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    Cardiac Glycosides for Treating Autoimmune Disease
    1.
    发明申请
    Cardiac Glycosides for Treating Autoimmune Disease 审中-公开
    用于治疗自身免疫性疾病的心脏糖苷

    公开(公告)号：US20140011755A1

    公开(公告)日：2014-01-09

    申请号：US13992182

    申请日：2011-12-13

    申请人： Emily A. Stein ,  William H. Robinson ,  Ricardo T. Paniagua

    发明人： Emily A. Stein ,  William H. Robinson ,  Ricardo T. Paniagua

    IPC分类号： A61K31/7048 ,  A61K31/585

    CPC分类号： A61K31/7048 ,  A61K31/585

    摘要： The invention provides methods for treating inflammatory and autoimmune diseases by administering to the subject an effective amount of a cardiac glycoside, where the dose is effective to suppress or prevent initiation, progression, or relapses of the disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject determined to have rheumatoid arthritis or systemic lupus, or a pre-clinical disease state thereof, an effective amount of a cardiac glycoside, to suppress or prevent activity of the disease. In other embodiments, the methods of the invention comprise administering to a subject determined to have insufficient endogenous cardiac glycosides, an effective amount as a supplement to counteract the effects of cardiac glycoside deficiency.

    摘要翻译： 本发明提供了通过向受试者施用有效量的心脏糖苷来治疗炎性和自身免疫疾病的方法，其中剂量有效地抑制或预防疾病的起始，进展或复发，包括已确立疾病的进展。 在一些实施方案中，本发明的方法包括给予确定具有类风湿性关节炎或系统性红斑狼疮或其临床前疾病状态有效量的强心苷抑制或预防疾病活性的对象。 在其它实施方案中，本发明的方法包括对被确定具有不足的内源性强心苷的受试者施用有效量作为补充以抵抗强心苷缺乏症的作用。

    Therapeutic and diagnostic uses of antibody specificity profiles
    4.
    发明授权
    Therapeutic and diagnostic uses of antibody specificity profiles 有权
    抗体特异性谱的治疗和诊断用途

    公开(公告)号：US07785819B2

    公开(公告)日：2010-08-31

    申请号：US10120578

    申请日：2002-04-10

    申请人： William H. Robinson ,  David L. Hirschberg ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz ,  Hideki Garren

    发明人： William H. Robinson ,  David L. Hirschberg ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz ,  Hideki Garren

    IPC分类号： G01N33/00

    CPC分类号： A61K39/0008 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/102 ,  G01N2800/24 ,  G01N2800/52

    摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.

    摘要翻译： 本发明提供了确定个体中抗体特异性谱的方法。 该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。 阵列可以包括抗原和表位。 本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。

    Killing insect pests inside wood by vacuum dehydration
    6.
    发明授权
    Killing insect pests inside wood by vacuum dehydration 失效
    通过真空脱水杀死木材内的昆虫害虫

    公开(公告)号：US07739829B2

    公开(公告)日：2010-06-22

    申请号：US11574551

    申请日：2005-07-11

    申请人： Zhangjing Chen ,  Marshall S. White ,  William H. Robinson

    发明人： Zhangjing Chen ,  Marshall S. White ,  William H. Robinson

    IPC分类号： A01M1/20 ,  F26B5/04 ,  F26B3/20

    CPC分类号： A01N25/00 ,  A01M1/2094 ,  A01M13/003 ,  F26B5/04 ,  F26B9/006 ,  F26B2210/16

    摘要： Insect pests can be transported around the world in wooden shipping containers. To prevent the spread of wood-borne insect pests, it is necessary to kill insects within the wood. The wood is placed in a vacuum container having a flexible wall. The flexible wall presses against the wood and enables the wood to be heated by conduction. The wood and flexible wall can to be heated by contact with ambient or heated air, for example. Desiccant or dry air can be used to increase the rate of dehydration. Insects in the wood are typically killed after losing 25-50% of their body weight by dehydration. This technique will kill beetle larvae, nematodes and other invasive and destructive insects that live inside solid wood, and is particularly applicable for rendering wood acceptable for use in pallets and other containers shipped internationally.

