公开(公告)号：US08002789B2

公开(公告)日：2011-08-23

申请号：US11140691

申请日：2005-05-31

申请人： Kamal Ramzipoor ,  Like Que ,  Jimmy D. Dao ,  Esther Chang

发明人： Kamal Ramzipoor ,  Like Que ,  Jimmy D. Dao ,  Esther Chang

IPC分类号： A61F2/06

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/12154 ,  A61B2017/00004 ,  A61B2017/12054 ,  A61B2017/12063

摘要： Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices.

摘要翻译： 本文公开了用于形成阻塞患者脉管系统的血管闭塞装置。 更具体地，本文公开了包含至少一种聚合物结构的血管闭塞装置以及制造和使用这些装置的方法。

公开(公告)号：US20060271086A1

公开(公告)日：2006-11-30

申请号：US11140691

申请日：2005-05-31

申请人： Kamal Ramzipoor ,  Like Que ,  Jimmy Dao ,  Esther Chang

发明人： Kamal Ramzipoor ,  Like Que ,  Jimmy Dao ,  Esther Chang

IPC分类号： A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/12154 ,  A61B2017/00004 ,  A61B2017/12054 ,  A61B2017/12063

摘要： Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices.

摘要翻译： 本文公开了用于形成阻塞患者脉管系统的血管闭塞装置。 更具体地，本文公开了包含至少一种聚合物结构的血管闭塞装置以及制造和使用这些装置的方法。

公开(公告)号：US08834515B2

公开(公告)日：2014-09-16

申请号：US11942929

申请日：2007-11-20

申请人： Thazin Win ,  Like Que ,  Esther Chang ,  Ann Huang

发明人： Thazin Win ,  Like Que ,  Esther Chang ,  Ann Huang

IPC分类号： A61B17/00 ,  A61B17/12

CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B2017/0053 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12095 ,  Y10T29/49826

摘要： A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the locking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

摘要翻译： 用于传送闭塞元件的装置包括具有内腔的细长推动器构件。 锁定构件设置在细长推动构件的内腔内。 可移动的细长释放构件设置在细长推动构件的内腔内。 长丝被固定到细长释放构件的远端。 当细丝通过闭塞构件上的固定构件并且被夹紧或楔入锁定构件和细长释放构件之间时，闭塞构件被锁定到细长释放构件。 当细长释放构件相对于细长推动构件向近侧缩回时，闭塞元件处于未锁定状态。 长丝与细长的释放构件一起向近侧缩回，直到细丝与闭塞构件的固定构件分离或脱离。

公开(公告)号：US20080306503A1

公开(公告)日：2008-12-11

申请号：US11942913

申请日：2007-11-20

申请人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

发明人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

IPC分类号： A61M37/00

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B90/39 ,  A61B2017/12054

摘要： A device for delivering an occlusive element such as a vaso-occlusive coil includes an elongate sheath. An elongate releasing member having a distal tip or end is moveable within a lumen of the elongate sheath. A filament is provided having first and second ends with each end being fixed relative to the elongate sheath to form a loop segment. The loop segment of the filament is passed through a securing member located on the proximal end of the occlusive element. The distal tip of the elongate releasing member is inserted into the portion of the loop segment that passes through the securing member to lock the occlusive element relative to the elongate sheath. The occlusive element is released by pulling the elongate releasing member proximally to retract the distal tip from the loop segment of the filament.

摘要翻译： 用于输送闭塞元件例如血管闭塞线圈的装置包括细长护套。 具有远端尖端或端部的细长释放构件可在细长护套的内腔内移动。 提供具有第一和第二端部的长丝，每个端部相对于细长护套固定，以形成环形段。 细丝的环段通过位于闭塞元件的近端的固定构件。 细长释放构件的远侧末端插入到通过固定构件的环段的部分中，以相对于细长护套锁定闭塞元件。 闭合元件通过向近侧拉伸细长释放构件来释放，以使远端从细丝的环段缩回。

公开(公告)号：US08926650B2

公开(公告)日：2015-01-06

申请号：US11942890

申请日：2007-11-20

申请人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

发明人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

IPC分类号： A61M29/00 ,  A61B17/12 ,  A61B17/00

CPC分类号： A61B17/12145 ,  A61B17/12022 ,  A61B17/12113 ,  A61B2017/00477 ,  A61B2017/12054

摘要： A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releasably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

