摘要:
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds are beta three adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.
摘要:
Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH.sub.2).sub.n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R.sup.9)R.sup.9' or --CO.sub.2 R.sup.7 ; R.sup.1 is lower alkyl, aryl or arylalkyl; R.sup.2 is hydrogen, hydroxy, alkoxy, --CH.sub.2 OH, cyano, --C(O)OR.sup.7, --CO.sub.2 H, --CONH.sub.2, tetrazole, --CH.sub.2 NH.sub.2 or halogen; ##STR2## R.sup.3 is hydrogen, alkyl, heterocycle or R.sup.4 is hydrogen, alkyl or B; R.sup.5, R.sup.5', R.sup.8, R.sup.8' or R.sup.8" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH.sub.2).sub.n NR.sup.6 COR.sup.7, --CON(R.sup.6)R.sup.6', --CON(R.sup.6)OR.sup.6', --CO.sub.2 R.sup.6, --SR.sup.7, --SOR.sup.7, --SO.sub.2 R.sup.7, --N(R.sup.6)SO.sub.2 R.sup.1, --N(R.sup.6)R.sup.6', --NR.sup.6 COR.sup.7, --OCH.sub.2 CON(R.sup.6)R.sup.6', --OCH.sub.2 CO.sub.2 R.sup.7 or aryl; orR.sup.5 and R.sup.5' or R.sup.8 and R.sup.8' may together with the carbon atoms to which they are attached form an aryl or heterocycle; R.sup.6 and R.sup.6' are independently hydrogen or lower alkyl; and R.sup.7 is lower alkyl; R.sup.9 is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R.sup.9 and R.sup.9' may together with the nitrogen atom to which they are attached form a heterocycle; with the proviso that when A is a bond or --(CH.sub.2).sub.n and R.sup.3 is hydrogen or unsubstituted alkyl, then R.sup.4 is B or substituted alkyl. These compounds are beta.sub.3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.
摘要:
Antihypercholesterolemic activity is exhibited by compounds of the formula ##STR1## wherein: X is hydrogen, alkali metal or ammonium;Y is hydrogen, alkyl, cycloalkyl, aryl, or aralkyl; ##STR2## R is hydrogen, alkyl, ammonium, alkylammonium, or alkali metal (such as Na, Li, or K); andn is 1 or 2.
摘要:
A herbicidal compound which is a Q-substituted 1-phenyl-4,5-dihydro-1,2,4-triazol-5(1H)-one in which the Q-substituent is bonded to the ring-carbon atom at the 5-position of the phenyl group and in which:Q is --CH(R.sup.2)C(R.sup.3) (R.sup.4)Q' or --CH.dbd.C(R.sup.4)Q';R.sup.2 and R.sup.3 are each, independently, H or halogen;R.sup.4 is H or lower alkyl;Q' is COOH, COOZ, COOR.sup.5, CON(R.sup.6) (R.sup.7), CN, CHO or C(O)R.sup.5 ;Z is a salt-forming group;R.sup.5 is alkyl, alkoxycarbonylalkyl, cycloalkyl or aralkyl;each of R.sup.6 and R.sup.7 is, independently, a radical which is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, phenyl, benzyl or SO.sub.2 R.sup.6 or is one of said radicals substituted by halogen, alkyl or cyano; said compound being one whose 5-Methoxy Analogs and 5-Propargyloxy Analog are herbicides.
摘要翻译:作为Q取代的1-苯基-4,5-二氢-1,2,4-三唑-5(1H) - 酮的除草化合物,其中Q取代基在5位上与环碳原子连接 - 其中:Q是-CH(R2)C(R3)(R4)Q'或-CH = C(R4)Q'; R2和R3各自独立地为H或卤素; R4是H或低级烷基; Q'是COOH,COOZ,COOR5,CON(R6)(R7),CN,CHO或C(O)R5; Z是成盐基团; R5是烷基,烷氧基羰基烷基,环烷基或芳烷基; R 6和R 7各自独立地为烷基,环烷基,烯基,炔基,烷氧基,苯基,苄基或SO 2 R 6基团,或者是被卤素,烷基或氰基取代的所述基团之一; 所述化合物是其5-甲氧基类似物和5-炔丙基氧基类似物是除草剂的化合物。
摘要:
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.
