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    Tactile graphic-based interactive overlay assembly and computer system for the visually impaired
    1.
    发明授权
    Tactile graphic-based interactive overlay assembly and computer system for the visually impaired 有权

    公开(公告)号：US07106220B2

    公开(公告)日：2006-09-12

    申请号：US10245815

    申请日：2002-09-17

    申请人： Karen Gourgey ,  Steven Landau

    发明人： Karen Gourgey ,  Steven Landau

    IPC分类号： G09G5/00 ,  G06F3/00 ,  G06F9/00

    CPC分类号： G06F3/04886 ,  G09B21/005

    摘要： A computer-based system permitting a visually impaired user to interact with tactile graphic-based interactive software applications is provided. The system includes a host computer having a data processor and a drive for running the interactive software applications and a pressure sensitive work pad. The work pad has X and Y pressure sensitive members disposed in a grid array for providing unique location output signals corresponding to each different location on the grid array. The work pad is operatively connected to the host computer and an overlay comprising a sheet is placed over an upper surface of the work pad. The overlay having a work space which bears tactile indicia which corresponds to a selected one of the interactive software applications and also includes a tactile graphical user interface (TGUI) formed thereon. The TGUI has a plurality of tactile control members which generate location output signals when pressed. These output signals are communicated to the computer which processes the signals as control signals directing the computer to perform an operation. Methods of calibrating the overlays and identifying the overlays are also provided.

    METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS
    2.
    发明申请
    METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS 审中-公开
    使用具有平滑肌肉调节剂的ALPHA2DELTA亚音频通道调制器治疗下尿路性疾病的方法

    公开(公告)号：US20080085916A1

    公开(公告)日：2008-04-10

    申请号：US11952422

    申请日：2007-12-07

    申请人： Matthew Fraser ,  Karl Thor ,  Edward Burgard ,  Lee Brettman ,  Steven Landau ,  Daniel Ricca

    发明人： Matthew Fraser ,  Karl Thor ,  Edward Burgard ,  Lee Brettman ,  Steven Landau ,  Daniel Ricca

    IPC分类号： A61K31/135 ,  A61K31/195 ,  A61K31/44 ,  A61K31/445 ,  A61P13/00

    CPC分类号： A61K45/06 ,  A61K31/195 ,  A61K31/197 ,  A61K31/216 ,  A61K2300/00

    摘要： A method is provided for using α2δ subunit calcium channel modulators or other compounds that interact with the α2δ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, α2δ subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.

    摘要翻译： 提供了一种使用α2 N 3亚基钙通道调节剂或与α2-δ钙通道亚基相互作用的其它化合物与一种或多种具有平滑肌的化合物组合的方法 治疗和/或减轻与正常和脊髓损伤患者的疼痛和非痛苦的下尿路疾病相关的症状的调节作用。 根据本发明，α2 N亚基钙通道调节剂包括GABA类似物（例如加巴喷丁和普瑞巴林），加巴喷丁的稠合双环或三环氨基酸类似物和氨基酸化合物。 具有平滑肌调节作用的化合物包括抗毒蕈碱，β3肾上腺素能激动剂，解痉药，神经激肽受体拮抗剂，缓激肽受体拮抗剂和一氧化氮供体。

    Method of treating lower urinary tract disorders
    3.
    发明申请
    Method of treating lower urinary tract disorders 失效

    公开(公告)号：US20050026909A1

    公开(公告)日：2005-02-03

    申请号：US10863770

    申请日：2004-06-07

    申请人： Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    发明人： Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    IPC分类号： A01N43/54 ,  A61K31/00 ,  A61K31/135 ,  A61K31/519 ,  A61K31/535 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06

    CPC分类号： A61K31/519 ,  A61K31/00 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

    Card configured to receive separate battery
    4.
    发明授权
    Card configured to receive separate battery 有权
    卡配置为接收单独的电池

