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公开(公告)号：US11913834B2
公开(公告)日：2024-02-27
申请号：US17402798
申请日：2021-08-16
发明人： James M. Tedesco , Sean J. Gilliam
CPC分类号： G01J3/0243 , G01J3/0208 , G01J3/0218 , G01J3/12 , G01J3/44 , G02B6/04 , G01J2003/1213
摘要： An optical measurement probe for capturing a spectral response through an intervening material emitting unwanted background radiation includes: a first lens configured to receive light and collimate the light into a collimated excitation beam defining a first aperture; an objective element for focusing the collimated excitation beam to a point or region in a sample through the intervening material, wherein the objective element also receives light scattered by the sample and the intervening material and collimates the scattered light into a collimated collection beam defining a second aperture; and a blocking element within the collimated collection beam for removing the light scattered by the intervening material from the collimated collection beam received from the sample, wherein the second aperture defined by the collimated collection beam is at least two times greater than the first aperture defined by the collimated excitation beam.
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公开(公告)号：US20230048375A1
公开(公告)日：2023-02-16
申请号：US17402798
申请日：2021-08-16
发明人： James M. Tedesco , Sean J. Gilliam
摘要： An optical measurement probe for capturing a spectral response through an intervening material emitting unwanted background radiation includes: a first lens configured to receive light and collimate the light into a collimated excitation beam defining a first aperture; an objective element for focusing the collimated excitation beam to a point or region in a sample through the intervening material, wherein the objective element also receives light scattered by the sample and the intervening material and collimates the scattered light into a collimated collection beam defining a second aperture; and a blocking element within the collimated collection beam for removing the light scattered by the intervening material from the collimated collection beam received from the sample, wherein the second aperture defined by the collimated collection beam is at least two times greater than the first aperture defined by the collimated excitation beam.
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3.发明申请公开(公告)号：US20210372932A1
公开(公告)日：2021-12-02
申请号：US17405536
申请日：2021-08-18
发明人： Sean J. Gilliam
摘要： A method of characterizing and monitoring a pressing process includes acquiring online Raman spectra of a juice pressing process within a vessel at different times during the pressing process to generate a training data set; acquiring physical samples from pressing process near in time to the acquired Raman spectra; performing offline measurements of the target analyte properties and/or compositions using an assay measurement technique; generating a correlative model of the target analyte such that spectral changes in the training data set correlate with the offline measurements of the target analyte properties and/or compositions; acquiring online Raman spectra of a subsequent run of the pressing process within the vessel at different times during the run to generate a process data set; and applying the correlative model to the process data set to qualitatively and/or quantitatively predict a value of a property and/or composition of the target analyte.
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公开(公告)号：US11231324B2
公开(公告)日：2022-01-25
申请号：US17174949
申请日：2021-02-12
发明人： Sean J. Gilliam
摘要： A method of characterizing and monitoring a fermentation process includes acquiring online Raman spectra of a fermentation process within a fermenter vessel at different times during the fermentation process to generate a training data set; acquiring physical samples from fermentation process near in time to the acquired Raman spectra; performing offline measurements of the target analyte properties and/or compositions using an assay measurement technique; generating a correlative model of the target analyte such that spectral changes in the training data set correlate with the offline measurements of the target analyte properties and/or compositions; acquiring online Raman spectra of a subsequent run of the fermentation process within the fermenter vessel at different times during the run to generate a process data set; and applying the correlative model to the process data set to qualitatively and/or quantitatively predict a value of a property and/or composition of the target analyte.
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公开(公告)号：US20210255040A1
公开(公告)日：2021-08-19
申请号：US17174949
申请日：2021-02-12
发明人： Sean J. Gilliam
摘要： A method of characterizing and monitoring a fermentation process includes acquiring online Raman spectra of a fermentation process within a fermenter vessel at different times during the fermentation process to generate a training data set; acquiring physical samples from fermentation process near in time to the acquired Raman spectra; performing offline measurements of the target analyte properties and/or compositions using an assay measurement technique; generating a correlative model of the target analyte such that spectral changes in the training data set correlate with the offline measurements of the target analyte properties and/or compositions; acquiring online Raman spectra of a subsequent run of the fermentation process within the fermenter vessel at different times during the run to generate a process data set; and applying the correlative model to the process data set to qualitatively and/or quantitatively predict a value of a property and/or composition of the target analyte.
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公开(公告)号：US10365229B2
公开(公告)日：2019-07-30
申请号：US14986260
申请日：2015-12-31
发明人： Sean J. Gilliam
摘要： Pharmaceutical tablet properties, including surface roughness, gloss and temperature, are determined in real-time using Raman spectroscopy. A plurality of coated pharmaceutical tablets are provided having a distribution of known values of a surface property to be modeled. The Raman spectrum of each coated tablet is acquired to generate a distribution of Raman spectra. A correlative model is then developed based upon the distribution of the acquired Raman spectra relative to the distribution of the known values of the measured property. The Raman spectrum of a pharmaceutical tablet is then acquired during and/or after a coating process, and the value of the surface property of the tablet is determined using the correlative model. The steps associated with model development are carried out off-line, whereas the step or steps associated with acquiring the Raman spectra of the pharmaceutical tablet during (preferable) or after online coating process(es) are carried out on-line using a remote, fiber-coupled probe.
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公开(公告)号：US20170191947A1
公开(公告)日：2017-07-06
申请号：US14986260
申请日：2015-12-31
发明人： Sean J. Gilliam
CPC分类号： G01N21/9508 , A61J3/005 , A61K9/28 , A61K9/2893 , G01N21/57 , G01N21/65 , G01N21/8422 , G01N21/8851 , G01N33/15
摘要： Pharmaceutical tablet properties, including surface roughness, gloss and temperature, are determined in real-time using Raman spectroscopy. A plurality of coated pharmaceutical tablets are provided having a distribution of known values of a surface property to be modeled. The Raman spectrum of each coated tablet is acquired to generate a distribution of Raman spectra. A correlative model is then developed based upon the distribution of the acquired Raman spectra relative to the distribution of the known values of the measured property. The Raman spectrum of a pharmaceutical tablet is then acquired during and/or after a coating process, and the value of the surface property of the tablet is determined using the correlative model. The steps associated with model development are carried out off-line, whereas the step or steps associated with acquiring the Raman spectra of the pharmaceutical tablet during (preferable) or after online coating process(es) are carried out on-line using a remote, fiber-coupled probe.
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