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公开(公告)号：US06482223B1
公开(公告)日：2002-11-19
申请号：US09585488
申请日：2000-06-01
IPC分类号： A61B1704
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00637 , A61B2017/0065
摘要： Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anti-coagulating agents and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. The present invention provides improved methods of creating hemostasis or control of bleeding at the site of wounds, particularly wounds created in arteries during procedures employing percutaneous access. The invention preferably includes the steps of acquiring an aliquot of a patient's blood, i.e., autologous blood, removing a negatively charged anti-coagulating agent, preferably heparin, from the blood, and preferably initiating the blood's natural clotting cascades and transporting the thus treated blood to the site of the wound where the clotting cascade will be completed producing a clot at the wound site that will create a condition of hemostasis. The invention further provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
摘要翻译： 提供了伤口闭合方法和装置，其通过在基本封闭的无菌容器内激活身体外部的血液流体的凝血级联来利用血液流体，然后将血液流体引入伤口部位以完成凝血。 还公开了提供抑制抗凝血剂和减缓纤维蛋白凝块降解的方法和装置。 还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。 本发明提供改善创伤止血或控制出血的方法，特别是在采用经皮通路的手术过程中在动脉中产生的伤口。 本发明优选包括以下步骤：从血液中获取患者血液等分试样，即自体血液，从血液中除去带负电荷的抗凝血剂，优选肝素，并且优选引发血液的天然凝血级联并输送如此处理的血液 到伤口的位置，凝血级联将完成，在伤口部位产生凝块，形成止血状态。 本发明进一步提供了一种凝血级联引发装置，其包括基本封闭的无菌容纳室，其中可以接收和保留自体或来自供体来源的血液的等分试样。 在优选的实施方案中，无菌容纳室还包括肝素结合剂，其将结合肝素并将其从血液中除去。 在另外的实施方案中，容纳室还将包括促凝剂，其中当血液流体被接受到无菌容纳室中时可以开始凝血级联。
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2.发明授权Clotting cascade initiating apparatus and methods of use and methods of closing wounds 失效凝血级联引发装置和使用方法以及关闭伤口的方法公开(公告)号：US08343084B2
公开(公告)日：2013-01-01
申请号：US12915822
申请日：2010-10-29
CPC分类号： A61B17/00491 , A61B17/0057 , Y10T428/2996 , Y10T428/31928
摘要： A wound closure apparatus and associated methods are provided which utilize blood fluid by activating the clotting cascade of blood fluid within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
摘要翻译： 提供了一种伤口闭合装置和相关方法，其通过在基本上封闭的无菌容器内激活血液流体的凝血级联来利用血液流体，然后将血液流体引入伤口部位以完成凝血。 还公开了一种用于提供抑制抗凝血剂和减缓纤维蛋白凝块降解的方法的装置。 套件也被披露。 本发明提供了一种凝血级联引发装置，其包括基本封闭的无菌容纳室，其中可以接收和保留自体或来自供体来源的血液的等分试样。 在优选的实施方案中，无菌容纳室还包括肝素结合剂，其将结合肝素并将其从血液中除去。 在另外的实施方案中，容纳室还将包括促凝剂，其中当血液流体被接受到无菌容纳室中时可以开始凝血级联。
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3.发明申请公开(公告)号：US20110046574A1
公开(公告)日：2011-02-24
申请号：US12915822
申请日：2010-10-29
CPC分类号： A61B17/00491 , A61B17/0057 , Y10T428/2996 , Y10T428/31928
摘要： A wound closure apparatus is provided which utilizes blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. The invention provides a clotting cascade initiation apparatus including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources, can be received and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
摘要翻译： 提供一种创伤闭合装置，其利用血液流体，通过在基本上封闭的无菌容器内激活身体外部的血液流体的凝血级联，然后将血液流体引入伤口部位以完成凝血。 还公开了一种用于提供抑制抗凝血剂和减缓纤维蛋白凝块降解的方法的装置。 还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。 本发明提供了一种凝血级联引发装置，其包括基本封闭的无菌容纳室，其中可以接收和保留自体或来自供体来源的血液的等分试样。 在优选的实施方案中，无菌容纳室还包括肝素结合剂，其将结合肝素并将其从血液中除去。 在另外的实施方案中，容纳室还将包括促凝剂，其中当血液流体被接受到无菌容纳室中时可以开始凝血级联。
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公开(公告)号：US6159232A
公开(公告)日：2000-12-12
申请号：US212080
申请日：1998-12-15
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00641 , A61B2017/0065
摘要： Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
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公开(公告)号：US5079729A
公开(公告)日：1992-01-07
申请号：US228548
申请日：1988-08-04
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
IPC分类号： G01B11/26
CPC分类号： G01B11/26
摘要： An apparatus for measuring the alignment of two or more adjacent lugs while the lugs are in motion is provided. The alignment measuring apparatus includes a first scanner for detecting the leading edge of a first lug and a second scanner for detecting the leading edge of a second lug positioned adjacent the first. Timing means are provided for measuring the time differential between detection of the first and second lugs and computation means are provided for determining whether adjacent lugs are within alignment tolerances based in part upon the differential time measurement. Alternatively, differential distance measuring means are provided to directly measure the misalignment between the lugs.
