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1.发明授权
公开(公告)号：US5679260A
公开(公告)日：1997-10-21
申请号：US533742
申请日：1995-09-26
IPC分类号： A61M1/36 , A61K31/715 , A61K35/14 , A61M1/34 , B01J20/26 , B01J41/04 , C07K14/52 , C07K14/525 , C07K1/14 , C07K1/30 , C07K1/34
CPC分类号： B01J41/04 , A61M1/3472 , A61M1/3482 , A61M1/3486 , C07K14/525 , Y10T436/25375 , Y10T436/255
摘要： Disclosed is a process to remove tumour necrosis factor .alpha. (TNF.alpha.) or/and bacterial lipopolysaccharides (LPS) from an aqueous liquid, in particular blood, blood plasma or serum, in an extracorporeal perfusion system after removing corpuscular blood components if necessary, wherein (a) the pH value of the body fluid is adjusted to pH
摘要翻译： 公开了一种在需要时除去血球成分之后，从体外灌注系统中从水性液体，特别是血液，血浆或血清中除去肿瘤坏死因子α（TNFα）或/和细菌脂多糖（LPS）的方法，其中 （a）将体液的pH值调节至pH <6，（b）加入聚阴离子形式的沉淀试剂，（c）通过过滤或离心除去沉淀物质，（d） 所得液体通过阴离子交换器。
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2.发明授权
公开(公告)号：US5679775A
公开(公告)日：1997-10-21
申请号：US634919
申请日：1996-04-19
IPC分类号： A61K35/14 , A61K35/16 , A61M1/36 , B01D15/04 , B01J20/26 , B01J20/28 , C07K14/525 , C07K3/12 , A61M1/34 , C07K3/20 , C07K13/00
CPC分类号： A61M1/3679 , A61K35/14 , A61K35/16 , C07K14/525
摘要： In order to remove tumor necrosis factor .alpha. (TNF.alpha.) or/and bacterial lipopolysaccharides (LPS, endotoxin) extracorporeally from whole blood or/and blood plasma in an extracorporeal perfusion system, the blood or plasma is passed over a cation exchanger and an anion exchanger material. A device according to the invention for the extracorporeal treatment of patient's blood or plasma therefore contains a cation exchanger material and an anion exchanger material wherein these materials are contained in at least one compartment of an extracorporeal perfusion system.
摘要翻译： 为了在体外灌注系统中从全血或/和血浆中体外除去肿瘤坏死因子α（TNFα）或/和细菌脂多糖（LPS，内毒素），血液或血浆通过阳离子交换剂和阴离子 交换器材料。 因此，根据本发明的用于患者血液或血浆的体外治疗的装置包含阳离子交换剂材料和阴离子交换材料，其中这些材料包含在体外灌注系统的至少一个隔间中。
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公开(公告)号：US07553482B2
公开(公告)日：2009-06-30
申请号：US10480476
申请日：2002-06-12
IPC分类号： A61K31/70 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/722 , A61K33/26 , A61P19/00 , A61P19/08 , A61P9/00 , A61P9/10
CPC分类号： A61K33/26 , Y10S514/824 , Y10S514/866
摘要： The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.
摘要翻译： 本发明涉及使用多金属氧化物氢氧化物改性的吸附材料，用于影响钙水平，特别是用于治疗和/或预防动脉粥样硬化血管疾病和/或骨代谢紊乱。
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4.发明授权
公开(公告)号：US5795786A
公开(公告)日：1998-08-18
申请号：US692642
申请日：1996-08-06
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2800/044 , Y10T436/104165 , Y10T436/107497 , Y10T436/25125
摘要： A process and a reagent for the specific and direct determination of the LDL-fraction in the presence of other serum lipoproteins by adding a polymeric LDL-aggregating agent, followed by direct turbidimetric measurement of the LDL aggregate. Preferred are polymers which have a comb or brush type structure with the side groups having acid character, such as branched alkane sulfonic acids.
摘要翻译： 通过加入聚合物低密度脂蛋白聚集剂，然后直接测量LDL聚集体，在其它血清脂蛋白存在下特异性和直接测定LDL-级分的方法和试剂。 优选的是具有具有酸性特征的侧基的梳子或刷子结构的聚合物，例如支链烷烃磺酸。
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5.发明申请Device for removing bacterial lipopolysaccharides and/or lipoteichoic acids from protein-containing fluids and its use for the treatment of sepsis 有权用于从含蛋白质的流体中除去细菌脂多糖和/或脂磷壁酸的装置及其用于治疗败血症的装置公开(公告)号：US20050009001A1
公开(公告)日：2005-01-13
申请号：US10860786
申请日：2004-06-03
IPC分类号： A61M1/36 , B01D61/00 , B01D67/00 , B01D69/08 , B01D71/56 , B01D71/82 , A01N1/02 , A61M31/00 , C02F1/44
CPC分类号： B01D61/00 , A61M1/3679 , A61M2202/203 , B01D67/0093 , B01D69/08 , B01D71/56 , B01D71/82 , B01D2323/38 , A61M2202/0057
摘要： A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.
