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公开(公告)号：US4764466A
公开(公告)日：1988-08-16
申请号：US799239
申请日：1985-11-18
CPC分类号： C12N11/00 , A61L2/0011 , A61L2/0094 , C12N9/96
摘要： A fibrinolytic enzyme immobilized on a carrier is stabilized by treating the surface of the carrier on which the enzyme is immobilized with a basic amino acid. The amino acid is preferably histidine, arginine or lysine. Carriers may be inorganic materials, natural polymeric materials or synthetic polymeric materials, in a variety of forms. Fibrinolytic enzymes immobilized include plasmin, brinase, urokinase, streptokinase and tissue plasminogen activator. The stabilized immobilized fibrinolytic enzyme maintains activity better during storage or sterilization.
摘要翻译： 通过用碱性氨基酸处理固定有酶的载体的表面来稳定固定在载体上的纤维蛋白溶解酶。 氨基酸优选为组氨酸，精氨酸或赖氨酸。 载体可以是各种形式的无机材料，天然聚合材料或合成聚合材料。 纤维蛋白溶解酶固定化包括纤溶酶，brinase，尿激酶，链激酶和组织纤溶酶原激活剂。 稳定的固定化纤维蛋白溶解酶在储存或灭菌期间保持活性更好。
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公开(公告)号：US5360415A
公开(公告)日：1994-11-01
申请号：US804362
申请日：1991-12-10
CPC分类号： A61L29/145 , A61L29/085 , A61M25/0017
摘要： An anti-infective catheter on which a layer of a water absorbing polymer is formed. Since the layer of the water absorbing polymer swells by absorbing body fluid in subcutaneous tissue, space between the inserted catheter and its peripheral skin moiety is filled quickly, thus preventing penetration of pathogens in the living body along the wall of the catheter. The anti-infective catheter of the present invention can be inserted in the living body easily without forming a site for the arrangement of a cuff and can prevent penetration of pathogens immediately after its insertion without affecting peripheral tissue.
摘要翻译： 一种抗感染导管，其上形成有吸水聚合物层。 由于吸水性聚合物层通过吸收皮下组织中的体液而膨胀，所以插入的导管与其周边皮肤部分之间的空间被快速填充，从而防止病原体沿导管的壁渗透。 本发明的抗感染导管可以容易地插入生物体中，而不形成用于袖带布置的部位，并且可以防止病原体插入后立即渗透而不影响外周组织。
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