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1.发明申请CHLAMYDIA PNEUMONIAE VACCINE AND METHODS FOR ADMINISTERING SUCH A VACCINE 审中-公开CHLAMYDIA PNEUMONIAE VACCINE AND METHODS FOR ADMINISTERING SUC A VACCINE公开(公告)号：US20080160027A1
公开(公告)日：2008-07-03
申请号：US11950173
申请日：2007-12-04
申请人： Kathryn Frances Sykes , Alexandre Yurievich Borovkov , Bernhard Kaltenboeck , Yihang Li , Chengming Wang
发明人： Kathryn Frances Sykes , Alexandre Yurievich Borovkov , Bernhard Kaltenboeck , Yihang Li , Chengming Wang
IPC分类号： A61K39/02 , C07K16/00 , G01N33/566 , A61P31/00
CPC分类号： G01N33/56927 , A61K39/118 , A61K2039/53
摘要： The present application relates to antigens and nucleic acids encoding such antigens obtainable by screening the Chlamydia pneumoniae genome. In more specific aspects, the present application relates to methods of isolating such antigens and nucleic acids and the methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed by vaccination or antibody preparation techniques.
摘要翻译： 本申请涉及编码可通过筛选肺炎衣原体基因组获得的抗原和核酸。 在更具体的方面，本申请涉及分离这些抗原和核酸的方法以及使用这种分离的抗原产生免疫应答的方法。 抗原产生免疫应答的能力可以通过疫苗接种或抗体制备技术来使用。
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2.发明授权Low antigen-dose immunization utilizing overlapping peptides for maximizing T-helper cell 1 (Th1) immunity against a pathogen 有权低抗原剂量免疫利用重叠的肽，以最大限度地提高针对病原体的T辅助细胞1（Th1）免疫公开(公告)号：US08647636B2
公开(公告)日：2014-02-11
申请号：US13602833
申请日：2012-09-04
IPC分类号： A61K39/40 , A61K39/395 , A61K51/00 , A61M36/14
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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3.发明授权Low antigen-dose immunization for maximizing T-helper cell 1 (Th1) immunity against a pathogen 有权低抗原剂量免疫用于最大限度地提高针对病原体的T辅助细胞1（Th1）免疫公开(公告)号：US09107875B2
公开(公告)日：2015-08-18
申请号：US12949559
申请日：2010-11-18
IPC分类号： A61K35/00 , A61K47/00 , A01N61/00 , C12Q1/68 , A61K39/118 , A61K38/10 , A61K38/20 , A61K38/21 , A61K39/00
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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4.发明申请公开(公告)号：US20120328644A1
公开(公告)日：2012-12-27
申请号：US13602833
申请日：2012-09-04
IPC分类号： A61K39/118 , A61P31/04
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
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5.发明申请Low Antigen-dose Immunization for Maximizing T-helper Cell 1 (Th1) Immunity Against a Pathogen 有权低抗原剂量免疫最大化T辅助细胞1（Th1）对病原体的免疫公开(公告)号：US20120009220A1
公开(公告)日：2012-01-12
申请号：US12949559
申请日：2010-11-18
IPC分类号： A61K39/118 , A61P31/04 , A61P37/04 , A61K39/00 , A61K39/02
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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6.发明申请Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of chlamydia 审中-公开用于疫苗接种的方法和组合物，其包含衣原体的核酸和/或多肽序列公开(公告)号：US20070149474A1
公开(公告)日：2007-06-28
申请号：US11645886
申请日：2006-12-27
CPC分类号： A61K39/118 , A61K2039/53
摘要： The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
摘要翻译： 本发明涉及通过筛选衣原体基因组获得的编码这种抗原的抗原和核酸。 在更具体的方面，本发明涉及分离这些抗原和核酸的方法以及使用这种分离的抗原产生免疫应答的方法。 抗原产生免疫应答的能力可用于疫苗接种或抗体制备技术。
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公开(公告)号：US20060233833A1
公开(公告)日：2006-10-19
申请号：US10515532
申请日：2003-05-23
IPC分类号： A61K39/275 , A61K39/285
CPC分类号： A61K35/76 , A61K38/162 , C12N2710/24232
摘要： The present invention related to use of Parapoxvirus preparations for the treatment of conditions related to infections with strictly intracellular bacteria
摘要翻译： 本发明涉及使用副痘病毒制剂治疗与严格细胞内细菌感染有关的病症
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8.发明授权Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia 失效用于疫苗接种的方法和组合物，其包含衣原体的核酸和/或多肽序列公开(公告)号：US08298542B2
公开(公告)日：2012-10-30
申请号：US12848535
申请日：2010-08-02
IPC分类号： A61K39/00 , A61K39/118 , A61K45/00 , C07H21/02
CPC分类号： A61K39/118 , A61K2039/53
摘要： The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
摘要翻译： 本发明涉及通过筛选衣原体基因组获得的编码这种抗原的抗原和核酸。 在更具体的方面，本发明涉及分离这些抗原和核酸的方法以及使用这种分离的抗原产生免疫应答的方法。 抗原产生免疫应答的能力可用于疫苗接种或抗体制备技术。
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9.发明授权Method and compositions for vaccination comprising nucleic acid and/or polypeptide sequence of chlamydia 失效用于疫苗接种的方法和组合物，其包含衣原体的核酸和/或多肽序列公开(公告)号：US08206724B2
公开(公告)日：2012-06-26
申请号：US11788692
申请日：2007-04-19
IPC分类号： A61K39/118 , A61K39/38 , A61K39/02 , A61K38/00
CPC分类号： A61K39/118
摘要： The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
摘要翻译： 本发明涉及通过筛选衣原体基因组获得的编码这种抗原的抗原和核酸。 在更具体的方面，本发明涉及分离这些抗原和核酸的方法以及使用这种分离的抗原产生免疫应答的方法。 抗原产生免疫应答的能力可用于疫苗接种或抗体制备技术。
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10.发明申请Methods and Compositions for Vaccination Comprising Nucleic Acid and/or Polypeptide Sequences of Chlamydia 失效包括衣原体的核酸和/或多肽序列的疫苗接种的方法和组合物公开(公告)号：US20100316662A1
公开(公告)日：2010-12-16
申请号：US12848535
申请日：2010-08-02
IPC分类号： A61K39/118 , A61P37/04 , A61P31/04
CPC分类号： A61K39/118 , A61K2039/53
摘要： The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of isolating such antigens and nucleic acids and to methods of using such isolated antigens for producing immune responses. The ability of an antigen to produce an immune response may be employed in vaccination or antibody preparation techniques.
摘要翻译： 本发明涉及通过筛选衣原体基因组获得的编码这种抗原的抗原和核酸。 在更具体的方面，本发明涉及分离这些抗原和核酸的方法以及使用这种分离的抗原产生免疫应答的方法。 抗原产生免疫应答的能力可用于疫苗接种或抗体制备技术。
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