    摘要翻译： 昆虫害虫可以运送到世界各地的木制运输集装箱。 为了防止木质虫害的蔓延，有必要杀死木材内的昆虫。 将木材放置在具有柔性壁的真空容器中。 柔性壁压在木材上，使木材能够被传导加热。 例如，木材和柔性壁可以通过与环境或加热的空气接触而被加热。 干燥剂或干燥空气可用于提高脱水率。 木材中的昆虫通常脱水失去体重的25-50％之后就会死亡。 这种技术将杀死住实木内的甲虫幼虫，线虫和其他侵入性和破坏性的昆虫，特别适用于木材可接受用于国际运输的托盘和其他容器。

    COMPLEMENT INHIBITORY AGENTS AS THERAPEUTICS IN POSTTRAUMATIC AND DEGENERATIVE ARTHRITIS
    7.
    发明申请
    COMPLEMENT INHIBITORY AGENTS AS THERAPEUTICS IN POSTTRAUMATIC AND DEGENERATIVE ARTHRITIS 审中-公开
    补充抑制剂作为治疗和减退性ARTHRITIS治疗药物

    公开(公告)号：US20090324585A1

    公开(公告)日：2009-12-31

    申请号：US12482703

    申请日：2009-06-11

    申请人： William H. Robinson ,  V. Michael Holers ,  Andrew L. Rozelle

    发明人： William H. Robinson ,  V. Michael Holers ,  Andrew L. Rozelle

    IPC分类号： A61K39/395 ,  A61K38/00

    CPC分类号： A61K38/17 ,  A01K67/0278 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0368 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/18

    摘要： The present disclosure is directed to methods and compositions for treating osteoarthritis and preventing osteoarthritis, by administering a compound that modulates one or more components in the complement system. In one embodiment, a compound that inhibits a component in the complement system is administered to prevent, delay the progression of, or treat osteoarthritis. In other embodiments, compounds with specific inhibition of a component in a particular pathway in the complement system, such as the alternative, mannose binding lectin, and/or classical pathway, are administered to a subject having osteoarthritis or at risk of developing osteoarthritis.

    摘要翻译： 本公开涉及通过施用调节补体系统中的一种或多种组分的化合物来治疗骨关节炎和预防骨关节炎的方法和组合物。 在一个实施方案中，施用抑制补体系统中的成分的化合物以预防，延缓进展或治疗骨关节炎。 在其它实施方案中，对具有骨关节炎或有发展为骨关节炎风险的受试者施用对补体系统中特定途径中的组分具有特异性抑制的化合物，例如替代性甘露糖结合凝集素和/或经典途径。

    POLYNUCLEOTIDE THERAPY
    8.
    发明申请
    POLYNUCLEOTIDE THERAPY 审中-公开
    多核苷酸治疗

    公开(公告)号：US20090264515A1

    公开(公告)日：2009-10-22

    申请号：US12467866

    申请日：2009-05-18

    申请人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

    发明人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

    IPC分类号： A61K31/7088 ,  A61P21/00

    CPC分类号： A61K39/001 ,  A61K38/2026 ,  A61K39/0007 ,  A61K39/0008 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55561 ,  C07K2319/30

    摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.

    摘要翻译： 本发明提供了一种治疗或预​​防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法， 所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。 施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答 （s）表示自我向量的管理。 本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病 其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

    Alpha b-chrystallin as a therapy for inflammation
    10.
    发明申请
    Alpha b-chrystallin as a therapy for inflammation 有权
    αb-chrystallin作为炎症治疗

    公开(公告)号：US20080138353A1

    公开(公告)日：2008-06-12

    申请号：US12001553

    申请日：2007-12-11

    申请人： Lawrence Steinman ,  Shalina Sheryl Ousman ,  William H. Robinson

    发明人： Lawrence Steinman ,  Shalina Sheryl Ousman ,  William H. Robinson

    IPC分类号： A61K39/395 ,  A61K31/711 ,  A61K38/16 ,  A61P29/00 ,  A61P37/00 ,  A61P25/00 ,  A61P21/00 ,  A61P25/28

    CPC分类号： A61K31/711 ,  A61K38/1709

    摘要： The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject having a pre-existing inflammatory disease condition, an effective amount of alpha B-crystallin protein, to suppress or prevent relapses of the disease.

    摘要翻译： 本发明提供了通过向受试者施用有效量的提供αB-晶状蛋白活性的药剂来治疗炎性疾病的方法，其中剂量有效地抑制或预防疾病的起始，进展或复发，包括已建立的 疾病。 在一些实施方案中，本发明的方法包括向具有预先存在的炎症疾病状况的受试者施用有效量的α-B-晶状蛋白，以抑制或预防疾病的复发。