sup.1 where X.sup.1 is a leaving group followed by triplet-sensitized photoisomerization and deprotection to give the compound of formula I.

摘要翻译： PCT No.PCT / DK93 / 00311 Sec。 371日期1995年1月3日 102（e）日期1995年1月3日PCT 1993年9月27日PCT公布。 公开号WO94 / 07842 日期：1994年4月14日其中Q为-CH 2 - ， - CH = CH-或-C = C-的式 U是C1-C6亚烷基; R1是氢，C1-C4烷基或YR'，其中Y代表基团-SO-或-SO2-，R'代表C1-C4烷基; R2和R3独立地是氢或C1-C4烷基，另外当与星形碳原子一起时，R 2和R 3可以形成C 3 -C 6碳环; Z是氢或羟基; 及其衍生物。 这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。 通过加入阴离子R-至1（S），1（R） - 双 - （叔丁基二甲基甲硅烷氧基）-9,10-断孕甾-5（E），7（E），10 ） - 三烯-20-酮，所得化合物用R1X1烷基化或酰化，其中X1是离去基团，然后进行三重敏感的光异构化和去保护，得到式I化合物。

公开(公告)号：US5401732A

公开(公告)日：1995-03-28

申请号：US16186

申请日：1993-02-11

申请人： Martin J. Calverley ,  Kai Hansen ,  Lise Binderup

发明人： Martin J. Calverley ,  Kai Hansen ,  Lise Binderup

IPC分类号： C07C401/00

CPC分类号： C07C401/00

摘要： (I) The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into -O-acyl or -O-glycosyl or phosphate ester groups, such masked groups being hydrolyzable in vivo, in pure form or in mixtures. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus, hypertension, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.

摘要翻译： （I）本发明涉及式（I）化合物，其中式R代表任选被羟基取代的含有7至12个碳原子的烷基; 和其中一个或多个羟基已被转化成-O-酰基或-O-糖基或磷酸酯基团的式（I）化合物的衍生物，这些掩蔽基团在体内可水解，纯形式或混合物。 本发明化合物在人和兽医学实践中都可用于治疗和预防自身免疫疾病，包括糖尿病，高血压，诸如类风湿性关节炎和哮喘的炎性疾病以及以异常细胞分化和/或细胞增殖为特征的疾病， 和/或免疫系统的不平衡。

公开(公告)号：US4379274A

公开(公告)日：1983-04-05

申请号：US290649

申请日：1981-08-07

申请人： Kai Hansen

发明人： Kai Hansen

IPC分类号： H03H9/02 ,  H03H9/145 ,  H03H9/64 ,  H03H9/72

CPC分类号： H03H9/72 ,  H03H9/02842 ,  H03H9/1452 ,  H03H9/14544 ,  H03H9/02637

摘要： An acoustic surface wave filter is described for receiving one of two electrical signals at either of a pair of input ports and for providing a filtered electrical signal at a common output port. The filter includes a pair of input electro-acoustic transducers on a substrate, each coupled to one of the input ports, for launching surface waves in response to an electrical input signal. Each of the input transducers is associated with a multistrip coupler and an output transducer for converting the surface waves to an electrical output signal. The layout and geometry of the filter components are such that all surface waves are launched in a direction which is oblique to the substrate boundaries to reduce interference due to reflected surface waves. The layout and geometry also result in a relatively small substrate and a simultaneous reduction of insertion loss.

摘要翻译： 描述了用于在一对输入端口中的任一个处接收两个电信号中的一个并且用于在公共输出端口处提供经滤波的电信号的声表面波滤波器。 滤波器包括在基板上的一对输入电声换能器，每一个耦合到一个输入端口，用于响应于电输入信号发射表面波。 每个输入换能器与多波束耦合器和用于将表面波转换成电输出信号的输出换能器相关联。 滤波器部件的布局和几何形状使得所有表面波沿着与基板边界倾斜的方向发射，以减少由于反射的表面波引起的干扰。 布局和几何形状也导致相对较小的基板和同时减小的插入损耗。

