公开(公告)号：US12076584B2

公开(公告)日：2024-09-03

申请号：US17364663

申请日：2021-06-30

Applicant: Varian Medical Systems Particle Therapy GmbH & Co, KG ,  Varian Medical Systems International AG

Inventor： Tina Pfeiler ,  Reynald Vanderstraeten ,  Michiko Rossi ,  Isabel Huth ,  Viljo Petaja

IPC: A61N5/10 ,  G21K5/04

CPC classification number: A61N5/1031 ,  A61N5/1071 ,  G21K5/04 ,  A61N2005/1034 ,  A61N2005/1087 ,  A61N2005/1089

Abstract: Presented systems and methods enable efficient and effective robust radiation treatment planning and treatment, including analysis of dose rate robustness. In one embodiment, a method comprising accessing treatment plan information, accessing information corresponding to an uncertainty associated with implementation of the radiation treatment plan, and generating a histogram, wherein the histogram conveys a characteristic of the treatment plan including an impact of the uncertainty on the characteristic. The histogram can be a dose rate volume histogram and can be utilized to test a degree of robustness of a treatment plan (e.g., including allowance for uncertainty scenarios, etc.). The uncertainty can be associated with potential variation associated with tolerances (e.g., radiation system/machine performance tolerance, patient characteristic tolerances, etc.) and set up issues (e.g., variation in initial system/machine set up, variation patient setup/position, etc.).

公开(公告)号：US20240115881A1

公开(公告)日：2024-04-11

申请号：US18476134

申请日：2023-09-27

Applicant: Rutgers, The State University of New Jersey

Inventor： Roger W. Howell ,  Sumudu Katugampola ,  Jianchao Wang

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N2005/1034

Abstract: A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs.

公开(公告)号：US11938341B2

公开(公告)日：2024-03-26

申请号：US17555756

申请日：2021-12-20

Applicant: Siemens Healthineers International AG

Inventor： Petri Hirvonen ,  Matti Ropo ,  Douglas Barnett ,  Timo Koponen

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1028 ,  A61N2005/1034 ,  A61N2005/1087

Abstract: These teachings provide for quickly yet accurately forming an influence matrix by generating the influence matrix via integration with a Monte Carlo particle transport simulation. The resultant influence matrix can then be utilized in an ordinary manner when optimizing a radiation treatment plan. By one approach, the foregoing comprises generating the influence matrix via integration with a Monte Carlo particle transport simulation on a particle-by-particle basis. For example, for each particle, these teachings can provide for identifying a spot to which the particle belongs and then adding a dose deposited by the particle during transport to an influence matrix element that corresponds to a spot to which the particle belongs and a voxel to where the dose was deposited.

公开(公告)号：US11883686B2

公开(公告)日：2024-01-30

申请号：US17635411

申请日：2019-09-04

Applicant: IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

Inventor： Yong Kyun Kim ,  Hyun Tai Chung ,  Jun Sik Park ,  Jae Bum Son ,  Sang Min Lee ,  Dong Geon Kim ,  Tae Hoon Kim ,  Jae Young Jeong

IPC: A61N5/10 ,  G01T1/161

CPC classification number: A61N5/1071 ,  A61N5/1031 ,  G01T1/161 ,  A61N2005/1034

Abstract: Proposed is an apparatus for verifying a radiation dose using a patient-specific tumor-shaped scintillator including a probe adapter to which a 3D tumor-shaped scintillator having a guide is attached; a receiving portion to which the probe adapter is detachably coupled; a light guide which extends from the receiving portion and includes optical fiber transmitting visible light generated by irradiating radiation in the 3D tumor-shaped scintillator; a photomultiplier tube converting the visible light transmitted from the light guide into an electric signal and amplifying the converted electric signal; and a current electrometer measuring an output current by inputting the electric signal of the photomultiplier tube.

公开(公告)号：US20240001146A1

公开(公告)日：2024-01-04

申请号：US18243703

申请日：2023-09-08

Applicant: Siemens Healthineers International AG

Inventor： Santtu Ollila

IPC: A61N5/10 ,  G06T7/00

CPC classification number: A61N5/1031 ,  A61N5/1037 ,  A61N5/1045 ,  A61N5/1081 ,  A61N5/103 ,  A61N5/1039 ,  G06T7/0012 ,  A61N2005/1034 ,  G06T2207/20072 ,  G06T2207/30004 ,  G06T2207/30241

Abstract: A method of determining treatment geometries for a radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs); defining a delivery coordinate space (DCS); for each beam's eye view (BEV) plane of each vertex in the DCS, and for each ROI, evaluating a dose of the ROI using transport solutions; evaluating a BEV scores of each pixel of the BEV plane using the doses of the one or more ROIs; determining one or more BEV regions in the BEV plane based on the BEV scores; determining a BEV region connectivity manifold based on the BEV regions; determining a set of treatment trajectories based on the BEV region connectivity manifold; and determining one or more IMRT fields. Each treatment trajectory defines a path through a set of vertices in the DCS. Each IMRT field defines a direction of incidence corresponding to a vertex in the DCS.

