公开(公告)号：US07880154B2

公开(公告)日：2011-02-01

申请号：US12132597

申请日：2008-06-03

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10 ,  A61N5/00 ,  G21K1/02

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

公开(公告)号：US08696538B2

公开(公告)日：2014-04-15

申请号：US12986420

申请日：2011-01-07

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Abstract translation: 提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。 在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。 一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。 对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

公开(公告)号：US08658992B2

公开(公告)日：2014-02-25

申请号：US13043892

申请日：2011-03-09

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/00

CPC classification number: A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

公开(公告)号：US20130102830A1

公开(公告)日：2013-04-25

申请号：US13806677

申请日：2011-06-22

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/00 ,  A61N5/10 ,  G01T1/29 ,  H05K999/00

Abstract: Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.

Abstract translation: 提供了用于允许操纵由辐射递送装置输送的用于建议的受试者治疗的可实现的剂量分布估计的方法。 一种这样的方法包括：确定期望修饰剂量值的剂量修饰体素和所需剂量修饰的相应量级; 对于多个波束中的每一个：（i）将波束表征为子波束的二维阵列，其中每个子波束与对应的强度值相关联，并且射线代表子束进入空间的投影; 和（ii）识别具有与剂量修改体素相交的相关联的射线的一个或多个剂量变化子束; 修改至少一个剂量变化子束的强度值; 以及更新所述可实现的剂量分布估计以考虑所述剂量变化子束中的至少一个的修改的强度值。

公开(公告)号：US07906770B2

公开(公告)日：2011-03-15

申请号：US11996932

申请日：2006-07-25

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10 ,  A61N5/00

CPC classification number: A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Abstract translation: 提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。 在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。 一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。 对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

公开(公告)号：US20080226030A1

公开(公告)日：2008-09-18

申请号：US11996932

申请日：2006-07-25

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/00

CPC classification number: A61N5/1031 ,  A61B6/032 ,  A61B6/4085 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Abstract translation: 提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。 在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。 一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。 对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

公开(公告)号：US20060256915A1

公开(公告)日：2006-11-16

申请号：US11383188

申请日：2006-05-12

Applicant: Karl Otto ,  Marie-Pierre Milette

Inventor： Karl Otto ,  Marie-Pierre Milette

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1042 ,  A61N2005/1032 ,  A61N2005/1035

Abstract: Radiation may be delivered in a number of segments shaped by a multi-leaf collimator. The collimator may be at different angles of rotation for the different segments. A method for planning radiation treatment involves obtaining an optimized set of collimator configurations by a direct aperture optimization method that takes into account collimator rotation. In some embodiments, area constraints are applied to the optimization. Methods according to embodiments of the invention can generate efficient treatment plans.

Abstract translation: 辐射可以在由多叶准直器成形的多个片段中传送。 对于不同的段，准直器可以处于不同的旋转角度。 一种用于规划辐射治疗的方法包括通过考虑到准直器​​旋转的直接孔径优化方法来获得优化的准直器配置集合。 在一些实施例中，面积约束被应用于优化。 根据本发明的实施例的方法可以产生有效的治疗计划。

公开(公告)号：US09289627B2

公开(公告)日：2016-03-22

申请号：US13806677

申请日：2011-06-22

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10 ,  A61N5/00 ,  G01T1/29

CPC classification number: A61N5/1031 ,  A61N5/00 ,  A61N5/10 ,  G01T1/29 ,  H05K999/00

Abstract: Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.