公开(公告)号：US08639799B2

公开(公告)日：2014-01-28

申请号：US12505768

申请日：2009-07-20

申请人： Kai Hansen ,  Marius-Petru Stanica ,  Esther Gelle

发明人： Kai Hansen ,  Marius-Petru Stanica ,  Esther Gelle

IPC分类号： G06F15/173

CPC分类号： G05B23/0224 ,  G05B23/0275 ,  G05B2219/31211 ,  G05B2219/31359 ,  Y02P90/14 ,  Y02P90/18 ,  Y02P90/22

摘要： Supervision of industrial plants can be improved by comparison and analysis of process information and network information. The comparison may be used to provide alarms and operator information for network-related or process device failures. The information may also be used to identify a cause of a failure. A method is described for supervising an industrial control system, including a plant network for supervision, a client/server network for server connection with workstations, and a control network connected to industrial controllers. The method comprises the steps of gathering process information, and gathering network information, and by comparing information provided by data communications network monitoring with process control information and using the result of the comparison to assist in determining a cause of a problem or possible problem in a process controlled of the industrial control system.

摘要翻译： 通过比较和分析过程信息和网络信息可以提高工业厂房的监督。 该比较可用于为网络相关或过程设备故障提供报警和操作员信息。 该信息也可用于识别失败的原因。 描述了一种用于监督工业控制系统的方法，包括用于监视的工厂网络，用于与工作站的服务器连接的客户端/服务器网络，以及连接到工业控制器的控制网络。 该方法包括收集过程信息和收集网络信息的步骤，以及将数据通信网络监控提供的信息与过程控制信息进行比较，并使用比较结果来帮助确定问题的原因或可能出现的问题 过程控制的工业控制系统。

公开(公告)号：US20100016994A1

公开(公告)日：2010-01-21

申请号：US12505768

申请日：2009-07-20

申请人： Kai Hansen ,  Marius-Petru Stanica ,  Esther Gelle

发明人： Kai Hansen ,  Marius-Petru Stanica ,  Esther Gelle

IPC分类号： G05B19/418 ,  G05B9/02 ,  G05B15/00

CPC分类号： G05B23/0224 ,  G05B23/0275 ,  G05B2219/31211 ,  G05B2219/31359 ,  Y02P90/14 ,  Y02P90/18 ,  Y02P90/22

摘要： Supervision of industrial plants can be improved by comparison and analysis of process information and network information. The comparison may be used to provide alarms and operator information for network-related or process device failures. The information may also be used to identify a cause of a failure. A method is described for supervising an industrial control system, including a plant network for supervision, a client/server network for server connection with workstations, and a control network connected to industrial controllers. The method comprises the steps of gathering process information, and gathering network information, and by comparing information provided by data communications network monitoring with process control information and using the result of the comparison to assist in determining a cause of a problem or possible problem in a process controlled of the industrial control system.

摘要翻译： 通过比较和分析过程信息和网络信息可以提高工业厂房的监督。 该比较可用于为网络相关或过程设备故障提供报警和操作员信息。 该信息也可用于识别失败的原因。 描述了一种用于监督工业控制系统的方法，包括用于监视的工厂网络，用于与工作站的服务器连接的客户端/服务器网络，以及连接到工业控制器的控制网络。 该方法包括收集过程信息和收集网络信息的步骤，以及将数据通信网络监控提供的信息与过程控制信息进行比较，并使用比较结果来帮助确定问题的原因或可能出现的问题 过程控制的工业控制系统。

公开(公告)号：US5378695A

公开(公告)日：1995-01-03

申请号：US62154

申请日：1993-05-17

申请人： Martin J. Calverley ,  Kai Hansen ,  Lise Binderup

发明人： Martin J. Calverley ,  Kai Hansen ,  Lise Binderup

IPC分类号： C07C401/00 ,  C07F7/18 ,  C07F9/117

CPC分类号： C07F7/1864 ,  C07C401/00 ,  C07F7/1856 ,  C07F9/117

摘要： ##STR1## The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into --O-acyl or --O-glycosyl or phosphate ester groups, such masked groups being hydrolyzable in vivo, in pure form or in mixtures. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus, hypertension, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.

公开(公告)号：US4764701A

公开(公告)日：1988-08-16

申请号：US947655

申请日：1986-12-30

申请人： Michael J. Garbacz ,  Kai Hansen

发明人： Michael J. Garbacz ,  Kai Hansen

IPC分类号： H03H9/145 ,  H04N7/167 ,  H01L41/08

CPC分类号： H03H9/72 ,  H03H9/02779 ,  H03H9/14567 ,  H04N7/167 ,  H03H9/1452 ,  H03H9/14547 ,  H03H9/1455 ,  H03H9/14552

摘要： A multichannel surface acoustic wave encoder/decoder having a common electrical input is designed so that the insertion losses of the channels differ despite the apparent design constraint of closely matched channel output impedances. The input transducing device or SAW transmitter is divided into individual transducers (or into subtransducers) having different numbers of finger overlaps, thus achieving different acoustic output levels which in turn result in different insertion losses for different channels. The finger spacing of the SAW transmitters can differ between the respective input transducers or subtransducers so as to optimize the center frequency of each channel.