公开(公告)号：US11826560B2

公开(公告)日：2023-11-28

申请号：US17999708

申请日：2021-05-19

Applicant: RaySearch Laboratories AB

Inventor： Tianfang Zhang

IPC: A61N5/10 ,  G16H20/40

CPC classification number: A61N5/1039 ,  A61N5/1031 ,  A61N5/1038 ,  G16H20/40 ,  A61N2005/1034

Abstract: A computer-implemented method for generating a radiation therapy treatment plan for a volume of a patient, the method comprising: receiving an image of the volume; receiving at least one dose-distribution-derived function configured to provide a value as an output based on, as input, at least part of a dose distribution defined relative to the image; receiving a first probability distribution and at least a second, different, probability distribution, the first and at least second probability distributions; defining a multi-criteria optimization problem comprising at least a first objective function based on the at least one dose-distribution-derived function, the first probability distribution and a loss function; and a second objective function based on the at least one dose-distribution-derived function, the second probability distribution and the loss function; and performing a multi-criteria optimization process based on the at least two objective functions to generate at least two output treatment plans.

公开(公告)号：US20230302296A1

公开(公告)日：2023-09-28

申请号：US18317910

申请日：2023-05-15

Applicant: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.

Inventor： Gui LI ,  Yin TANG ,  Shaoqiang YE ,  Juan LIU

IPC: A61N5/10 ,  G16H50/50 ,  G16H20/40

CPC classification number: A61N5/1031 ,  G16H50/50 ,  G16H20/40 ,  A61N5/1042 ,  A61N2005/1034

Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.

公开(公告)号：US20230285773A1

公开(公告)日：2023-09-14

申请号：US17692082

申请日：2022-03-10

Applicant: VARIAN MEDICAL SYSTEMS, INC.

Inventor： Alexander Maslowski ,  Douglas Allen Barnett ,  Todd Wareing

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N2005/1034 ,  A61N2005/1087 ,  A61N2005/1089

Abstract: Embodiments described herein provide for coupling Monte Carlo source modeling with deterministic dose calculations. An internal volumetric first scatter distributed source of a patient is determined using Monte Carlo simulations and ingested into one or more dosing algorithms. The dosing algorithms use the source model to determine a dose deposition.

公开(公告)号：US11717701B2

公开(公告)日：2023-08-08

申请号：US16586661

申请日：2019-09-27

Applicant: Siemens Healthineers International AG ,  Varian Medical Systems, Inc.

Inventor： Santtu Ollila ,  Todd Arlin Wareing ,  John Morton McGhee ,  Douglas Allen Barnett, Jr. ,  Alexander Enrique Maslowski

IPC: A61N5/10 ,  G06T7/00

CPC classification number: A61N5/1031 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1045 ,  A61N5/1081 ,  G06T7/0012 ,  A61N2005/1034 ,  G06T2207/20072 ,  G06T2207/30004 ,  G06T2207/30241

Abstract: A method of beam angle optimization for an IMRT radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining a set of IMRT fields based on the BEV region connectivity manifold.

公开(公告)号：US09901751B1

公开(公告)日：2018-02-27

申请号：US15250012

申请日：2016-08-29

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond P. Boisseau ,  John S. Gordon ,  Andrew Dart ,  Julia C. Nett

IPC: A61N5/10 ,  H05K5/02 ,  H05K5/00 ,  H05K5/04 ,  H05K9/00 ,  H01J37/24

CPC classification number: A61N5/1075 ,  A61N5/1048 ,  A61N2005/1034 ,  A61N2005/1087 ,  H01J37/243 ,  H05K5/0026 ,  H05K5/0247 ,  H05K5/04 ,  H05K9/0049

Abstract: A multi-layer charged particle beam characterization system is disclosed, and method for using the same. A typical embodiment includes a plurality of two-sided metal plates, arranged as a stack, each metal plate having an electrical contact tab extending from at least one common edge of the metal plate, and a plurality of insulator films disposed between adjacent metal plates, each insulator film sized to match its corresponding metal plate. The tabs are coupled to a printed circuit board and connected to an external electrical connector to register a number of metal plates and insulator layers through which a charged particle beam has penetrated.