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    DRUG DELIVERY SYSTEMS
    1.
    发明申请
    DRUG DELIVERY SYSTEMS 审中-公开
    药物递送系统

    公开(公告)号：US20100185146A1

    公开(公告)日：2010-07-22

    申请号：US12580162

    申请日：2009-10-15

    申请人： Kamal RAMZIPOOR ,  Ary CHERNOMORSKY

    发明人： Kamal RAMZIPOOR ,  Ary CHERNOMORSKY

    IPC分类号： A61M25/10

    CPC分类号： A61M25/10 ,  A61M2025/105

    摘要： Drug delivery systems which are configured to retain and then distribute one or more drugs upon an actuating surface and/or balloon for delivery to a tissue region are described herein. The drug delivery system may comprise in one variation a volume of one or more drugs held in a reservoir, e.g., a silo, which may be located proximally of the expandable actuating surface and/or balloon. The one or more drugs may be separated from one another by valves or immiscible fluid barriers for distribution upon the surface, which may be varied in pore distribution, have a coating or covering for facilitating drug distribution, etc.

    摘要翻译： 这里描述了被配置为保持并随后将一种或多种药物分配在致动表面和/或球囊上以递送至组织区域的药物递送系统。 药物递送系统可以在一个变体中包括一个或多个药物的体积，其保持在储存器例如筒仓中，储存器可位于可膨胀致动表面和/或气囊的近侧。 一种或多种药物可以通过阀或不混溶的流体屏障彼此分离，用于分布在表面上，其可以在孔分布中变化，具有用于促进药物分布的涂层或覆盖物等。

    DETECTION AND CHARACTERIZATION OF LASER-INDUCED HEAT AFFECTED ZONES ON POLYMER BASED DEVICES
    3.
    发明申请
    DETECTION AND CHARACTERIZATION OF LASER-INDUCED HEAT AFFECTED ZONES ON POLYMER BASED DEVICES 审中-公开
    基于聚合物的器件激光诱发热影响区域的检测与表征

    公开(公告)号：US20110302677A1

    公开(公告)日：2011-12-08

    申请号：US13152704

    申请日：2011-06-03

    申请人： Kamal RAMZIPOOR ,  Yiwen TANG

    发明人： Kamal RAMZIPOOR ,  Yiwen TANG

    IPC分类号： G01Q60/24

    CPC分类号： G01Q60/58 ,  G01Q60/02

    摘要： Detection and characterization of laser-induced heat affected zones on polymer based devices, such as polymeric stents, are described where Nano Thermal Analysis may be used with atomic force microscopy to obtain the thermal behavior of materials with a spatial resolution of under, e.g., 100 nm. Heat may be applied locally to the measured polymeric stem via a probe tip and the resulting thermal-mechanical response can be measured.

    摘要翻译： 描述了基于聚合物的装置（例如聚合物支架）上的激光诱导的热影响区域的检测和表征，其中可以使用原子力显微镜来进行纳米热分析以获得空间分辨率低于100的材料的热行为，例如100 nm。 可以通过探针尖端将热量局部施加到所测量的聚合物杆上，并且可以测量所得到的热 - 机械响应。

    COMPOSITE STENT HAVING MULTI-AXIAL FLEXIBILITY
    5.
    发明申请
    COMPOSITE STENT HAVING MULTI-AXIAL FLEXIBILITY 审中-公开
    具有多轴灵活性的复合材料

    公开(公告)号：US20100042202A1

    公开(公告)日：2010-02-18

    申请号：US12541095

    申请日：2009-08-13

    申请人： Kamal RAMZIPOOR ,  Richard J. SAUNDERS

    发明人： Kamal RAMZIPOOR ,  Richard J. SAUNDERS

    IPC分类号： A61F2/06 ,  B05D3/00 ,  B32B1/08

    CPC分类号： A61F2/91 ,  A61F2/07 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2210/0076 ,  Y10T428/139

    摘要： Composite stent structures having multi-axial flexibility are described where the composite stent may have one or more layers of bioabsorbable polymers fabricated with the desired characteristics for implantation within a vessel. A number of individual ring structures separated from one another may be encased between a base polymeric layer and an overlaid polymeric layer such that the rings are coupled to one another via elastomeric segments which enable the composite stent to flex axially and rotationally along with the vessel. Each layer may have a characteristic that individually provides a certain aspect of mechanical behavior to the composite stent such that the aggregate layers form a composite polymeric stent structure capable of withstanding complex, multi-axial loading conditions imparted by an anatomical environment such as the SFA.

    摘要翻译： 描述了具有多轴向柔性的复合支架结构，其中复合支架可以具有制造具有用于在血管内植入的期望特性的一层或多层生物可吸收聚合物。 彼此分离的多个单独的环结构可以被封装在基础聚合物层和覆盖的聚合物层之间，使得环通过弹性片段彼此耦合，这使得复合支架能够与容器一起轴向和旋转地弯曲。 每个层可以具有单独地向复合支架提供机械行为的某一方面的特征，使得聚集体层形成能够承受诸如SFA之类的解剖学环境赋予的复杂的多轴向负载条件的复合聚合物支架结构。

    STENT FABRICATION VIA TUBULAR CASTING PROCESSES
    6.
    发明申请
    STENT FABRICATION VIA TUBULAR CASTING PROCESSES 审中-公开
    通过管状铸造工艺制造的STENT制造

    公开(公告)号：US20120232643A1

    公开(公告)日：2012-09-13

    申请号：US13476853

    申请日：2012-05-21

    申请人： Kamal RAMZIPOOR ,  Alfred N. K. CHIA ,  Liwei WANG

    发明人： Kamal RAMZIPOOR ,  Alfred N. K. CHIA ,  Liwei WANG

    IPC分类号： A61F2/82

    CPC分类号： A61F2/82 ,  A61F2/07 ,  A61F2/24 ,  A61F2002/30062 ,  A61F2002/30535 ,  A61F2210/0004 ,  A61F2210/0019 ,  A61F2240/004 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  B29C41/003 ,  B29C41/14 ,  B29C49/00 ,  B29K2105/0035 ,  B29K2995/0056 ,  B29L2031/7532

    摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

    摘要翻译： 可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。 聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。 浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以 每个都被控制以产生期望的机械特性。 还可以使用额外的后处理来进一步增加基底的强度或改变其形状。

    STENT FABRICATION VIA TUBULAR CASTING PROCESSES
    7.
    发明申请
    STENT FABRICATION VIA TUBULAR CASTING PROCESSES 有权
    通过管状铸造工艺制造的STENT制造

    公开(公告)号：US20100004734A1

    公开(公告)日：2010-01-07

    申请号：US12488453

    申请日：2009-06-19

    申请人： Kamal RAMZIPOOR ,  Alfred N. K. CHIA ,  Liwei WANG ,  Chang Yeul Lee

    发明人： Kamal RAMZIPOOR ,  Alfred N. K. CHIA ,  Liwei WANG ,  Chang Yeul Lee

    IPC分类号： A61F2/06 ,  B05D1/18

    CPC分类号： B05D1/18 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2210/0076

    摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

    摘要翻译： 可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。 聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。 浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以 每个都被控制以产生期望的机械特性。 还可以使用额外的后处理来进一步增加基底的强度或改变其形状。