摘要翻译： 用于递送闭塞元件的装置包括细长的推动器构件，其具有在远端和近端之间延伸的内腔。 细长释放构件可滑动地设置在细长推动构件的内腔内。 保持构件设置在细长推动器构件的远端上，并且包括具有孔径的手指部分，其尺寸设置成容纳细长释放构件的远端。 提供诸如线圈的闭塞元件，并且包括位于其近端处的固定构件。 固定构件可释放地固定到保持构件的指状部分。 当细长释放构件设置在手指部分的孔中时，固定构件被固定到指状部分，并且当细长释放构件从手指部分的孔向近侧缩回时，固定构件被固定到指状部分。

公开(公告)号：US08956381B2

公开(公告)日：2015-02-17

申请号：US11942952

申请日：2007-11-20

申请人： Like Que ,  Ann Huang ,  Esther Chang ,  Thazin Win ,  Stella Chu

发明人： Like Que ,  Ann Huang ,  Esther Chang ,  Thazin Win ,  Stella Chu

IPC分类号： A61M29/00 ,  A61B17/12 ,  A61B17/00

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00477 ,  A61B2017/12054

摘要： A device for delivering an occlusive element includes an elongate sheath. A distal blocking member is located at the distal end of the elongate sheath and includes an aperture therein. An elongate releasing member is disposed within a lumen of the elongate sheath. The elongate releasing member includes a proximal end and a distal end with the distal end terminating in at least one retaining member. The device includes an occlusive element such as, for example, a vaso-occlusive coil that has a securing member located at a proximal end thereof. The securing member of the occlusive element passes through the aperture of the distal blocking member and the at least one retaining member is releasably secured to the securing member.

摘要翻译： 用于传送封闭元件的装置包括细长护套。 远端阻塞构件位于细长护套的远端并且在其中包括孔。 细长释放构件设置在细长护套的内腔内。 细长释放构件包括近端和远端，远端终止于至少一个保持构件。 该装置包括闭塞元件，例如具有位于其近端的固定构件的血管闭塞线圈。 闭塞元件的固定构件通过远端阻挡构件的孔，并且至少一个保持构件可释放地固定到固定构件。

公开(公告)号：US20080300616A1

公开(公告)日：2008-12-04

申请号：US11942890

申请日：2007-11-20

申请人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

发明人： Like Que ,  Esther Chang ,  Ann Huang ,  Thazin Win

IPC分类号： A61M29/00

CPC分类号： A61B17/12145 ,  A61B17/12022 ,  A61B17/12113 ,  A61B2017/00477 ,  A61B2017/12054

摘要： A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releasably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion.

摘要翻译： 用于递送闭塞元件的装置包括细长的推动器构件，其具有在远端和近端之间延伸的内腔。 细长释放构件可滑动地设置在细长推动构件的内腔内。 保持构件设置在细长推动器构件的远端上，并且包括具有孔径的手指部分，其尺寸设置成容纳细长释放构件的远端。 提供诸如线圈的闭塞元件，并且包括位于其近端处的固定构件。 固定构件可释放地固定到保持构件的指状部分。 当细长释放构件设置在手指部分的孔中时，固定构件被固定到指状部分，并且当细长释放构件从手指部分的孔向近侧缩回时，固定构件被固定到指状部分。

公开(公告)号：US20080306504A1

公开(公告)日：2008-12-11

申请号：US11942929

申请日：2007-11-20

申请人： Thazin Win ,  Like Que ,  Esther Chang ,  Ann Huang

发明人： Thazin Win ,  Like Que ,  Esther Chang ,  Ann Huang

IPC分类号： A61B17/00

CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B2017/0053 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12095 ,  Y10T29/49826

摘要： A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the locking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member.

摘要翻译： 用于传送闭塞元件的装置包括具有内腔的细长推动器构件。 锁定构件设置在细长推动构件的内腔内。 可移动的细长释放构件设置在细长推动构件的内腔内。 长丝被固定到细长释放构件的远端。 当细丝通过闭塞构件上的固定构件并且被夹紧或楔入锁定构件和细长释放构件之间时，闭塞构件被锁定到细长释放构件。 当细长释放构件相对于细长推动构件向近侧缩回时，闭塞元件处于未锁定状态。 长丝与细长的释放构件一起向近侧缩回，直到细丝与闭塞构件的固定构件分离或脱离。

公开(公告)号：US06723706B2

公开(公告)日：2004-04-20

申请号：US09423198

申请日：2000-02-17

申请人： Eugen Uhlmann ,  Anuschirwan Peyman ,  David William Will ,  Esther Chang ,  Kathleen Pirollo ,  Antonina Rait

