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    Process for producing polymethylene polyphenyl polycarbamates
    1.
    发明授权
    Process for producing polymethylene polyphenyl polycarbamates 失效
    聚亚甲基多苯基聚氨酯的制备方法

    公开(公告)号：US4319018A

    公开(公告)日：1982-03-09

    申请号：US164513

    申请日：1980-07-02

    申请人： Katsuharu Miyata ,  Seiji Hasegawa ,  Shinobu Aoki ,  Isao Hara

    发明人： Katsuharu Miyata ,  Seiji Hasegawa ,  Shinobu Aoki ,  Isao Hara

    IPC分类号： C07B61/00 ,  B01J27/00 ,  B01J31/00 ,  B01J31/02 ,  C07C67/00 ,  C07C239/00 ,  C07C269/00 ,  C07D265/16 ,  C08G12/04 ,  C08G12/20 ,  C08G12/26 ,  C08G16/02

    CPC分类号： C07C269/06 ,  Y02P20/582

    摘要： It is disclosed that, in the process for producing polymethylene polyphenyl polycarbamates through the reaction of N-phenyl carbamate with formaldehyde or a formaldehyde-supplying substance in the presence of an acid catalyst, if the reaction is carried out in the concurrent presence of at least one compound or a mixture of at least two compounds selected from the group consisting of N-carboalkoxy (or cycloalkoxy)-2-oxa-4-aza-naphthalenes, bis(N-carboalkoxy(or cycloalkoxy)-anilino)-methanes and N,N'-dicarboalkoxy (or cycloalkoxy)aminobenzyl-anilines, the object product, polymethylene polyphenyl polycarbamate, can be obtained at a high yield. According to the present invention, also a more economical and easily aperable process for producing polymethylene polyphenyl polycarbamate is provided, by the recycling use of the named compound or compounds which have been concurrently present in the reaction system and after the reaction separated and recovered from the reaction product, and also by the recycling use of the aqueous acid solution which has been used as the catalyst, without the interceding removal of organic impurities formed in the reaction but simply with the adjustment of its acid concentration to the predetermined level.

    摘要翻译： 公开了在酸催化剂的存在下，通过氨基甲酸N-苯基酯与甲醛或甲醛供给物质的反应生产聚亚甲基多苯基聚氨基甲酸酯的方法，如果反应至少同时存在 一种化合物或至少两种选自N-烷氧基（或环烷氧基）-2-氧杂-4-氮杂 - 萘，双（N-烷氧基（或环烷氧基） - 苯胺基） - 甲烷和N ，N'-二羧基烷氧基（或环烷氧基）氨基苄基 - 苯胺，可以高产率得到目的产物聚亚甲基多苯基聚氨基甲酸酯。 根据本发明，通过循环使用已经同时存在于反应体系中的命名化合物和在反应中分离和回收反应后，还提供了生产多亚甲基聚苯基聚氨基甲酸酯的更经济且容易令人不快的方法 反应产物，还可以通过循环使用已经用作催化剂的酸性水溶液，而不用中间除去在反应中形成的有机杂质，而是简单地将其酸浓度调节到预定水平。

    Process for the preparation of indigo compounds
    4.
    发明授权
    Process for the preparation of indigo compounds 失效
    制备靛青化合物的方法

    公开(公告)号：US5187283A

    公开(公告)日：1993-02-16

    申请号：US796265

    申请日：1991-11-21

    申请人： Yoshihiro Yamamoto ,  Usaji Takaki ,  Shinobu Aoki ,  Yoshihisa Inoue ,  Isao Hara

    发明人： Yoshihiro Yamamoto ,  Usaji Takaki ,  Shinobu Aoki ,  Yoshihisa Inoue ,  Isao Hara

    IPC分类号： C09B7/02

    CPC分类号： C09B7/02

    摘要： An indigo compound is prepared from a corresponding indole compound which is unsubstituted at the 2- and 3- positions. The indole compound and an organic hydroperoxide are reacted in the presence of a catalyst which is a metal selected from the group consisting of the metals of Groups 4, 5 and 6 of the periodic table or a compound of the metal. The reaction is conducted while taking out water from a reaction system, said water being that introduced in the reaction system or formed during the reaction, or while controlling the amount of water, which is introduced in the reaction system, at a level not greater than 1 mole per mole of the indole compound.

    Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
    9.
    发明授权
    Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same 有权
    开关荧光纳米粒子探针和荧光颗粒成像方法使用相同

    公开(公告)号：US09370589B2

    公开(公告)日：2016-06-21

    申请号：US13818392

    申请日：2011-08-08

    申请人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

    发明人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

    IPC分类号： A61K9/14 ,  A61K49/00

    CPC分类号： A61K49/0089 ,  A61K49/0032 ,  A61K49/0093 ,  Y10S977/773 ,  Y10S977/927

    摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

    摘要翻译： 本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含： 必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和 荧光染料被封装在单分子组装中。