摘要:
This invention relates to compositions comprising 1-aryl-4,5-dihydro-1,2,4-triazol-5(1H)-ones (triazolinones) in combination with the herbicide (2,4-dichlorophenoxy)acetic acid (2,4-D), or like substituted phenoxyalkanoic acids, or esters, or alkali metal or ammonium salts thereof; or with certain herbicidal sulfonylureas, or mixtures of these classes of compounds, to provide herbicidal compositions which are highly effective against a broad array of crop weeds, particularly broadleaf weeds, in crops such as wheat.
摘要:
A herbicidal compound of the formula ##STR1## in which Q is --CR.sup.1 (R.sup.2)C(R.sup.3)(R.sub.4)Q' or --CR.sup.1 .dbd.C(R.sup.4)Q';R.sup.1, R.sup.2 and R.sup.3 are each, independently, hydrogen, halogen, or lower alkyl;R.sup.4 is hydrogen or lower alkyl;Q' is COOH, COOZ, COOR.sup.5, CON (R.sup.6)(R.sup.7), CN, CHO or C(O)R.sup.5 ;Z is a salt-forming cation;R.sup.5 is alkyl, cycloalkyl or aralkyl;each of R.sup.6 and R.sup.7 is, independently, hydrogen alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, phenyl, benzyl, or SO.sub.2 R.sup.8 or is one of said radicals substituted by halogen, alkyl, or cyano, R.sup.8 being the same as R.sup.6 other than hydrogen or SO.sub.2 R.sup.8 ;NHet is a monovalent nitrogen-containing organic group; andNHet, X and Y are such that the Methoxy Analog or Propargyloxy Analog of said compound is a herbicide.
摘要:
A herbicidal compound which is a Q-substituted 1-phenyl-4-substituted-1,4-dihydro-5H-tetrazol-5-one in which the Q-substituent is bonded to the ring-carbon atom at the 5-position of the phenyl group and in which:Q is --CH(R.sup.2)C(R.sup.3) (R.sup.4)Q' or --C(R.sup.2).dbd.C(R.sup.4)Q';R.sup.2 and R.sup.3 are each, independently, hydrogen, alkyl, or halogen;R.sup.4 is hydrogen or lower alkyl;Q' is COOH, COOZ, COOR.sup.5, CON(R.sup.6) (R.sup.7), CN, CHO or C(O)R.sup.5 ;Z is a salt-forming cation;R.sup.5 is alkyl, cycloalkyl or aralkyl;each of R.sup.6 and R.sup.7 is, independently, hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, phenyl, benzyl or SO.sub.2 R.sup.8, or is one of said radicals substituted by halogen, alkyl or cyano, R.sup.8 being the same as R.sup.6 other than hydrogen or SO.sub.2 R.sup.8 ; said compound being one whose 5-Methoxy Analog and 5-Propargyloxy Analog are herbicides.
摘要翻译:作为Q取代的1-苯基-4-取代-1,4-二氢-5H-四唑-5-酮的除草化合物,其中Q-取代基与5-位的环碳原子键合 苯基,其中:Q为-CH(R2)C(R3)(R4)Q'或-C(R2)= C(R4)Q'; R2和R3各自独立地为氢,烷基或卤素; R4是氢或低级烷基; Q'是COOH,COOZ,COOR5,CON(R6)(R7),CN,CHO或C(O)R5; Z是成盐阳离子; R5是烷基,环烷基或芳烷基; R 6和R 7各自独立地为氢,烷基,环烷基,烯基,炔基,烷氧基,苯基,苄基或SO 2 R 8,或者是被卤素,烷基或氰基取代的所述基团之一,R 8与除氢 或SO2R8; 所述化合物是其5-甲氧基类似物和5-炔丙氧基类似物是除草剂的化合物。
摘要:
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.
摘要:
Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.