发明人： Eugen Uhlmann ,  Anuschirwan Peyman ,  David William Will ,  Esther Chang ,  Kathleen Pirollo ,  Antonina Rait

IPC分类号： A61K4800

CPC分类号： C07H21/02 ,  A61K38/00 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/345 ,  C12N2310/351 ,  C12N2310/3531

摘要： The invention relates to a specific modified oligonucleotide complementary to a section of the human Ha-ras gene and mRNA, and its use to specifically regulate, modulate or inhibit expression of the HA-ras gene, and its use as a pharmaceutical for the treatment of conditions arising from the abnormal expression of the Ha-Ras gene, in particular in combination with chemotherapy and radiotherapy. The modified oligodeoxynucleotide according to the invention has the sequence 5′-TxAxTxTxCxCxGxTxCxAxT-3′-O—PO2—O—R (SEQ ID NO:1), wherein X is an internucleotide linkage of type o or s, with the proviso that x is an s linkage at least 4 times and at most 9 times, and o means a phosphodiester internucleoside linkage, s means a phosphorothioate internucleoside linkage, R means a C8-C21 alkyl group, —(CH2—CH2O)n-(CH2)m—CH3, or —CH2—CH(OH)CH2O—(CH2)q—CH3 wherein n is an integer from 1 to 6, m is an integer from 0 to 20 and q is an integer from 7 to 20 and A is 2′-deoxyadenosine, G is 2′-deoxyguanosine, C is 2′-deoxycytidine and T is thymidine.

摘要翻译： 本发明涉及与人Ha-ras基因和mRNA的部分互补的特异性修饰寡核苷酸及其用于特异性调节，调节或抑制HA-ras基因表达的用途及其作为治疗用途的药物的用途 Ha-Ras基因异常表达引起的病情，特别是与化疗和放疗相结合。 根据本发明的修饰的寡脱氧核苷酸具有序列5'-TxAxTxTxCxCxGxTxCxAxT-3'-O-PO2-OR（SEQ ID NO：1），其中X是o或s型的核苷酸间键，条件是x是 s是至少4次，最多9次，o表示磷酸二酯核苷间键，s表示硫代磷酸酯核苷间键，R表示C8-C21烷基， - （CH2-CH2O）n-（CH2）m-CH3 ，或-CH 2 -CH（OH）CH 2 O-（CH 2）q -CH 3，其中n为1至6的整数，m为0至20的整数，q为7至20的整数，A为2'- 脱氧腺苷，G为2'-脱氧鸟苷，C为2'-脱氧胞苷，T为胸苷。

公开(公告)号：US20050063950A1

公开(公告)日：2005-03-24

申请号：US10820144

申请日：2004-04-08

申请人： Esther Chang ,  Kathleen Pirollo ,  Liang Xu ,  William Alexander

发明人： Esther Chang ,  Kathleen Pirollo ,  Liang Xu ,  William Alexander

IPC分类号： A61K38/17 ,  A61K47/48 ,  A61K48/00 ,  C12N15/86 ,  C12N15/861 ,  C12N15/87 ,  C12P21/04 ,  C12N15/867

CPC分类号： C12N15/86 ,  A61K38/1709 ,  A61K47/6901 ,  A61K48/00 ,  C12N15/87 ,  C12N2710/10343 ,  C12N2710/10345 ,  A61K2300/00

摘要： The present invention relates to gene transfer and gene therapy technology. More specifically, the invention provides compositions and methods for targeted virus delivery. The method utilizes a method of mixing the virus, which may be a recombinant virus which will express a protein of interest or a nucleic acid of interest, with a cell-targeting ligand, e.g., transferrin. The virus and ligand are mixed without crosslinkers or agents which would covalently bond the virus and ligand. This simple mixing causes less inactivation than chemically linking the ligand to the virus and therefore results in a more active therapeutic composition than obtained by methods which utilize crosslinking agents.

摘要翻译： 本发明涉及基因转移和基因治疗技术。 更具体地，本发明提供了靶向病毒递送的组合物和方法。 该方法利用将病毒（其可以表达感兴趣的蛋白质或感兴趣的核酸）的重组病毒与细胞靶向配体例如转铁蛋白混合的方法。 将病毒和配体混合而不会共价结合病毒和配体的交联剂或试剂。 这种简单的混合导致比化学连接配体与病毒更少的失活，因此导致比通过利用交联剂的方法获得的更有效的治疗组合物。