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16 条记录 (耗时 0.044 秒)

    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds
    1.
    发明授权
    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权
    制备N-取代的1H-吡唑-5-碳酰氯化合物的方法

    公开(公告)号：US08921567B2

    公开(公告)日：2014-12-30

    申请号：US14235556

    申请日：2012-08-10

    申请人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    发明人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

    摘要翻译： 本发明涉及制备式（I）的N-取代的1H-吡唑-5-碳酰氯化合物的方法，其中R1是氢，卤素，氰基，C1-C6-烷基，C1-C6-氟烷基，C3 C 1-8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 氟烷氧基，C 1 -C 4 - 氟烷氧基-C 1 -C 4烷基，苯基和 喜欢; 每个R 2独立地选自卤素，C 1 -C 6 - 烷基，C 1 -C 6 - 氟代烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 氟代环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 氟烯基，C 1 -C 6烷氧基， 苯基等; r为0,1,2,3或4; 包括以下步骤：i）将其中变量R1，R2和r各自如上定义的式（II）化合物与选自具有碳或氮键合的锂的锂基或与镁结合的碱的碱 具有碳结合镁的无机碱; 和ii）通过使步骤（i）中获得的产物与选自光气或光气当量的试剂反应来进行氯羰化反应，得到式（I）化合物。

    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds
    2.
    发明申请
    Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds 有权

    公开(公告)号：US20140163234A1

    公开(公告)日：2014-06-12

    申请号：US14235556

    申请日：2012-08-10

    申请人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    发明人： Karsten Körber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch ,  Markus Kordes

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carbonylchloride compound of the formula (I) in which R1 is hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, C1-C4-fluoroalkoxy-C1-C4-alkyl, phenyl and the like; each R2 is independently selected from halogen, C1-C6-alkyl, C1-C6-fluoroalkyl, C3-C8-cycloalkyl, C3-C8-fluorocycloalkyl, C2-C6-alkenyl, C2-C6-fluoroalkenyl, C1-C6-alkoxy, phenyl and the like; r is 0, 1, 2, 3 or 4; comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined above, with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

    N-thio-anthranilamide compounds and their use as pesticides
    8.
    发明授权
    N-thio-anthranilamide compounds and their use as pesticides 有权
    N-硫代邻氨基苯甲酰胺化合物及其作为农药的用途

    公开(公告)号：US09044016B2

    公开(公告)日：2015-06-02

    申请号：US14235528

    申请日：2012-08-10

    申请人： Florian Kaiser ,  Karsten Körber ,  Prashant Deshmukh ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

    发明人： Florian Kaiser ,  Karsten Körber ,  Prashant Deshmukh ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

    IPC分类号： A01N43/56 ,  C07D401/04 ,  C07D409/14

    CPC分类号： A01N43/56 ,  C07D401/04 ,  C07D409/14

    摘要： The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R1 is halogen or halomethyl; R2 is hydrogen, halogen or cyano; R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C2-C6-alkenyl or the like; R4 is halogen; R5 and R6 independently of each other are optionally substituted C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl, or together represent an (hetero)aliphatic chain, or the like; k is 0 or 1. The present invention further relates to a method for combating or controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites, to a process for the preparation of a composition for treating infested or infected animals and/or for protecting animals against infestation or infection by parasites, and to a compound according to the invention for use as a medicament.

    摘要翻译： 本发明涉及式（I）的N-硫代 - 邻氨基苯甲酰胺化合物，其立体异构体，盐，互变异构体和N-氧化物，其中R 1是卤素或卤代甲基; R2是氢，卤素或氰基; R3是氢，C1-C4烷基，C1-C4卤代烷基，C2-C6-烯基等; R4是卤素; R 5和R 6彼此独立地是任选取代的C 1 -C 6 - 烷基，C 3 -C 6 - 环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，苯基或一起表示（杂）脂族链等; k是0或1.本发明还涉及一种防治无脊椎害虫的方法，一种保护植物繁殖材料和/或从其生长的植物的方法，包括至少一种根据本发明的化合物的植物繁殖材料 本发明涉及一种治疗或保护动物免受寄生虫感染或感染的方法，涉及制备用于治疗感染或感染的动物的组合物和/或保护动物免受寄生虫感染或感染的方法，以及 根据本发明的化合物用作药物。

    Pyrazole Compounds for Controlling Invertebrate Pests
    9.
    发明申请
    Pyrazole Compounds for Controlling Invertebrate Pests 有权
    用于控制无脊椎动物害虫的吡唑化合物

    公开(公告)号：US20110269770A1

    公开(公告)日：2011-11-03

    申请号：US13120052

    申请日：2009-09-23

    申请人： Steffen Gross ,  Karsten Körber ,  Wolfgang von Deyn ,  Florian Kaiser ,  Prashant Deshmukh ,  Joachim Dickhaut ,  Ronan Le Vezouet ,  Sebastian Sörgel ,  Matthias Pohlman ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi ,  Faraneh Oloumi

    发明人： Steffen Gross ,  Karsten Körber ,  Wolfgang von Deyn ,  Florian Kaiser ,  Prashant Deshmukh ,  Joachim Dickhaut ,  Ronan Le Vezouet ,  Sebastian Sörgel ,  Matthias Pohlman ,  Douglas D. Anspaugh ,  Deborah L. Culbertson ,  Hassan Oloumi-Sadeghi ,  Faraneh Oloumi