Abstract translation: 提供了用于允许操纵由辐射递送装置输送的用于建议的受试者治疗的可实现的剂量分布估计的方法。 一种这样的方法包括：确定期望修饰剂量值的剂量修饰体素和所需剂量修饰的相应量级; 对于多个波束中的每一个：（i）将波束表征为子波束的二维阵列，其中每个子波束与对应的强度值相关联，并且射线代表将子束投影到空间中; 和（ii）识别具有与剂量修改体素相交的相关联的射线的一个或多个剂量变化子束; 修改至少一个剂量变化子束的强度值; 以及更新所述可实现的剂量分布估计以考虑所述剂量变化子束中的至少一个的修改的强度值。

公开(公告)号：US08699664B2

公开(公告)日：2014-04-15

申请号：US13298195

申请日：2011-11-16

Applicant: Karl Otto ,  Ante Mestrovic

Inventor： Karl Otto ,  Ante Mestrovic

IPC: A61N5/00

CPC classification number: A61N5/1067 ,  A61N5/1031 ,  A61N5/1038 ,  A61N5/1045 ,  A61N2005/1061

Abstract: Radiation treatment methods comprise: obtaining initial image data of a region of interest; initially optimizing one or more radiation delivery variables of a radiation treatment plan based on the initial image data; and dividing the plan into one or more fractional treatments. Each fractional treatment comprises: delivering an initial portion of a fraction based on the one or more initially optimized radiation delivery variables; obtaining fractional image data pertaining to the region of interest; fractionally optimizing the one or more radiation delivery variables based at least in part on the fractional image data; and delivering a subsequent portion of the fraction based on the one or more fractionally optimized radiation delivery variables. At least part of delivering the initial portion of the fraction overlaps temporally with at least one of: obtaining the fractional image data and fractionally optimizing the one or more radiation delivery variables.

Abstract translation: 辐射处理方法包括：获得感兴趣区域的初始图像数据; 基于初始图像数据最初优化辐射治疗计划的一个或多个辐射递送变量; 并将计划划分为一个或多个分数处理。 每个分级处理包括：基于一个或多个初始优化的辐射递送变量递送部分的初始部分; 获得与感兴趣区域有关的分数图像数据; 至少部分地基于分数图像数据对所述一个或多个辐射递送变量进行分数优化; 以及基于所述一个或多个分数优化的辐射传递变量递送所述分数的后续部分。 递送分数的初始部分的至少一部分与时间上重叠以下中的至少一个：获得分数图像数据并分数优化一个或多个辐射递送变量。

公开(公告)号：US20120123184A1

公开(公告)日：2012-05-17

申请号：US13298195

申请日：2011-11-16

Applicant: Karl Otto ,  Ante Mestrovic

Inventor： Karl Otto ,  Ante Mestrovic

IPC: A61N5/00

CPC classification number: A61N5/1067 ,  A61N5/1031 ,  A61N5/1038 ,  A61N5/1045 ,  A61N2005/1061

Abstract: Radiation treatment methods comprise: obtaining initial image data of a region of interest; initially optimizing one or more radiation delivery variables of a radiation treatment plan based on the initial image data; and dividing the plan into one or more fractional treatments. Each fractional treatment comprises: delivering an initial portion of a fraction based on the one or more initially optimized radiation delivery variables; obtaining fractional image data pertaining to the region of interest; fractionally optimizing the one or more radiation delivery variables based at least in part on the fractional image data; and delivering a subsequent portion of the fraction based on the one or more fractionally optimized radiation delivery variables. At least part of delivering the initial portion of the fraction overlaps temporally with at least one of: obtaining the fractional image data and fractionally optimizing the one or more radiation delivery variables.

Abstract translation: 辐射处理方法包括：获得感兴趣区域的初始图像数据; 基于初始图像数据最初优化辐射治疗计划的一个或多个辐射递送变量; 并将计划划分为一个或多个分数处理。 每个分级处理包括：基于一个或多个初始优化的辐射递送变量递送部分的初始部分; 获得与感兴趣区域有关的分数图像数据; 至少部分地基于分数图像数据对所述一个或多个辐射递送变量进行分数优化; 以及基于所述一个或多个分数优化的辐射传递变量递送所述分数的后续部分。 递送分数的初始部分的至少一部分与时间上重叠以下中的至少一个：获得分数图像数据并分数优化一个或多个辐射递送变量。