摘要翻译： 提供了一种用于在凸起运动时测量两个或更多个相邻凸耳的对准的装置。 对准测量装置包括用于检测第一凸耳的前缘的第一扫描器和用于检测与第一凸耳相邻定位的第二凸耳的前缘的第二扫描器。 提供了用于测量第一和第二凸耳的检测之间的时间差的计时装置和计算装置，用于基于差分时间测量部分地确定相邻凸耳是否在对准公差内。 或者，提供差分距离测量装置以直接测量凸耳之间的不对准。
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6.发明授权Clotting cascade initiating apparatus and methods of use and methods of closing wounds 有权凝血级联引发装置和使用方法以及关闭伤口的方法公开(公告)号：US08652168B2
公开(公告)日：2014-02-18
申请号：US11337278
申请日：2006-01-23
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
CPC分类号： A61L24/0005 , A61B17/00491 , A61B17/0057 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065 , A61M25/0662 , A61M2025/0681
摘要： Wound closure methods and apparata are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparata for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
摘要翻译： 提供伤口闭合方法和装置，其通过在基本上封闭的无菌容器内激活身体外部的血液流体的凝血级联来利用血液，然后将血液流体引入伤口部位以完成凝血。 还公开了提供抑制抗凝血剂和减缓纤维蛋白凝块降解的方法和装置。 还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。
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公开(公告)号：US06989022B2
公开(公告)日：2006-01-24
申请号：US10291278
申请日：2002-11-08
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
IPC分类号： A61B17/04
CPC分类号： A61L24/0005 , A61B17/00491 , A61B17/0057 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065 , A61M25/0662 , A61M2025/0681
摘要： Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
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8.发明授权Clotting cascade initiating apparatus and methods of use and methods of closing wounds 有权凝血级联引发装置和使用方法以及关闭伤口的方法公开(公告)号：US06478808B2
公开(公告)日：2002-11-12
申请号：US09732423
申请日：2000-12-07
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
IPC分类号： A61B1712
CPC分类号： A61L24/0005 , A61B17/00491 , A61B17/0057 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065 , A61M25/0662 , A61M2025/0681
摘要： Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
摘要翻译： 提供了伤口闭合方法和装置，其通过在基本封闭的无菌容器内激活身体外部的血液流体的凝血级联来利用血液流体，然后将血液流体引入伤口部位以完成凝血。 还公开了提供抑制抗凝血剂和减缓纤维蛋白凝块降解方法的方法和装置。 还公开了单独实施本发明或与优选方法组合和/或与其相关联的试剂盒。
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公开(公告)号：US4399849A
公开(公告)日：1983-08-23
申请号：US281604
申请日：1981-07-09
申请人： Karol L. Nowakowski
发明人： Karol L. Nowakowski
CPC分类号： B27G1/00 , B27M1/08 , G07C3/14 , Y10T83/175 , Y10T83/505
摘要： The invention provides a quality control process for lumber-cutting operations. It normally includes the following steps: (1) treating, with a normally invisible indicator, a portion of the lumber to be cut; (2) recording the physical properties of the portion of lumber; (3) commingling the treated, recorded portion with the remainder of the lumber; (4) performing cutting operations on the lumber; (5) imposing conditions on the lumber that will render the indicator visible on the treated portion; and (6) comparing the cut pieces of the treated, recorded portion with the precut record to determine the efficiency of the cutting operations.
摘要翻译： 本发明提供了一种用于木材切割操作的质量控制过程。 通常包括以下步骤：（1）用通常不可见的指示剂处理要切割的木材的一部分; （2）记录木材部分的物理性质; （3）将经处理的记录部分与剩余的木材混合; （4）对木材进行切割操作; （5）对木材施加条件，使指示器在被处理部分上可见; 和（6）将经处理的记录部分的切割块与预切割记录进行比较，以确定切割操作的效率。
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