    IPC分类号： A01N43/58 ,  A01P7/04 ,  A61P33/00 ,  A01P7/00 ,  C07D403/12 ,  A61K31/501

    CPC分类号： A01N43/58 ,  A01N43/56 ,  A01N43/60 ,  A01N43/647 ,  A01N43/653 ,  A01N43/82 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to pyrazole compounds of formulae I or II and the salts and N-oxides thereof, wherein A is a pyrazole radical of formulae A1, A2 or A3, wherein # denotes the binding site; R41, R42, R43, R51 are H, halogen, CN, NO2, C1-C10-alkyl and the like; R52, R53 are H, halogen, CN, NO2, C1-C10-alkyl, and the like; R61, R62, R63 are H, CN, NO2, C1-C10-alkyl, and the like; T is C(Rt) or N; U is C(Ru) or N; V is C(Rv) or N; W is C(Rw) or N; with the proviso that at least one of the groups T, U, V and W is N; Rt, Ru, Rv, Rw are H, halogen, C1-C4-alkyl and the like; X1 is S, O or NR1a, wherein R1a is selected H, C1-C10-alkyl and the like; X2 is OR2a, NR2bR2c, S(O)mR2d, wherein m is 0, 1 or 2, R2a is C1-C4-alkyl, C1-C4-haloalkyl and the like, R2b, R2c are H, C1-C4-alkyl, C1-C4-haloalkyl and the like, or R2b and R2c together with the nitrogen atom to which they are bound form a heterocycle, and R2d is C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl and the like; and R1 is H, CN, C1-C10-alkyl and the like.The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

    摘要翻译： 本发明涉及式I或II的吡唑化合物及其盐和N-氧化物，其中A是式A1，A2和A3的吡唑基，其中＃表示结合位点; R 41，R 42，R 43，R 51为H，卤素，CN，NO 2，C 1 -C 10 - 烷基等; R 52，R 53为H，卤素，CN，NO 2，C 1 -C 10 - 烷基等; R61，R62，R63是H，CN，NO2，C1-C10-烷基等; T为C（Rt）或N; U是C（Ru）或N; V是C（Rv）或N; W是C（Rw）或N; 条件是组T，U，V和W中的至少一个为N; R 1，R u，R v，R w为H，卤素，C 1 -C 4 - 烷基等; X1是S，O或NR1a，其中R1a选自H，C1-C10-烷基等; X2是OR2a，NR2bR2c，S（O）mR2d，其中m是0,1或2，R2a是C1-C4-烷基，C1-C4-卤代烷基等，R2b，R2c是H，C1-C4-烷基， C1-C4卤代烷基等，或R2b和R2c与它们所结合的氮原子一起形成杂环，R2d是C1-C4-烷基，C1-C4卤代烷基，C3-C6-环烷基等 ; R1为H，CN，C1-C10-烷基等。 本发明还涉及一种控制无脊椎害虫的方法，一种用于保护植物繁殖材料和/或从其生长的植物的方法，包括至少一种根据本发明的化合物的植物繁殖材料的方法， 治疗或保护动物免受寄生虫侵袭或感染，以及含有至少一种本发明化合物的农药组合物。

    N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES
    10.
    发明申请
    N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES 审中-公开
    N-THIO-ANTHRANILAMIDE化合物及其作为杀虫剂的用途

    公开(公告)号：US20140179519A1

    公开(公告)日：2014-06-26

    申请号：US14236351

    申请日：2012-08-10

    申请人： Florian Kaiser ,  Karsten Körber ,  Prashant Deshmukh ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

    发明人： Florian Kaiser ,  Karsten Körber ,  Prashant Deshmukh ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

    IPC分类号： A01N43/56

    CPC分类号： A01N43/56 ,  C07D401/04

    摘要： The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R1 is halogen, methyl or halomethyl, R2 is hydrogen, halogen or cyano; R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C2-C6-alkenyl or the like; R4 is halogen; R5 and R6 independently of each other are optionally substituted C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl, or together represent an (hetero)aliphatic chain, or the like; and k is 0 or 1.The present invention further relates to a method for combating or controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites, to a process for the preparation of a composition for treating infested or infected animals and/or for protecting animals against infestation or infection by parasites, and to a compound according to the invention for use as a medicament.

    摘要翻译： 本发明涉及式（I）的N-硫代 - 邻氨基苯甲酰胺化合物，其立体异构体，盐，互变异构体和N-氧化物，其中R 1是卤素，甲基或卤代甲基，R 2是氢，卤素或氰基; R3是氢，C1-C4烷基，C1-C4卤代烷基，C2-C6-烯基等; R4是卤素; R 5和R 6彼此独立地是任选取代的C 1 -C 6 - 烷基，C 3 -C 6 - 环烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，苯基或一起表示（杂）脂族链等; 本发明还涉及一种防治无脊椎害虫的方法，一种保护植物繁殖材料和/或从其生长的植物的方法，包括至少一种根据本发明的化合物的植物繁殖材料 本发明涉及用于治疗或保护动物免受寄生虫感染或感染的方法，涉及制备用于治疗感染或感染的动物和/或用于保护动物免受寄生虫感染或感染的组合物的方法，以及 用作药物的根据本发明的化合物。