摘要翻译： 设计具有公共电输入的多声道表面声波编码器/解码器，尽管存在紧密匹配的通道输出阻抗的明显设计约束，但是通道的插入损耗也是相同的。 输入转换装置或SAW发射器被分成具有不同数量的手指重叠的单个换能器（或者变换器），从而实现不同的声输出电平，这又导致不同通道的插入损耗不同。 SAW发射器的手指间距可以在相应的输入换能器或副传感器之间不同，以便优化每个通道的中心频率。

公开(公告)号：US08515562B2

公开(公告)日：2013-08-20

申请号：US11976386

申请日：2007-10-24

申请人： Kai Hansen

发明人： Kai Hansen

IPC分类号： G05B15/02 ,  G06F19/00 ,  G06F17/50

CPC分类号： G05B19/054 ,  G05B2219/13174 ,  G05B2219/13184 ,  G05B2219/23456

摘要： A computer based control system including a field network to which field devices equipped with hardware addresses and logical names are to be connected, a control device performing addressing control in relation to the field devices and their logical addresses and a simulation handling device. The simulation handling device has an own logical address, an own hardware address and is capable of obtaining a logical address, as well as possibly a logical name and/or a hardware address of at least one field device involved in the simulation. It notifies the control device that the field device is connected to the field network, detects a control signal directed towards field device addressed using the logical and/or hardware address of this field device and responds to the control signal with simulation results using the same logical and/or hardware address as the source of the response.

摘要翻译： 一种基于计算机的控制系统，包括要连接配备有硬件地址和逻辑名称的现场设备的现场网络，执行与现场设备及其逻辑地址相关的寻址控制的控制设备和模拟处理设备。 仿真处理设备具有自己的逻辑地址，自己的硬件地址，并且能够获得逻辑地址，以及可能的逻辑名称和/或模拟中涉及的至少一个现场设备的硬件地址。 它通知控制设备现场设备连接到现场网络，检测使用该现场设备的逻辑和/或硬件地址寻址的现场设备的控制信号，并使用相同的逻辑对模拟结果进行响应控制信号 和/或硬件地址作为响应的源。

公开(公告)号：US20060101433A1

公开(公告)日：2006-05-11

申请号：US10519151

申请日：2003-06-27

申请人： Audun Opem ,  Mats Gunnmarker ,  Kai Hansen

发明人： Audun Opem ,  Mats Gunnmarker ,  Kai Hansen

IPC分类号： G06F9/44

CPC分类号： G06F11/3688 ,  G06F8/41

摘要： A method to revalidate a compiler intended for compilation of a user-written program for safety control in an industrial control system after it has been used. A test program is compiled a first time which test program is defined in a control language. The compiler is validated by verifying that the test program executes correctly. A first software is generated derived from the compiled test program intended for later comparison purposes. The test program is compiled a second time after the compilation of a user-written program. A second software is generated intended for a comparison based on the second compilation of the test program. The first software is compared with the second software, wherein the compiler is revalidated for any errors introduced between the first and the second compilation. Provided that the revalidation indicates no errors in the compiler, the user-written program is enabled to execute in a device with safety features for control of real world entities.

摘要翻译： 一种用于在工业控制系统使用之后，为了编译用于安全控制的用户编写程序而编译的编译器的方法。 第一次编译测试程序，该测试程序以控制语言定义。 编译器通过验证测试程序是否正确执行来验证。 从编译的测试程序生成的第一个软件是为了进行以后的比较而产生的。 测试程序在编译用户编写的程序后第二次编译。 生成第二个软件，用于基于测试程序的第二次编译进行比较。 将第一个软件与第二个软件进行比较，其中对于在第一个和第二个编译之间引入的任何错误，编译器被重新验证。 如果重新验证指示编译器没有错误，则用户编写的程序能够在具有用于控制真实世界实体的安全功能的设备中执行。