摘要翻译： 用于在体外灌注系统中从血液或血浆中除去细菌脂多糖和脂磷壁酸的装置在可并入灌注系统的壳体中含有适于选择性除去细菌脂多糖和脂磷壁酸的中空纤维材料， 所述装置被布置成使得通过所述壳体的第一开口进入的血液或等离子体在通过所述壳体的第二开口之前必须通过所述中空纤维材料，并被引导到所述灌注回路的其余部分。
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6.发明授权Process for the selective elimination of inorganic phosphate from liquids by means of adsorbent materials modified with polynuclear metal oxyhydroxiders and production of the adsorbent materials 失效通过用多金属羟基氧化物改性的吸附材料和液体吸收材料的生产来选择性地从液体中去除无机磷酸盐的方法
公开(公告)号：US5846426A
公开(公告)日：1998-12-08
申请号：US720925
申请日：1996-10-07
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/02 , B01J20/10 , B01J20/22 , B01J20/32 , B01D15/08 , C08B37/00
CPC分类号： B01D15/00 , A61M1/3679 , B01J20/223 , B01J20/286 , B01J20/3078 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3265 , A61M1/34 , B01J2220/54 , B01J2220/58
摘要： The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
摘要翻译： 本发明涉及用多核金属羟基氧化物改性的吸附材料用于从液体中选择性地除去无机磷酸盐的用途，特别是从含有蛋白质如全血，血浆，肠液的液体以及透析液 以及用于生产用于选择性除去无机磷酸酯的口服应用药物的方法，其中根据本发明使用的吸附剂材料本身或压制成粉末形式的涂层具有耐受 胃酸或分配到耐酸胶囊中。 为了选择性地消除体外灌注系统中的无机磷酸盐，诸如全血或血浆的体液通过一种吸附材料。
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7.发明授权Process for the selective elimination of inorganic phosphate from liquids by means of absorbent materials modified with polynuclear metal oxyhydroxides 有权通过用多核金属羟基氧化物改性的吸收材料从液体中选择性地除去无机磷酸盐的方法
公开(公告)号：US6103126A
公开(公告)日：2000-08-15
申请号：US145129
申请日：1998-09-01
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/02 , B01J20/10 , B01J20/22 , B01J20/32 , A61K33/06 , A61K33/26 , C08B37/02
CPC分类号： B01D15/00 , A61M1/3679 , B01J20/223 , B01J20/286 , B01J20/3078 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3265 , A61M1/34 , B01J2220/54 , B01J2220/58
摘要： The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
摘要翻译： 本发明涉及用多核金属羟基氧化物改性的吸附材料用于从液体中选择性地除去无机磷酸盐的用途，特别是从含有蛋白质如全血，血浆，肠液的液体以及透析液 以及用于生产用于选择性除去无机磷酸酯的口服应用药物的方法，其中根据本发明使用的吸附剂材料本身或压制成粉末形式的涂层具有耐受 胃酸或分配到耐酸胶囊中。 为了选择性地消除体外灌注系统中的无机磷酸盐，诸如全血或血浆的体液通过一种吸附材料。
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8.发明授权Process for the selective elimination of inorganic phosphate from liquids by means of adsorbent materials modified with polynuclear metal oxyhydroxides 失效通过用多金属羟基氧化物改性的吸附剂材料从液体中选择性地除去无机磷酸盐的方法
公开(公告)号：US5514281A
公开(公告)日：1996-05-07
申请号：US417844
申请日：1995-04-06
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/02 , B01J20/10 , B01J20/22 , B01J20/32 , B01D15/08 , B01J20/06
CPC分类号： B01D15/00 , A61M1/3679 , B01J20/223 , B01J20/286 , B01J20/3078 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3265 , A61M1/34 , B01J2220/54 , B01J2220/58
摘要： The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.
摘要翻译： 本发明涉及用多核金属羟基氧化物改性的吸附材料用于从液体中选择性地除去无机磷酸盐的用途，特别是从含有蛋白质如体液，血浆，肠内液体以及透析液 以及用于生产用于选择性除去无机磷酸酯的口服应用药物的方法，其中根据本发明使用的吸附剂材料本身或压制成粉末形式的涂层具有耐受 胃酸或分配到耐酸胶囊中。 为了选择性地消除体外灌注系统中的无机磷酸盐，诸如全血或血浆的体液通过一种吸附材料。
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9.发明授权Device for removing bacterial lipopolysaccharides and/or lipoteichoic acids from protein-containing fluids and its use for the treatment of sepsis 有权用于从含蛋白质的流体中除去细菌脂多糖和/或脂磷壁酸的装置及其用于治疗败血症的装置公开(公告)号：US07608189B2
公开(公告)日：2009-10-27
申请号：US10860786
申请日：2004-06-03
CPC分类号： B01D61/00 , A61M1/3679 , A61M2202/203 , B01D67/0093 , B01D69/08 , B01D71/56 , B01D71/82 , B01D2323/38 , A61M2202/0057
摘要： A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.
摘要翻译： 用于在体外灌注系统中从血液或血浆中除去细菌脂多糖和脂磷壁酸的装置在可并入灌注系统的壳体中含有适于选择性除去细菌脂多糖和脂磷壁酸的中空纤维材料， 所述装置被布置成使得通过所述壳体的第一开口进入的血液或等离子体在通过所述壳体的第二开口之前必须通过所述中空纤维材料，并被引导到所述灌注回路的其余部分。
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公开(公告)号：US20090123566A1
公开(公告)日：2009-05-14
申请号：US12351882
申请日：2009-01-12
CPC分类号： A61K33/26 , Y10S514/824 , Y10S514/866
摘要： The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.
摘要翻译： 本发明涉及使用多金属氧化物氢氧化物改性的吸附材料，用于影响钙水平，特别是用于治疗和/或预防动脉粥样硬化血管疾病和/或骨代谢紊乱。
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