    公开(公告)号：US07967214B2

    公开(公告)日：2011-06-28

    申请号：US11966018

    申请日：2007-12-28

    申请人： Steven Landau ,  David Corey

    发明人： Steven Landau ,  David Corey

    IPC分类号： G06K19/06

    CPC分类号： G06K19/077 ,  G06K19/0702

    摘要： An electronic card comprises a thin, flexible substrate having electrical circuitry embedded therein. An activation device is disposed in the substrate and is configured to complete a circuit in response to a stimulus, such as light or sound. An output device is disposed in the substrate and is configured to produce an output, such as music or vibration, wherein the output device is activated upon the completion of the circuit by the activation device. A cavity is formed in an outer surface of the substrate and has electrical contacts at an inner portion thereof in electrical communication with the electrical circuitry. The cavity further comprises retaining means for replaceably retaining a battery in the cavity to enable the battery to provide power to the electrical circuitry, the activation device, and the output device. The retaining means allows a battery to be removed from the cavity and replaced with another battery.

    摘要翻译： 电子卡包括一个薄而柔性的基片，其中嵌有电路。 激活装置设置在基板中并且被配置为响应于诸如光或声的刺激来完成电路。 输出装置设置在基板中并且被配置为产生诸如音乐或振动的输出，其中输出装置在激活装置完成电路时被激活。 空腔形成在基板的外表面中，并且在其内部具有与电路电连通的电触点。 空腔还包括用于可替换地将电池保持在空腔中的保持装置，以使电池能够向电路，激活装置和输出装置提供电力。 保持装置允许将电池从腔中移除并用另一个电池替代。

    Mailing Apparatus For Powered Cards
    5.
    发明申请
    Mailing Apparatus For Powered Cards 有权
    电子卡邮寄设备

    公开(公告)号：US20080156690A1

    公开(公告)日：2008-07-03

    申请号：US11966026

    申请日：2007-12-28

    申请人： Steven Landau ,  Teresa Taylor

    发明人： Steven Landau ,  Teresa Taylor

    IPC分类号： B65D85/00

    CPC分类号： B65D81/05 ,  A45C11/182 ,  A45C2011/186

    摘要： Apparatuses and methods for packaging electronically powered cards are provided for maintaining electronically powered cards in a deactivated state. In an embodiment, a housing having a face panel and two side panels attached to the face panel at opposite sides is configured to provide an offset distance between an activation device on the card and the housing so that the activation device is prevented from being activated by a force exerted on the housing. Annular or circular devices can also be provided for establishing an offset distance between activation devices on the card and planar substrates.

    摘要翻译： 提供用于包装电动卡片的装置和方法，用于将电动卡片保持在停用状态。 在一个实施例中，具有面板和在相对侧附接到面板的两个侧面板的壳体被配置为提供卡上的启动装置与壳体之间的偏移距离，使得激活装置被防止被 施加在壳体上的力。 还可以提供环形或圆形装置，用于在卡和平面基板上的激活装置之间建立偏移距离。

    Method of treating lower urinary tract disorders
    9.
    发明申请
    Method of treating lower urinary tract disorders 审中-公开
    治疗下尿路疾病的方法

    公开(公告)号：US20050020577A1

    公开(公告)日：2005-01-27

    申请号：US10863771

    申请日：2004-06-07

    申请人： Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    发明人： Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    IPC分类号： A01N43/54 ,  A61K31/00 ,  A61K31/135 ,  A61K31/519 ,  A61K31/535 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06

    CPC分类号： A61K31/519 ,  A61K31/00 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

    摘要翻译： 本发明涉及一种治疗需要治疗的受试者的下尿路疾病的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿。 该方法包括向需要治疗的受试者施用治疗有效量的具有5-HT 3受体拮抗剂活性的化合物和NorAdrenaline再摄取抑制剂（NARI）活性。 本发明还涉及在需要治疗的受试者中治疗下尿路障碍的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿， 包括向所述受试者共同施用第一量的5-HT 3拮抗剂和第二量的NARI，其中第一和第二量一起包含治疗有效量或者以治疗有效量存在。